Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Neonatal Fc receptor"”.
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Transepithelial transport of nanoparticles targeted to the neonatal Fc receptor for oral delivery applications
… limits efficient oral delivery of NPs. The neonatal Fc receptor (FcRn) mediates IgG antibody transport across epithelial barriers. It was discovered as the receptor in the neonatal intestine that transports IgG in breast milk from mother to offspring. However, FcRn is expressed into …
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Targeting the Neonatal Fc Receptor, FcRn, to Treat Autoimmunity and Elucidation of Sites of FcRn Function
The neonatal Fc receptor, FcRn, is expressed in many different cell types and serves several functions, some of which are cell type-specific. A function common to most cell types that express this receptor is salvage of IgG from cellular degradation which is responsible for the long in vivo …
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Rational engineering strategies to improve antibody fragment pharmacokinetics and bioavailability
… factors, including an inability to bind the neonatal Fc receptor (FcRn) – the receptor responsible for the long half-lives of natural IgG and serum albumin. A common approach to circumvent these limitations is to enable engagement with the half-life extending neonatal Fc receptor (FcRn). This …
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THE FUNCTIONAL REGULATION OF FCRN EXPRESSION AND FCRN-MEDIATED ANTIGEN PRESENTATION
The neonatal Fc receptor for IgG (FcRn), a major histocompatibility complex (MHC) class I-related molecule, plays an important role in IgG transport and protection. The transport of IgG across epithelial and endothelial barriers and the IgG homeostasis maintained by FcRn contributes to the …
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Modeling approaches to characterize the disposition of monoclonal antibodies
… of the non-specific elimination involving the neonatal Fc receptor (FcRn) and endogenous IgG (IgGendo). The remarkable discrepancy between the simplicity of biodistribution data and the complexity of published PBPK models translates in parameter identifiability issues. In this thesis, we …
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Subcellular Fractionation Methods for the Quantification of Endogenous Protein in Human Liver Using Targeted Proteomics
… liver endogenous proteins. First, human liver neonatal Fc receptor and beta 2-microglobulin were enriched in a post-nuclear supernatant, and a UPLC-MRM method was developed and validated to quantify these two proteins. Our quantitative results and determination of interindividual variability …
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Determinants of antibody specificity
… variable-region mediated effects independent of neonatal Fc receptor (FcRn) binding. Focused on the antibody variable region, we next utilized our nonspecificity assay as a sorting tool to look at a naive repertoire library. We found significant nonspecificity in the VH6 class of antibodies, …
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Characterization of Fc receptor family proteins in vaginal and endocervical epithelia
… of my research project was to characterize Fc receptor expression in epithelial cell models of the lower female genital tract with a particular focus on the neonatal Fc receptor (FcRn). Fc receptors are a large family of proteins that bind to the Fc region of immunoglobulins (Igs) and …
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Challenges in the Pharmacokinetics of Therapeutic Proteins
… disposition (TMDD) and 2) the ontogeny of the neonatal Fc receptor (FcRn) expression along with its effect on the pharmacokinetics of monoclonal antibodies (mAbs) during development.</p> <p>TMDD often well describes the pharmacokinetics of therapeutic proteins that have high specificity and …