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Showing 1 to 9 of 9 for “"Neprilysin"”.
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Σύγχρονα φάρμακα στην καρδιολογία - το παράδειγμα του αναστολέα της νεπριλυσίνης / Contemporary drugs in cardiology: the case of neprilysin inhibitors
Η καρδιακή ανεπάρκεια είναι μια χρόνια κατάσταση κατά την οποία η καρδιά δεν μπορεί να αντλήσει επαρκές αίμα για να καλύψει τις ανάγκες του οργανισμού. Μπορεί να οφείλεται σε παθήσεις όπως η στεφανιαία νόσος, η υπέρταση ή οι βαλβιδοπάθειες. Τα συχνότερα συμπτώματα είναι δύσπνοια, κόπωση, οιδήματα …
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Sex-Related Differences in Hypertension and Renal Injury: Role of the Renin-Angiotensin System
… strain. Renal Ang II was lower, while cortical neprilysin, an enzyme that degrades Ang II and generates Ang-(1-7) from Ang I, was significantly higher in female versus male mRen(2).Lewis. Neprilysin is stimulated by estrogen and may contribute to lower blood pressure through the renal metabolism …
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STUDIES ON ANGIOTENSIN-(1-7) AND MITOCHONDRIA: THE ROLE OF AN INTRACELLULAR RENIN-ANGIOTENSIN SYSTEM WITHIN THE KIDNEY
… the kidney that include the endopeptidases neprilysin (NEP) and thimet oligopeptidase (TOP) that process Ang I directly to Ang-(1-7).
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Factors Regulating the Intrarenal Renin-Angiotensin System and Renal Damage During Aging
… for renin, while the expression of ACE2 and neprilysin remain the same with a decrease in ACE expression compared to younger animals. There was no change in the gene expression of AT1a, AT1b, AT2 or Mas receptors in the dorsomedial medulla during aging in the F344 rats but there was a …
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Ávísun lyfjameðferða eftir mismunandi svipgerðum hjartabilunar við útskrift á hjartadeild Landspítala: Eru íslenskir hjartabilunarsjúklingar að fá meðferð í samræmi við klínískar leiðbeiningar Evrópsku hjartalæknasamtakanna?
… breytihvatahemlum (ACEI): angíóntensín II/Neprilysin viðtakahemil (ARNI) eða angíótensín II viðtakablokka (ARB). Sami ávinningur er talinn ná til HFmrEF sjúklinga en ekki til HFpEF svipgerðarinnar. Markmið: Rannsaka lyfjaávísanir vegna hjartabilunarinnlagna eftir svipgerðum og greina …
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Comparing Healthcare Resource Utilization and Costs in HFPEF patients using SGLT2-inhibitor Combination Treatments: A Retrospective Claims Analysis
… antagonists (MRAs) or angiotensin receptor-neprilysin inhibitors (ARNIs) as adjunctive therapy. However, real-world evidence comparing healthcare resource utilization (HCRU) and costs between these combination therapies remains limited. Methods: We conducted a retrospective cohort study …
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Monocytes as Gene Therapy Vectors for the Treatment of Alzheimer’s Disease
… with an amyloid degrading enzyme such as neprilysin offers a powerful novel therapeutic tool for the treatment of AD.
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Divergent regulation of zinc metallopeptidases by shear stress in macrovascular endothelial cells via an NADPH oxidase - superoxide pathway
… can modulate vascular endothelial expression of neprilysin (NEP, EC3.4.24.11) and thimet oligopeptidase (TOP, EC3.4.24.15) in an inverse manner, with functional consequences for endothelial homeostasis. Results: Exposure of cultured bovine/human aortic endothelial cells (BAECs/HAECs) to LSS of …
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Regulation of the hif-1-dependent hypoxic stress response by C. elegans
… response. Secondly, we found that loss of the neprilysin metallopeptidase, nep-2, suppressed the egl-9 Egl phenotype through the degradation of multiple neuropeptides including the known NEP-2 target SNET-1. Our findings reveal two different pathways that function downstream of egl-9 to …