Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"Nerve Regeneration"”.
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Cellular Interactions During Motor Nerve Regeneration
Vertebrate peripheral nerves can regenerate, enabling severed axons to reconnect with their original synaptic targets. The interactions between injured nerves with cells in their environment, as well as the functional significance of these interactions, have not been determined in vivo and in real …
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Spinal cord implants for nerve regeneration
… the last couple decades that the potential for regeneration in the spinal cord became accepted. However, there is still no proven method for enabling this regeneration. An implant model was developed to help aid in repair, recovery, and regeneration in the spinal cord following spinal cord …
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KERATIN BIOMATERIAL SCAFFOLDS FOR PERIPHERAL NERVE REGENERATION
Peripheral nerve injury is a relevant clinical concern. Although surgical management of these injuries has improved over time, the current "gold standard" for nerve transection injury, autograft, has many limitations. Nerve conduits are used as an alternative to autograft surgery but they are …
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Regulation of peripheral nerve regeneration by the mTOR pathway
… their axons following injury. Successful regeneration depends upon both extrinsic cues in the environment and the activation of intrinsic mechanisms to promote regrowth. A number of inhibitory molecules in the CNS environment that prevent axonal regrowth have been identified, but less is …
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Large-scale transgenesis and nerve regeneration in C. elegans
… and chemical compounds that enhance neuronal regeneration can lead to development of therapeutics to combat nervous system injuries and neurodegenerative diseases. By combining high-throughput microfluidics and femtosecond laser microsurgery, we demonstrate for the first time large-scale in …
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Nerve regeneration induced by collagen-GAG matrix in collagen
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Ocean Engineering, 1994.
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Deposition of Electroactive Polymers onto Polymer Nanofibers for Nerve Regeneration
Although peripheral nerves can regenerate after an injury through the Wallerian degeneration process, the degree of regeneration is often not efficient enough to achieve full return of functionality. To overcome the disadvantages of current nerve repair approaches, peripheral nerve tissue …
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The Role of Slit/Robo Signalling in Peripheral Nerve Regeneration
The role of Slit/Robo signalling in peripheral nerve regeneration. Slit/Robo chemorepulsive signalling has been shown to play a role in axon pathfinding during the development of the central nervous system. There is evidence that Slit/Robo are expressed in the adult intact and injured peripheral …
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Novel signalling pathways resolving the inflammatory response during peripheral nerve regeneration
… to be tightly regulated to ensure efficient regeneration and to prevent chronic inflammation. Currently there is limited knowledge regarding which signalling pathways act to control both the inflammatory response and macrophage efflux that allows tissue homeostasis to resume within the …
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Influence of implant parameters on the mechanisms of peripheral nerve regeneration
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1998.
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Imaging studies of peripheral nerve regeneration induced by porous collagen biomaterials
… urgent need to develop treatments for inducing regeneration in injured organs. Porous collagen-based scaffolds have been utilized clinically to induce regeneration in skin and peripheral nerves, however still there is no complete explanation about the underlying mechanism. This thesis utilizes …
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Peripheral nerve regeneration through collagen devices with different in vivo degradation characteristics
… people are treated each year for peripheral nerve injuries that require surgery. Functional recovery of motor and sensory capability is limited following autograft, the most common procedure for peripheral nerve repair. Tubulation repair of a transected peripheral nerve presents an …
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Mechanical modeling of tissue response during early stage entubulated peripheral nerve regeneration
After severe peripheral nerve injury, such as transection, regeneration has been observed over variable gap lengths with the use of the nerve stump entubulation method. Following entubulation, exudate from transected nerve stumps coagulates into a fibrin matrix within the entubulated space by the …
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A freeze-drying process for fabrication of polymeric bridges for peripheral nerve regeneration
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1988.
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Peripheral nerve regeneration through tubular devices : a comparison of assays of device effectiveness
Peripheral nerve injury affects nearly 200,000 patients annually in the United States and unless treated results in paralysis of skeletal muscle and loss of sensation. Previous studies in this laboratory have focused on comparing the effectiveness of various tubular devices in repairing …
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Investigation of Keratin and Keratin-Containing Composite Biomaterials: Applications in Peripheral Nerve Regeneration
… vitro and in vivo settings for different tissue regeneration applications. Over three decades, keratin extraction technology has been continuously modified, and these differences in extraction processes have distinct effects on the characteristics of the end product. In this work, we examine the …
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Canine mandibular osteotomy model: the effects of fixation on bone healing and nerve regeneration
… 16 weeks postoperatively. The inferior alveolar nerves were evaluated electrophysiologically pre-operatively and at 4, 8, and 16 weeks postoperatively. Nerves were histologically evaluated at 4, 8, and 16 weeks after injury. Nerve function disappeared immediately postoperatively and returned in …
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Molecular biology of peripheral nerve regeneration: Expression and role of Netrin-1, DCC and Runx2
Damage to the peripheral nerves causes a series of molecular, cellular, and structural changes critical to initiating a successful regenerative process involving degeneration, inflammation, axon re-growth and innervation of the denervated target, and finally functional recovery. In this thesis I …
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