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Showing 1 to 20 of 41 for “"Nephrotoxicity"”.
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The renal handling and nephrotoxicity of paraquat
Thesis (M.S.)--Michigan State University. Dept. of Pharmacology, 1975
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Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity
… via active secretion and is associated with nephrotoxicity. Currently, prehydration therapy is employed to prevent toxic renal side effects; however it has not been completely ameliorated. The studies described herein aim to determine the mechanism in which cisplatin enters the kidney cell …
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Nephrotoxicity associated with preeclampsia in an Arginine Vasopressin induced rat pregnancy model
Submitted in fulfillment of the requirements for the degree of Doctor of Philosophy: Health Sciences, Durban University of Technology, Durban, South Africa, 2022.
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Isolation of hog renal brush border membrane vesicles with application to the study of cadmium nephrotoxicity
The epithelial cell of the kidney proximal convoluted tubule, like that of the small intestine, consists of two distinct plasma membrane surfaces referred to as the brush border, or luminal surface, and the basal-lateral, or contraluminal surface. Once isolated, membrane vesicles formed from the …
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Langfristige Entwicklung Zytostatika-induzierter Nierenfunktionsstörungen bei pädiatrisch-onkologischen Patienten
Nephrotoxicity is a frequent complication of chemotherapeutic treatment. The aim of the investigation is to analyse the long-term nephrotoxic sequelar in patients with malignancies. Using optimized sodium dodecyl sulfate polyacrylamid gel electrophoresis (SDS-PAGE) even in proteinuria < 150 mg/day …
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The Role of Megalin in Aminoglycoside-Associated Toxicity in the Kidney
… aminoglycosides and addressing their associated nephrotoxicity. Subsequent studies show that amikacin accumulates in the kidney during the filtration process and triggers a cascade of cellular events resulting in cell death, acute kidney injury and in some cases, chronic kidney failure. …
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Identification of Early Diagnostic and Predictive Biomarkers of Cisplatin-Induced Acute Kidney Injury Using Metabolomics
… several toxic effects to non-cancerous tissues. Nephrotoxicity is the main dose-limiting toxicity in cisplatin therapy, manifesting as acute kidney injury (AKI) in approximately one-third of patients receiving cisplatin. AKI is defined as an abrupt decline in kidney function and is associated …
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Physiologically-Based Kinetics and Mechanistic Models to Assess Exposure to Chemicals
… computational models exist to investigate nephrotoxicity. However, the kidney is a major target for toxicity by pharmaceuticals and environmental pollutants. Accumulation is known to play an important role in certain nephrotoxicity pathways. Therefore, physiologically-based kinetic and …
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Engineering functional kidney tissue using human iPS cells
… to screen pharmaceutical compounds for potential nephrotoxicity during drug development has always hindered the field of drug development and increased the cost of delivering drugs into the market; in this study, I demonstrate that hiPSCs-derived renal organoids are able to predict nephrotoxicity …
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Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections
… We assessed and compared ICU mortality, nephrotoxicity and time to the first negative culture in the colistin and tobramycin groups.
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Effect of cell- and species-differences in the expression of drug metabolism enzymes on chemical-induced injury to the rat and human kidney
… of the rat and human kidney on chemical-induced nephrotoxicity were studied. Rat renal proximal tubular (rPT) and distal tubular (rDT) cells differed in their susceptibility to trichloroethylene (Tri) and thiophene-containing compounds. These differences were caused in part by differences in the …
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ΠΥΡΕΤΙΚΑ ΕΠΕΙΣΟΔΙΑ ΣΕ ΛΕΥΚΟΠΕΝΙΚΟΥΣ ΑΣΘΕΝΕΙΣ: ΣΥΓΚΡΙΣΗ ΤΗΣ ΑΠΟΤΕΛΕΣΜΑΤΙΚΟΤΗΤΑΣ ΤΩΝ ΣΥΝΔΥΑΣΜΩΝ ΚΑΡΜΠΕΝΙΚΙΛΛΙΝΗΣ/ΓΕΝΤΑΜΙΚΙΝΗΣ ΚΑΙ ΑΖΛΟΚΙΛΛΙΝΗΣ/ΚΕΦΟΞΙΤΙΝΗΣ
… IN 10 AND 2 PATIENTS AS WELL AS REVERSIBLE NEPHROTOXICITY IN 2 AND 1 PATIENTS IN C/G AND A GROUPS RESPECTIVELY. A STATISTICALLY SIGNIFICANT DIFFERENCE BETWEEN A/F AND C/G WAS OBSERVED IN FAVOR OF THE FIRST THERAPEUTIC REGIMEN, WHEN CONSIDERING RESPIRATORY TRACT INFECTION(P < 0,001) AND …
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ORAL ADMINISTRATION OF EPIGALLOCATECHIN-3-GALLATE (EGCG) IS A POTENTIAL THERAPEUTIC FOR CISPLATIN-INDUCED HEARING LOSS
… However, cisplatin-induced neurotoxicity, nephrotoxicity and hearing loss hamper its use in clinical setting. Although, neurotoxicity and nephrotoxicity can be prevented, there is no cure for cisplatin-induced hearing loss. Cisplatin-induced hearing loss results from damage to outer hair …
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Evaluation of liposomal bismuth-ethanedithiol-tobramycin for treatment of cystic fibrosis pulmonary pseudomonas aeruginosa infection
… the IL-8 level in blood and minimized the nephrotoxicity that is associated with aminoglycoside treatment. These results support the hypothesis that aerosolization of liposomal aminoglycosides may enhance the management of chronic lung infections caused by resistant P. aeruginosa in …
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STRUCTURE-ACTIVITY RELATIONSHIPS IN FUNCTIONALIZED PLATINUM-ACRIDINE ANTICANCER AGENTS
… but has proven to have high systemic toxicity (nephrotoxicity). In order to reduce the toxicity of this agent, two new methodologies were developed to reduce unwanted platinum interactions with sulfur-containing biomolecules such as glutathione.
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Characterisation of the synergistic vancomycin-furazolidone action against Escherichia coli : a thesis presented in partial fulfilment of the requirements for the degree of Masters in Biochemistry at Massey University, Manawatū, New Zealand
… a planktonic mode and as a biofilm was above the nephrotoxicity (toxicity in the kidneys) threshold and therefore too high to treat infections with this organism systemically. However, by adding deoxycholic acid to the combination, the bactericidal vancomycin concentration was decreased below the …
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Are gadolinium contrast media really less nephrotoxic than iodine agents in radiographic examinations? A comparison in relation to their ability to attenuate x-rays in a pig model
… Glomerular filtration; Iodine; Kidney failure; Nephrotoxicity. Key words: Angiography; Computed tomography; Contrast media, toxicity; Osmolality; Renal impairment; Gadolinium, Kidney failure; Iodine, nephrotoxicity, equal attenuation, equi-molar, osmotic load, attenuation, half-life, porcine …
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The susceptibility of baboons to the novel immunosuppressant, FTY720
… complications and drug toxicity e.g. nephrotoxicity, remains a serious problem. Since the drugs currently available for allotransplantation preferably target T -cells, and are therefore unlikely to be sufficient for xenotransplantation where there is a strong B-cell driven response, …
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Effect of multiple doses of imidocarb dipropionate on renal and hepatic function of ponies
… are not necessarily indicative of significant nephrotoxicity. It was concluded that four intramuscular treatments of imidocarb dipropionate at a dose of 4 mg/kg every 72 hours may be a relatively safe method whereby persistent Babesia equi infections can be sterilised.
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