Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"Neovascularization"”.
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Polymeric materials for neovascularization
… of the increasing complexities involved with neovascularization applications. To resolve these challenges, this work aims to design a wide variety of proangiogenic biomaterial systems with tunable properties used for neovascularization therapies. This thesis describes the design of several …
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Three dimensionally flocculated proangiogenic microgels for neovascularization
Microparticles encapsulating regenerative medicines have been used in tissue engineering because of their several advantages, including non-invasive drug delivery and controllable drug release rates. However, microparticles implanted in tissue defects are readily displaced by external mechanical …
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Multi-Scale Osteointegration and Neovascularization of Biphasic Calcium Phosphate Bone Scaffolds
… forming cells have potential for promoting neovascularization in a bone defect when combined with rhBMP-2.
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TWEAK/Fn14 Pathway is Activated by Hypoxia and is a Novel Mediator of Retinal Neovascularization
Retinal neovascularization (NV) is a major cause of vision loss in vascular eye diseases such as diabetic retinopathy, retinal vein occlusion and retinopathy of permaturity. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor inducible 14 …
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Role of p53 and its isoforms in the expression of FGF-2 and tumoral neovascularization
The tumour suppressor p53 actually exists as 9 protein isoforms. Among them, D133p53a, b and g result from the use of an alternative promoter and lack the N-terminal transactivation domain. In addition to its multiple functions maintaining cell integrity, p53 is also able to block angiogenesis, a …
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Corticosteroid-Encapsulated Nanoparticles in Thermoreversible Gels for the Amelioration of Choroidal Neovascularization in Age-Related Macular Degeneration
… (wet) AMD, is characterized by intraocular neovascularization, inflammation, and retinal damage; however, the disease progression can be deterred through intraocular injections of anti-angiogenic agents. The complications and burden that arise from repetitive injections as well as the …
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The traditionally protective cystathionine gamma-lyase/hydrogen sulfide pathway contributes to pathological retinal neovascularization in oxygen-induced retinopathy
… pathway in ischemia-induced pathological retinal neovascularization (NV). C57BL/6 CSE -/- and +/- littermates were exposed to 75% oxygen from postnatal day (P)7 to P12 causing vaso-obliteration (VO). Mice were returned to room air, creating relative hypoxia and spurring retinal NV until sacrificed …
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Nanofiber-based therapy for diabetic wound healing: a mechanistic study
… Diminished infiltration of new blood vessels (neovascularization) into the wound is a major factor contributing to the impaired healing of diabetic ulcers. A previous study has shown that the wounds treated with RAD16-II peptide nanofibers resulted in increased infiltration of both endothelial …
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Evaluation Of HIF Inhibitors For The Treatment of Ocular Neovascular Diseases
… hypoxia is the fundamental cause of pathological neovascularization in ocular diseases and cancers. Thus, the inhibitors of the HIF pathway or key regulators such as histone demethylases (KDMs), that amplify HIF signaling, can have profound therapeutic value for these diseases. This dissertation …
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Optical Coherence Tomography Angiography for Imaging and Analysis of the Choriocapillaris in Late Age-Related Macular Degeneration
… focus on choriocapillaris impairment in macular neovascularization and geographic atrophy, the two subtypes comprising late AMD. The choriocapillaris, the capillary layer of the choroid, is responsible for nourishing the outer retina, including the photoreceptors, and has long been hypothesized …
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Multifunctional bioactive polymers for the fabrication of tissue engineering scaffolds and the treatment of tissue ischemia
… for refined cell culture, encapsulation, and neovascularization, including: polymeric cross-linkers which tunes the elastic modulus and swelling ratio of hydrogels in a more independent manner (Chapter 2); fibronectin or fibronectin fragments in fibrin gels to improve neovascularization …
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Development of a Vascularized Carotid Artery Plaque Phantom for the Investigation of Novel Ultrasound-Based Technologies
… by a large lipid core, a thin fibrous cap, and neovascularization – features that increase the risk of plaque rupture and thrombosis. Intraplaque neovascularization (IPN) in advanced lesions in the carotid artery can be visualized using contrast-enhanced ultrasound (CEUS) technology, and its …
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Role of ephrinB2 and EphB4 in mouse retinal angiogenesis
… prepared after fluorescein-dextran perfusion and neovascularization features were quantified in a blinded fashion. The criteria taken into account were blood vessel tuft formation, extraretinal neovascularization, non-perfusion areas, tortuosity of the vessels and neovascularization of the optic …
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Heparan sulfate glycosaminoglycan regulation of vasculogenesis
Neovascularization is an essential process to repair ischemic tissues following myocardial infarction, stroke, diabetic complications, or transplant procedures. Blood vessels are generated by distinct vasculogenic and angiogenic processes. Although multiple proangiogenic factors have been …
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Investigations into the stability of growth factor induced-vasculature and the effects of synthetic biomaterials on heart remodelling after myocardial infarction
… lead to an improved strategy for therapeutic neovascularization. To test this hypothesis, a novel in vivo model system that allows for characterization of stability and mural cell investment of newly created vessels was designed.
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DESIGNER COLLAGEN-FIBRIL BIOGRAFT MATERIALS FOR TUNABLE MOLECULAR DELIVERY
… field still awaits biograft designs that enable neovascularization at clinically relevant size scales. Critical to the design of such materials are tissue-specific physico-mechanical properties and controlled local therapeutic molecular release.
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MICRO-CT EVALUATION OF MSC/HUVEC/HSC-MEDIATED ANGIOGENESIS IN LARGE PCL-ßTCP CONSTRUCTS IMPLANTED IN NUDE MICE
… than MSC or MSC-HSC constructs. Furthermore, neovascularization in the cell free construct was limited to the surface of the construct. The development of neovascularization from noninvasive sources constitutes an important step in the development of clinical strategies for tissue …
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Targeted drug delivery within the eye
… using coated microneedles to suppress corneal neovascularization in a rabbit model. The data show that highly targeted delivery of the anti-vascular endothelial growth factor protein therapeutic gave a better biological response of suppressing neovascularization with 11,900 times less dosage …
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Design and Application of Chitosan/biphasic Calcium Phosphate Porous Scaffolds for Bone Tissue Engineering
… bFGF release from the constructs improved neovascularization in the defect area and subsequently enhanced new bone formation. Although the rate and extent of bone formation was similar in bFGF group to those in empty defects for the period of the study, existence of woven bone in bFGF group …
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