Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"Nerve Tissue Proteins"”.
-
Role of Neuroligin in Synapse Formation and Autism
Neuroligins mediate synaptogenesis through formation of a trans-synaptic complex with presynaptic neurexins. Interaction of neuroligin 1 with neurexins is regulated by alternative splicing of both neuroligin 1 (at splice site B) and of neurexins (at splice site #4). Full-length neuroligin 1 that …
-
Structural and Functional Studies of the Munc13 MUN Domain and the RIM C2B Domain
… through exocytosis of synaptic vesicles. Many proteins are involved the regulation of neurotransmission. The central fusion machinery includes the SNARE proteins and Munc18- 1. Besides these universal components, many other neuronal specific proteins are also involved in regulating …
-
Structural and Functional Studies of Munc18 and SNARE Proteins
… Essential components of this machinery are proteins from the Sec1/Munc18 (SM) and SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptors) families. SNAREs function by forming a four-helix bundle called SNARE complex; assembly of the SNARE complex brings two membranes …
-
Neuronal PAS Domain 1 Protein and Its Hypothetical Relationship to Autism
… PAS-A and PAS-B domains, the NPAS1 and NPAS3 proteins appear to be endowed with diametrically opposing functional properties. Interestingly, a translocation that disrupts the NPAS3 gene has been reported in a family suffering from schizophrenia. NPAS3-deficient mice have been reported to have …
-
Structural and Functional Studies of C2-Domain Proteins Involved In Neurotransmitter Release
… by synaptic vesicle exocytosis at presynaptic nerve terminals. This process is extremely fast and strictly regulated by the intracellular Ca2+ concentration. To achieve this exquisite regulation, many proteins are involved. The central fusion machinery includes the SNARE proteins synaptobrevin, …
-
Using Chemically Modified Oligonucleotides to Modulate Gene Expression, Treat Genetic Diseases, and Probe Novel Mechanisms of RNA Interference
A number of inherited neurological disorders remain incurable despite having well-defined monogenic etiologies. One example is Huntington's disease (HD), which is caused by CAG trinucleotide expansion in the gene HUNTINGTIN (HTT) and production of toxic glutamine-expanded protein. Targeting HTT …
-
Mechanistic Insights into the Role of Munc13 in Synaptic Vesicle Docking, Priming, and Fusion
Neurotransmitter release is a fundamental aspect of neuronal communication that relies on the fusion of synaptic vesicles with the presynaptic membrane. These fusion events are tightly regulated by the influx of Ca2+, which is sensed by the complex protein machinery at the axon terminal. In order …
-
Sensory Neurogenesis and the Role of PRDM12 in Nociceptor Development and Function
Nociceptors are a set of peripheral neurons responsible for the detection of noxious stimuli. They function to alert us to the presence of potentially damaging internal and environmental threats, thereby playing an important role in allowing us to react and avoid danger. Unfortunately, for over 30% …
-
Understanding Autism Pathology: Insights from Genetic Mouse Model Manipulation of KCTD13 and SHANK3
Copy number variations (CNVs) contribute to the etiology of Autism Spectrum Disorders (ASDs). Deletions/duplications in human chromosomal region 16p11.2 are frequently associated with ASD and other neurodevelopmental disorders. Specific genes within this region may be important for determining …
-
Insights into the Functions of Munc18-1 in Neurotransmitter Release
… triggered by Ca2+. Several conserved proteins are involved in regulating the entire process. The central membrane fusion machinery in neurons includes Munc18-1 and the SNARE proteins syntaxin-1, SNAP-25 and synaptobrevin. The SNAREs form tight SNARE complexes that bring the vesicle …
-
Novel Roles for the Activity-Regulated Genes Arc and Npas4 in Stress- and Cocaine-Induced Plasticity
… and characterized. Here, we focus on two key proteins that participate in activity-dependent synaptic plasticity, the neuronal Per Arnt Sim Domain protein 4 (NPAS4) and the activity-regulated cytoskeleton-associated protein (Arc). We utilize a series of ethologically relevant behavioral …
-
Dissecting the Function of FARP1 and Rho GTPases in Semaphorin-Plexin Signaling: Structural Perspective
The Semaphorin-Plexin signaling is important for regulating axon guidance. Binding of Semaphorin to the Plexin receptor induces the dimerization of Plexin and stimulates its cytoplasmic GAP activity towards Rap, resulting in cytoskeleton re-organization. The growth cone of an axon then turns …
-
Unraveling the Functions of Synaptotagmin and Munc13 in Neurotransmitter Release
… crucial to investigate functions of individual proteins to understand the mechanism of membrane fusion and neurotransmitter release. Therefore, we investigated the mechanism of membrane bridging by synaptotagmin. Our cryo-electron microscopy (cryo-EM) images showed that a majority of …
-
Molecular Basis of Coupling Calcium Sensing to Fast Membrane Fusion by Synaptotagmin-1 in Neurotransmitter Release
The content of this work is based on the previously published articles that are cited below.
-
Ceramide-Induced Alternative Translocation of TM4SF20
The polytopic membrane protein TM4SF20 (transmembrane 4 L6 family 20) is a protein containing four transmembrane helices that inhibits the Regulated Intramembrane Proteolysis (RIP) of the transcriptional factor CREB3L1 (cAMP response element binding protein 3-like 1), a transcription factor …
-
ApoE Receptors in Alzheimer's and CNS Function
… the mechanisms by which lipid transport proteins cause central nervous system (CNS) disease are not completely understood. Here, the ApoE receptor family and its ligands and their roles in CNS function and neurological disease were explored. It has been previously shown that ApoE4 renders …
-
Identification of a Novel ERK 1/2-Interacting A-Kinase Anchoring Protein
… orthologs for this and other radial spoke proteins, however, remain to be identified and fully characterized. Mammalian RSP3 was found to interact with ERK2 through a yeast two-hybrid screen designed to identify interactors that have a higher affinity for the phosphorylated, active form of …
-
Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming
The activity of pro-neural signaling molecules and transcription factors is sufficient to induce the transdifferentiation of lineage-restricted fibroblasts into functional neurons; however, a mechanistic model of the immediate-early events that catalyze this conversion has not been well defined. We …
-
Dissecting Roles for the Macromolecular Machinery Involved in Neurotransmitter Release
… of interactions between numerous accessory proteins and the trans-SNARE for proper regulation of SNARE complex formation, and therefore fusion.
-
ADAP1 Promotes Latent HIV-1 Reactivation by Tuning the KRAS-ERK-AP-1 Signaling-Transcriptional Axis
Immune stimulation fuels cell signaling-transcriptional programs that induce biological responses to eliminate virus-infected cells. Yet, retroviruses that integrate into host cell chromatin, such as HIV-1, co-opt these programs to switch between latent and reactivated states. However, many …