Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Neoplasm Proteins"”.
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MEIS1: At the Crossroads Between Metabolic and Cell Cycle Regulation
Stem cells undergo self-renewal, maintaining themselves in an undifferentiated state while generating differentiated cells that are required for the tissue homeostasis or repair. One intriguing feature of stem cells is their maintenance in their respective hypoxic niche. Survival in this low-oxygen …
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Thioredoxin-1 Inhibition Promotes MLKL Activation: Biochemical Insights Into a Suppressor of the Necroptotic Pathway
… strategy for identifying novel MLKL interacting proteins. Immunoprecipitation of NSA crosslinked MLKL complexes followed by mass spectrometric analysis revealed Thioredoxin-1, an essential cytosolic thiol oxidoreductase, to be a potential MLKL regulator. Based on its ability to reduce disulfide …
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p14ARF : A p53-Independent Tumor Suppressor
… to a cancerous phenotype. This locus encodes two proteins, p16 and p14, that play a pivotal role in tumor surveillance.</p> <p>Breakdowns in the p14 pathway have been estimated to be present in approximately 40% of human cancers and only recently have its binding partners and effects begun to be …
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LKB1, CCL2, and Macrophages: A New Axis of Endometrial Cancer Progression
Cancer of the uterus is a common malignancy in women with no adequate treatments for tumors that have progressed beyond the uterus. The serine-threonine kinase LKB1 has been identified as a potent suppressor of uterine cancer. Combined genetic, proteomic, and in vivo studies in genetically …
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The Cancer Specific Ubiquitin Ligase MAGE-A3/6-TRIM28 Drives Tumorigenesis by Ubiquitination and Proteasomal Degradation of AMPK
The genes MAGE-A3 and MAGE-A6 (MAGE-A3/6) have a unique expression pattern in which they are normally expressed in the adult testis but are aberrantly expressed in cancer. It is known that when expressed in cancer, MAGE-A3/6 is a negative prognostic indicator and cancer cells are dependent on it …
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Biochemical Characterization of IpaH E3 Ubiquitin Ligase Effector Proteins and Their Host Substrates
… 3 secretion system (T3SS) to inject effector proteins in the cytoplasm of host cells to manipulate host cells processes. T3SS effectors are able to post translationally modify host proteins to reprogram intracellular signaling pathways, actin dynamics, membrane trafficking, and innate immune …