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Showing 1 to 8 of 8 for “"Nerve conduits"”.
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KERATIN BIOMATERIAL SCAFFOLDS FOR PERIPHERAL NERVE REGENERATION
Peripheral nerve injury is a relevant clinical concern. Although surgical management of these injuries has improved over time, the current "gold standard" for nerve transection injury, autograft, has many limitations. Nerve conduits are used as an alternative to autograft surgery but they are …
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Development of antibacterial Polyhydroxyalkanoates for their use in nerve tissue engineering
The fabrication of nerve conduits (NGCs) with the appropriate features for a successful nerve regeneration is not always possible/fulfilled. The currently available implants partially meet the requirements of such medical devices. Despite the evolution of the polymer field and hydrogels, not much …
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Regeneration of Peripheral Nerves Using Neuroinductive Biomaterial Scaffolds
… resulting in a substantial number of peripheral nerve injuries that account for more than $150 billion in health care costs. Clinically, treatment consists of direct surgical repair, implantation of a nerve guidance conduit or the use of an autograft. However, less than 50% of individuals that …
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Mechanical modeling of tissue response during early stage entubulated peripheral nerve regeneration
After severe peripheral nerve injury, such as transection, regeneration has been observed over variable gap lengths with the use of the nerve stump entubulation method. Following entubulation, exudate from transected nerve stumps coagulates into a fibrin matrix within the entubulated space by the …
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Crosslinked Hyaluronic Acid Hydrogel Networks Designed as Mechanical Actuators
… applications, such as wound closure/healing and nerve regeneration, where polymeric actuators have been underutilized. These applications however call for a polymer system that can actuate at controlled slow speeds and sustain this actuation for several days. At present there is a lack of such …
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Fabrication and evaluation of a collagen-based fiber-gel three-dimensional construct for peripheral nerve repair
Nerve regeneration following a peripheral nerve injury often relies on growth cone- mediated guidance and the presence of Schwann cells to support the regenerating axons and remyelinate portions of denervated nerve pathways. The emphasis of this work is to develop a synthetic nervous tissue …
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Novel Polyhydroxyalkanoate blends: their characterisation and possible applications
… of application including the preparation of nerve conduits. The water contact angle value for neat P(3HB) film was 70.37o and for P(3HO) was 99.94o. In the case of blend films P(3HO)/P(3HB) (5:1) and P(3HB)/P(3HO)(5:1), the θH2O was 90.39o and 80.0o respectively. The water contact angle …