Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Nephroblastoma"”.
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The diversity of malignant rhabdoid tumours : a morphological, immunohistochemical and ultrastructural review of cases from the Red Cross Children's Hospital and Groote Schuur Hospitals
… tumours, and their apparent relationship to nephroblastoma is still unclear, careful assessment of new cases is required. This investigation illustrates diverse ultrastructural, light microscopic and immunohistochemical findings. These features are related to each other and to the biological …
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The role of Wt1 in Müllerian duct development
… mutations of <em>WT1</em> lead to pediatric nephroblastoma as well as frequent differences of sex development (DSDs). Previous studies have suggested that WT1 acts as an activator for <em>Amhr2</em>, a necessary component of typical male differentiation. We used the mouse as a model to …
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Multiscale Modeling Of Cell Fate Switching To Predict Patient-Specific Response To Combination Cancer Therapy
… to different specific treatment combinations in nephroblastoma. Such methods have great potential to advance our understanding of the determinants of cellular identity and its loss in cancer, and in turn our ability to personalize patient care.
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Roles of CCN5 in regulating progression and therapeutic sensitivity of breast cancer
… Cysteine-rich 61-Connective Tissue Growth Factor-nephroblastoma-overexpressed 5 (CCN5) induces growth arrest of TNBC cells in-vitro and in xenograft tumors. Our studies show that after being secreted into the extracellular matrix, CCN5 binds to the α6β1 integrins of the cells leading to inhibition …
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Identification, Validation and Implementation of Blastemal Biomarkers in Wilms Tumour
The aim of this thesis has been to establish biomarkers for the blastemal element in Wilms tumour (WT) – the most common paediatric kidney cancer. Blastema is, together with epithelium and stroma, one of the three common histological elements of WT. WTs dominated by blastema after preoperative …
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Mechanisms and Consequences of Chromosomal Instability in Malignant tumours
In this thesis, telomere deficiency with subsequent anaphase bridging was found to be associated with chromosomal instability in established colorectal cancer cell lines and in Wilms tumour. In colorectal cancer cell lines, anaphase bridging was observed to generate both numerical and structural …