Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Neoplastic transformation"”.
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Novel Rac1/Stat3 and Stat5 Pathway in Differentiation and Neoplastic Transformation of Breast Epithelial Cells: Potential Prognostic Markers
… of the balance between differentiation and transformation of breast epithelial cells: Stat3 activation is modulated by a cadherin/Rac1 pathway, and this may be necessary for differentiation. Stat5 on the other hand may play a role in differentiation independent of cell density. Therefore, …
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Transformation of human melanocytes and mechanisms of melanoma metastasis
… melanocyte-specific factors present prior to neoplastic transformation can play a pivotal role in governing melanoma's progression.
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Žmogaus mezenchiminių kamieninių ląstelių genetinių savybių tyrimas saugiai terapijai užtikrinti /
… Moreover, such MSCs can undergo spontaneous neoplastic transformation with karyotype changes. To date no molecular markers of MSC senescence are available and the tumorigenic potential of MSCs has become the most important concern for safe clinical use of MSCs. This study revealed a normal …
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Investigation of human mesenchymal stem cell genetic characteristics to ensure therapy safety /
… Moreover, such MSCs can undergo spontaneous neoplastic transformation with karyotype changes. To date no molecular markers of MSC senescence are available and the tumorigenic potential of MSCs has become the most important concern for safe clinical use of MSCs. This study revealed a normal …
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Insights into transcriptional regulation from natural and induced variation in closely related species
… such as higher-order genome organisation or the neoplastic transformation of a tumour cell in cancer development. In the first part of the thesis, I explore the evolutionary dynamics of the CTCF (CCCTC-binding factor) binding among mouse species and its interplay with the establishment and …
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Gsk3Beta-Mediated Ezh2 Phosphorylation Suppresses Methylation of H3K27 and Ezh2’S Oncogenic Functions
… cellular processes. GSK3b also participates in neoplastic transformation, tumor development and regulate cancer cell metastasis. Inactivation of GSK3b contributes to tumor development in certain types of cancers, such as breast cancer. In this study, we found that GSK3b negatively regulates …
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Identificazione e Validazione di Hotspot di Metilazione del DNA come Biomarcatori per il Melanoma Cutaneo
… cellular and molecular processes underlying the neoplastic transformation of melanocytes. Among the epigenetic alterations, DNA methylation represents the non-structural modification of DNA mainly involved in the alteration of the expression levels of genes potentially responsible for the loss of …
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TRANSFORMATION OF PRIMARY HUMAN HEPATOCYTES IN HEPATOCELLULAR CARCINOMA
… cancer. Currently, there is limited knowledge of neoplastic transformation of hepatocytes in HCC. In clinical practice, the high rate of HCC local recurrence suggests the presence of different hepatocyte populations within the liver and particularly in the tumor proximity. This study aims to …
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UNCOVERING THE MOLECULAR BASIS FOR FATTY ACID SYNTHASE PRODUCT SPECIFICITY: STRUCTURAL AND KINETIC EVALUATION OF THIOESTERASE I AND THIOESTERASE II
… lipogenesis of LCFAs via FASN is a hallmark of neoplastic transformation. Therefore, FASN has been firmly established as a target for pharmaceutical intervention in several cancers, including lung, colon, prostate, ovarian and breast. Current drug discovery strategies have succeeded in killing …
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Chronic oxidative stress and susceptibility to renal carcinogenesis
… of H2O2-induced chronic oxidative stress on neoplastic transformation of normal human kidney epithelial cells. To achieve our study goals, we developed an in-vitro cell model by exposing the HK-2 cells (immortalized normal human kidney epithelial cells) to H2O2 for 6 months and then evaluated …
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Elucidating Purinergic and Pro-inflammatory Signaling Mechanisms in Breast Cancer
… tissue-specific microenvironments that stimulate neoplastic transformation and malignancy. Tumor-acquired hallmarks that maintain functional plasticity frequently result from intrinsic genomic aberrations leading to transcriptional dysregulation. Concomitantly, tumor-stromal interactions promote …
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Alveolar stem cell dynamics and regulatory mechanisms in homeostasis and early oncogenesis
… to shed insight into the early events driving neoplastic transformation. By integrating immunofluorescent analysis with 3D reconstruction and mathematical modelling of AT2- derived clones, I describe the presence of two independent AT2 subpopulations regulated by distinct dynamics. I show that …
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Prevalence and fate of pro-oncogenic clones in the human colon
… does not dictate the Availability of clones for Neoplastic Conversion (ANC). For example, TP53 clones had the highest event burden in the normal tissue but KRAS clones had a higher ANC. Some of the factors that could be contributing to the differential fate of pro-oncogenic clones were …
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Quantifying Intestinal Stem Cell Dynamics Using Microsatellite Sequencing
… mutation can predispose the epithelium to neoplastic transformation. Understanding the factors that govern these dynamics will give insight into the early stages of oncogenesis. Continuous clonal labelling, whereby DNA strand slippage leading to the contraction or expansion of a …
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Role of Jak/Stat pathway in the pathogenesis of breast cancer
… Aberrant activation of this pathway mediates neoplastic transformation and abnormal growth of many malignancies including breast cancer, the most common cancer among women, and the second leading cause of cancer deaths in women in United States. The mechanism by which the Jak/Stat pathway …
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The microbiota and colon cancer risk: cause or consequence?
… model of sporadic CRC prior to detection of host neoplastic transformation. The microbiota present in the gut of our familial model also differs prior to the onset of disease with the potential to contribute to disease initiation. Our longitudinal studies also identified a distinct set of …
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Aberrant Ras/MAPK signaling in skeletal development
… has been studied intensively in the context of neoplastic transformation. Other studies have focused on the roles of this pathway during development and have modeled syndromes, such as Noonan Syndrome (NS), that are caused by aberrant germline Ras/MAPK signaling. One hallmark of these …
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Strategies for Oncogenesis by Avian Leukosis Viruses
… transform cells in tissue culture and that cause neoplastic disease only after a latent period of 4-12 months. ALVs generally induce widely disseminating B cell lymphomas originating in the bursae of Fabricius of infected birds. Occasionally, they cause other neoplasms such as sarcomas, carcinomas …
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The Cellular and Molecular Dynamics of the Queuosine Modification in Transfer RNA: Definition, Modulation, Deficiencies and Effect of the Queuosine Modification System
… normal modification is strongly correlated with neoplastic transformation and tumor progression of a wide variety of cancers.</p> <p>The "normal" system for formation of the queuosine modification in tRNA was studied in human fibroblast cell cultures and in mouse, rat and human liver tissues. The …
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Steroid signalling in the human ovarian surface epithelium wound healing
… hOSE cells, suggestive of an acquired feature of neoplastic transformation. However, both transcripts could be restored after IL-4 treatment, attesting a therapeutic advantage of this cytokine. In conclusion, we have shown that 3β-HSD is under inflammatory control during ovarian post-ovulatory …
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