Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Nerve Degeneration"”.
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Stacked generalization for early diagnosis of Alzheimer's disease
… (AD) is a neurological disorder characterized by nerve degeneration and neuronal death. The diagnosis of AD at an early stage is a major concern due to growing number of elderly people affected by the disease, as well as the lack of a standard diagnosis procedure available to community clinics. A …
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Mitochondrial dysfunction in hereditary optic neuropathies
… gene encoding Complex I subunits leads to optic nerve degeneration is still unknown, although is well accepted that other genetic or environmental factors are involved in the modulation of pathology, where a pivotal role is certainly played by oxidative stress. We studied the relationship between …
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Design of three-dimensional axon stretch growth device
Spinal Cord Injury (SCI) causes destruction and degeneration of axons in the white matter of the spinal cord, resulting in functional loss and paralysis. A successful treatment of SCI requires axons to regenerate across damaged regions. Current studies focus on identifying mechanisms to promote …
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Daubechies and quadratic b-spline wavelets for automated early diagnosis of Alzheimer's disease
… is a neurological disorder characterized by nerve degeneration and neuronal death. The diagnosis of Alzheimer's disease at an early stage is a major concern due to the lack of a standard and effective diagnosis procedure available to community healthcare providers, as well as the increasing …
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Characterisation of LITAF, a protein associated with Charcot-Marie-Tooth disease type 1C
… affects the peripheral nervous system leading to nerve degeneration. CMT is categorised into two forms, ‘axonal’ and ‘demyelinating’, which reflects the main site of pathology as the axon or Schwann cells respectively. Over 90 genes have been identified associated with the disease. Among the genes …
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UCHLI in the Mammalian Nervous System
… cord, and lumbar dorsal root ganglia, described degeneration of muscle spindles, and established a timecourse of degeneration of neuromuscular junctions. Presented in this thesis is the culmination of these studies.
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Tumor Necrosis Factor Dependent Mechanisms and Neuroprotective Strategies in Models of Parkinson's Disease
… reduced 6-hydroxydopamine-induced nigral degeneration by 50% and attenuated amphetamine-induced rotational behavior, indicative of striatal dopamine preservation in a rodent model of Parkinson's disease. Similar protective effects were observed with in vivo chronic co-infusion of …
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The Role of TNF Signaling in Regulating Beta-Amyloid Burden in the 3xTgAD Mouse Model of Alzheimer's Disease
… neurotoxicity that directly contribute to neurodegeneration or loss of specific neuronal populations is less clear. The pro-inflammatory cytokine Tumor Necrosis Factor (TNF) has been implicated in AD by its elevated presence in serum and post-mortem brains of patients with AD. To test the …
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Phosphatase Regulation of Mechanical Stress and Aging in C. elegans
… cell tolerance for physical stress results in degeneration and death via unclear mechanisms. In the nematode C. elegans, I developed a model to study cellular degeneration in response to mechanical stress caused by blunt force trauma. I identified a dual-specificity MAPK phosphatase, VHP-1, as …
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Iron Dysregulation and Inflammation in Alzheimer’s Disease
… the early stages of AD and other forms of neurodegeneration, iron dysregulation and inflammation, both of which can promote the increased production of amyloid precursor protein (APP). We have measured different pools of brain iron in transgenic iron regulatory protein 2 knockout (IRP2-/-) mice …