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Showing 1 to 14 of 14 for “"Nephrons"”.
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The Role of Daam1 In Kidney Development
… of epithelial tubules. Kidney tubules are called nephrons, and their morphology is important for kidney function. Nephrons develop from mesodermally derived aggregates of progenitor cells. The nephric progenitors organize into nephric tubules lined with hair-like sensory projections called cilia. …
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The Role of Daam1 In Kidney Development
… of epithelial tubules. Kidney tubules are called nephrons, and their morphology is important for kidney function. Nephrons develop from mesodermally derived aggregates of progenitor cells. The nephric progenitors organize into nephric tubules lined with hair-like sensory projections called cilia. …
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A Dynamical Nephrovascular Model of Renal Autoregulation
… main functions of the kidney take place in the nephrons. For their proper operation, nephrons need to be supplied with a stable blood flow that remains constant despite fluctuations of arterial pressure. Such stability is provided by the afferent arterioles, which are unique vessels in the …
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Balancing Renewal and Differentiation of Progenitor Cells in the Developing Kidney
… through individual functional units called nephrons. While nephron number may decrease during one's lifetime (due to various kidney injuries or hypoxic events), new nephrons do not form in adults. This is most likely due to the absence of nephron precursor cells. If nephron number falls …
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Kidney tubulogenesis in human renal organoids: an investigation into the contribution of the microtubule-associated protein DCDC2
… initial tube which subsequently extends into the nephrons, which are the functional unit of the kidney. When kidney nephrons are lost due to disease or damage, kidney function is reduced because the total number of nephrons in an individual is formed pre-natally and nephrons cannot be added after …
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The Novel Role of Dnmbp In Kidney Development
… of up to a million epithelial tubules called nephrons. Disruption of nephron development is one of the many congenital anomalies that cause CAKUT, often resulting in chronic or end-stage renal disease which requires transplant. During nephron epithelialization, the formation of stable …
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The renal effects of nonsteroidal anti-inflammatory drugs (NSAIDS) in dogs with chronic kidney disease (CKD)
… risk for NSAID-related adverse drug effects. As nephrons and renal reserve are lost in chronic kidney disease, the canine kidney becomes more dependent on COX-2 for production of prostaglandins. Inasmuch as the prevalence of both CKD and OA increases with age, it is expected that many dogs being …
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Single nephron structure and function, and renal effects of catecholamines in the dogfish, Scyliorhinus canicula
… Adrenaline decreased the proportion of filtering nephrons. 12. The role of circulating catecholamines is discussed in relation to the regulation of renal circulation.
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Exploring the impact of maternal obesity on offspring renal morphology and later life health
… diet typically display a reduced number of nephrons and increased glomerular areas. No studies to date have investigated the effect of maternal obesity on early life kidney and glomerular morphology. To address this, as part of this thesis, kidney morphology was assessed at weaning in male …
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PARATHYROID HORMONE ACTIVITY AND RELATED CLINICOPATHOLOGICAL ALTERATIONS IN DOGS AFFECTED WITH CHRONIC KIDNEY DISEASE
… (CKD). RHPT is promoted mainly by the loss of nephrons and consequent hyperphosphatemia and its severity increases in parallel to the disease. The identification and management of RHPT are suggested in dogs affected with CKD, to establish promptly appropriate treatments and follow the …
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Engineering functional kidney tissue using human iPS cells
… of the functional abilities of the induced nephrons is key to the use of these organoids in any application. Here, I show that hiPSC-derived renal organoids possess proximal tubular transporters and receptors; I present optimised techniques to assess the function of these receptors in-vitro …
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Using human induced pluripotent stem cells to model cystinosis
… into avascular kidney organoids comprised of 3-5 nephrons with renal tubules consisting of distinct proximal and distal segments and primitive glomeruli containing podocytes. Using this protocol, CTNS-iPS cells were differentiated into cystinotic kidney organoids and found to accumulate large …
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Nebulizer facilitated molding of freeform 3D printed sacrificial scaffolds for breast tumor microenvironment tissue engineering
… scale features (ductal acini, capillaries, nephrons, etc.) do not easily scale to larger structures, while models of large structures fail to replicate intrinsic minute details. Sacrificial molding can be used to create tubular systems. Common molding techniques, however, lack spatial …
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Characterizing Renal Interstitial Heterogeneity and Its Role in Nephron Patterning
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.