Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Nerve Growth Factor (NGF)"”.
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Chronic Olanzapine Treatment Eliminates Cognitive Deficits Produced by Neonatal Quinpirole Treatment.
… a significant decrease in the neurotrophins nerve growth factor (NGF) in the hippocampus and brain-derived neurotrophic factor (BDNF) in the frontal cortex. Olanzapine treatment alleviated the decrease in NGF. The results suggest that olanzapine eliminates cognitive impairment and may have …
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Type I PIP5Kα negatively regulates NGF-induced neurite outgrowth in PC12 cells
… an isoform of PIP5Kα, plays a role in neurite outgrowth. For this, I generated a stable PC12 cell line lacking PIP5KIa by microRNA (miRNA) expression, leading to decreased PtdIns(4,5)P2 level. Results show that neurite outgrowth induced by nerve growth factor (NGF) was more prominent in …
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Effects of tumor necrosis factor alpha on nitric oxide synthase in nerve growth factor-responding cells
… (AD) patients accompanied by a decrease in nerve growth factor (NGF)-responsive cholinergic neurons. I report a synergistic effect of the cytokine tumor necrosis factor alpha (TNFa) and NGF on expression of nitric oxide synthase (NOS), in rat pheochromocytoma PC12 cells. NGF/TNFa-promoted …
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The morphology, neurochemistry, and consequences of sympathosensory plexuses
… depend on the function of neurotrophins such as nerve growth factor (NGF). One population of neurons that rely heavily on NGF for axonal growth and survival is the postganglionic sympathetic neurons. Trauma or disease resulting in injury to the peripheral nervous system causes an increase in the …
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COMBINATORIAL DEVELOPMENT OF NANOSTRUCTURED MATERIAL LIBRARIES FOR THE STUDY OF CELL SUBSTRATE INTERACTION
… on five different morphologies in presence of nerve growth factor (NGF) and the results suggest that the increasing roughness not only diminishes cellular attachment but also reduces the probability of differentiation and formation of focal adhesions. The second phase of the work targets the …
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NADPH oxidase in PC12 cell differentiation and apoptosis
… human development and regenerative medicine. One factor linked to differentiation of neurons <em>in vivo</em> as well as <em>in vitro</em> is the generation of reactive oxygen species (ROS). In addition, neurodegeneration is the disease of the old age that is currently affecting millions. Although …
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Regulation of n-3 PUFA biosynthesis in proliferating and differentiated PC12 pheochromocytoma cells
… acid (PUFA) biosynthesis in proliferating and NGF-differentiated PC12 pheochromocytoma cells deficient in n-3 docosahexaenoic acid (DHA, 22:6n- 3) was studied. A dose- and time dependent increase in eicosapentaenoic acid (EPA, 20:5n-3), docosapentaenoic acid (DPA, 22:5n-3) and DHA in …
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Refining Our Understanding of the Hematopoietic Stem Cell Niche
… is that HSCs, periarteriolar stromal cells, and nerve fibers are closely associated in rare periateriolar niches. Using a novel marker to identify HSCs in three-dimensional confocal images, -catulin-GFP, we measured the distances from thousands of HSCs to various landmarks in the bone marrow. We …
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Determining the Role of Trib3 in Neuronal Apoptosis
… for a limited supply of target-derived growth factor. A classic example includes neurons of the superior cervical ganglia that compete for nerve growth factor (NGF). Cell death arising from lack of NGF stimulation is a topic of intense research and remains enigmatic. Pro-apoptotic …
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Effects of oxidative stress and neuroprotection in apoptosis in neuronal cell models
… sensitivity to toxicity. The neurotrophic factor, nerve growth factor (NGF) was shown to cause protection against OS. Cells pre-treated with NGF showed higher viability after OS, generally less apoptotic morphology, recorded less apoptotic nucleiods, generally lower levels of intracellular …
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The effects of anticholinesterases and β-amyloid pathology on neurotrophin signaling in the mouse brain
… of synaptic connections with neurotrophic factors, such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). The first aim of this study was to examine the effects of cholinesterase inhibitors (ChEi), the first-line drugs for AD, on Trk neurotrophin receptor activity …
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Growth Factor Delivery From Fibrin Matrics Containing Affinity-Based Delivery Systems To Treat Peripheral Nerve Injury
… to serve as a potential treatment for peripheral nerve injury. The use of an affinity-based delivery system: ABDS) with growth factors in a nerve guidance conduit: NGC) was hypothesized to promote nerve regeneration and functional recovery following a critical nerve defect. Evaluation of …
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Calcium signalling in the nervous system
… those belonging to the central and peripheral nerve system. Free intracellular Ca2+ ([Ca2+]i) in resting cells is maintained at low concentrations (submicromolar range). In contrast, the Ca2+ concentration in the extracellular space and the endoplasmic lumen exceeds the 103 - 106 range. This …
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Evaluation of inhibitors of histone deacetylases as potential neurotrophic agents
… were tested alone and in combination with nerve growth factor (NGF). An in vitro method has been standardized that measures neurite outgrowth along with cytotoxicity of test compounds in a single assay. The neurotrophin signaling pathways were interrogated with selective inhibitors of …
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Mechanisms Underlying Mesenchymal Stem Cell-Derived Extracellular Vesicle Modulation of Sensory Neuron Excitability
… of dorsal root ganglion (DRG) neurons induced by nerve growth factor (NGF), a key mediator implicated in OA pathogenesis and associated pain. The present study sought to elucidate the mechanisms by which MSC-EVs prevent NGF-induced sensitisation of DRG neurons, using whole-cell patch-clamp …
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Early Effects of Organophosphate Compounds on In Vitro Intracellular Signaling and Levels of Active Neurotrophin Receptors, and on In Vivo Neurotrophin Concentrations
… characterized by Wallerian-like degeneration of nerves in the central and peripheral nervous system after exposure to neuropathic OP compounds. There are many questions surrounding the mechanisms of the onset of OPIDN, including possible alterations in proteins associated with neuronal …
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Sources and Targets of Trophic Factors in the Avian Locus Coeruleus and Oculomotor System
… on sources and transport routes of neurotrophic factors in the avian nervous system. How trophic signals are transmitted in the nervous system is a key question in neuroscience research. Cells in the nervous system can retrieve trophic signals by two distinct routes. One is through axonal …
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Voluntary Exercise and Neurotrophin Signaling Affect the Development and Presentation of Painful Neuropathy
… found that glial cell line-derived neurotrophic factor (GDNF) was decreased in the diabetic mice. These results suggest that diabetes does alter neurotrophin levels, which may lead to PDN. Next, using a high-fat diet to induce prediabetes, we found increased levels of nerve growth factor (NGF) …
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Co-Signaling by Neurotrophic Factors and the Extracellular Matrix for Axonal Growth and Neuronal Survival
Neurotrophic factors (NTFs) and the extracellular matrix (ECM) are important regulators of axonal growth and neuronal survival in mammalian nervous system. Understanding of the mechanisms of this regulation is crucial for the development of posttraumatic therapies and drug intervention in the …
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Isoform-Specific Roles of Extracellular Signal-Regulated Kinases in Pain
… due to the inflammatory mediator, nerve growth factor: NGF). Nociceptive sensitization was not reduced in all models tested, since ERK2f/f;NaV1.8-Cre mice developed robust heat hypersensitivity to other inflammatory and chemical insults. Biochemical analysis of both lines revealed …
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