Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Nephrotoxicity"”.
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The renal handling and nephrotoxicity of paraquat
Thesis (M.S.)--Michigan State University. Dept. of Pharmacology, 1975
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Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity
… via active secretion and is associated with nephrotoxicity. Currently, prehydration therapy is employed to prevent toxic renal side effects; however it has not been completely ameliorated. The studies described herein aim to determine the mechanism in which cisplatin enters the kidney cell …
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Nephrotoxicity associated with preeclampsia in an Arginine Vasopressin induced rat pregnancy model
Submitted in fulfillment of the requirements for the degree of Doctor of Philosophy: Health Sciences, Durban University of Technology, Durban, South Africa, 2022.
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Isolation of hog renal brush border membrane vesicles with application to the study of cadmium nephrotoxicity
The epithelial cell of the kidney proximal convoluted tubule, like that of the small intestine, consists of two distinct plasma membrane surfaces referred to as the brush border, or luminal surface, and the basal-lateral, or contraluminal surface. Once isolated, membrane vesicles formed from the …
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The Role of Megalin in Aminoglycoside-Associated Toxicity in the Kidney
… aminoglycosides and addressing their associated nephrotoxicity. Subsequent studies show that amikacin accumulates in the kidney during the filtration process and triggers a cascade of cellular events resulting in cell death, acute kidney injury and in some cases, chronic kidney failure. …
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Identification of Early Diagnostic and Predictive Biomarkers of Cisplatin-Induced Acute Kidney Injury Using Metabolomics
… several toxic effects to non-cancerous tissues. Nephrotoxicity is the main dose-limiting toxicity in cisplatin therapy, manifesting as acute kidney injury (AKI) in approximately one-third of patients receiving cisplatin. AKI is defined as an abrupt decline in kidney function and is associated …
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Physiologically-Based Kinetics and Mechanistic Models to Assess Exposure to Chemicals
… computational models exist to investigate nephrotoxicity. However, the kidney is a major target for toxicity by pharmaceuticals and environmental pollutants. Accumulation is known to play an important role in certain nephrotoxicity pathways. Therefore, physiologically-based kinetic and …
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Engineering functional kidney tissue using human iPS cells
… to screen pharmaceutical compounds for potential nephrotoxicity during drug development has always hindered the field of drug development and increased the cost of delivering drugs into the market; in this study, I demonstrate that hiPSCs-derived renal organoids are able to predict nephrotoxicity …
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Safety and effectiveness of colistin compared with tobramycin for multi-drug resistant Acinetobacter baumannii infections
… We assessed and compared ICU mortality, nephrotoxicity and time to the first negative culture in the colistin and tobramycin groups.
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Effect of cell- and species-differences in the expression of drug metabolism enzymes on chemical-induced injury to the rat and human kidney
… of the rat and human kidney on chemical-induced nephrotoxicity were studied. Rat renal proximal tubular (rPT) and distal tubular (rDT) cells differed in their susceptibility to trichloroethylene (Tri) and thiophene-containing compounds. These differences were caused in part by differences in the …
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ΠΥΡΕΤΙΚΑ ΕΠΕΙΣΟΔΙΑ ΣΕ ΛΕΥΚΟΠΕΝΙΚΟΥΣ ΑΣΘΕΝΕΙΣ: ΣΥΓΚΡΙΣΗ ΤΗΣ ΑΠΟΤΕΛΕΣΜΑΤΙΚΟΤΗΤΑΣ ΤΩΝ ΣΥΝΔΥΑΣΜΩΝ ΚΑΡΜΠΕΝΙΚΙΛΛΙΝΗΣ/ΓΕΝΤΑΜΙΚΙΝΗΣ ΚΑΙ ΑΖΛΟΚΙΛΛΙΝΗΣ/ΚΕΦΟΞΙΤΙΝΗΣ
… IN 10 AND 2 PATIENTS AS WELL AS REVERSIBLE NEPHROTOXICITY IN 2 AND 1 PATIENTS IN C/G AND A GROUPS RESPECTIVELY. A STATISTICALLY SIGNIFICANT DIFFERENCE BETWEEN A/F AND C/G WAS OBSERVED IN FAVOR OF THE FIRST THERAPEUTIC REGIMEN, WHEN CONSIDERING RESPIRATORY TRACT INFECTION(P < 0,001) AND …
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ORAL ADMINISTRATION OF EPIGALLOCATECHIN-3-GALLATE (EGCG) IS A POTENTIAL THERAPEUTIC FOR CISPLATIN-INDUCED HEARING LOSS
… However, cisplatin-induced neurotoxicity, nephrotoxicity and hearing loss hamper its use in clinical setting. Although, neurotoxicity and nephrotoxicity can be prevented, there is no cure for cisplatin-induced hearing loss. Cisplatin-induced hearing loss results from damage to outer hair …
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STRUCTURE-ACTIVITY RELATIONSHIPS IN FUNCTIONALIZED PLATINUM-ACRIDINE ANTICANCER AGENTS
… but has proven to have high systemic toxicity (nephrotoxicity). In order to reduce the toxicity of this agent, two new methodologies were developed to reduce unwanted platinum interactions with sulfur-containing biomolecules such as glutathione.
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Are gadolinium contrast media really less nephrotoxic than iodine agents in radiographic examinations? A comparison in relation to their ability to attenuate x-rays in a pig model
… Glomerular filtration; Iodine; Kidney failure; Nephrotoxicity. Key words: Angiography; Computed tomography; Contrast media, toxicity; Osmolality; Renal impairment; Gadolinium, Kidney failure; Iodine, nephrotoxicity, equal attenuation, equi-molar, osmotic load, attenuation, half-life, porcine …
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The susceptibility of baboons to the novel immunosuppressant, FTY720
… complications and drug toxicity e.g. nephrotoxicity, remains a serious problem. Since the drugs currently available for allotransplantation preferably target T -cells, and are therefore unlikely to be sufficient for xenotransplantation where there is a strong B-cell driven response, …
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Effect of multiple doses of imidocarb dipropionate on renal and hepatic function of ponies
… are not necessarily indicative of significant nephrotoxicity. It was concluded that four intramuscular treatments of imidocarb dipropionate at a dose of 4 mg/kg every 72 hours may be a relatively safe method whereby persistent Babesia equi infections can be sterilised.
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Incidence and Prevalence Of Renal Dysfunction In Antiretroviral Therapy (ART) Naïve Patients Starting A Tenofovir (TDF) Based ART Regimen In Mitchell's Plain Community Health Centre (CHC) ARV Clinic
… pattern of occurence and associated factors of nephrotoxicity in patients initiated on TDF based ART regimen in Mitchell's Plain CHC ARV Clinic and make recommendations. Methodology: The study was conducted by reviewing retrospective records of all ARV naïve HIV positive adults initiated on TDF …
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Likelihood of development renal dysfunction after one year of treatment with tenofovir(TDF) in HIV/AIDS patients at the UTH: An analytical cross-section study
… has been associated with renal tubulopathy and nephrotoxicity in many studies. In Zambia, TDF has been in use since 2007. This study was set out to determine whether TDF had similar Nephrotoxic effects in patients receiving TDF- based regimen at the largest Antiretroviral Therapy (ART) Centre in …
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Effekte stromafreier Hämoglobinlösungen auf die Mikrozirkulation im quergestreiften Rückenhautmuskel beim Hamster
… has failed due to different issues such as nephrotoxicity, systemic activation of complement cascade, vasoconstriction and other side effects. To prove the in vivo safety and efficiency of the solutions available to date, quantitative analysis of the microcirculation is needed as a crucial …
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