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Showing 1 to 20 of 22 for “"Neointima"”.

  1. Characterization of the Mechanism of PPARγ-Mediated Neointima Formation in Rodents

    Tsukahara, Ryoko2016

    … the LPA receptor subtypes necessary for the neointimal response in a non-injury model of carotid remodeling and also compared the effects of AGP and the PPARγ agonist rosiglitazone (ROSI) on balloon injury-elicited neointima development. In the balloon injury model AGP significantly increased …

    tenn-hsc Repository record

  2. Vergleichende Untersuchung der Wirkung verschiedener HMG-CoA Reduktase Inhibitoren auf die Apoptose normaler und neointimaler Gefäßmuskelzellen

    Hristov, MihailLudwig-Maximilians-Universität

    … selektive Induktion von Apoptose in Zellen der Neointima zur Restenose-prävention ist ein besseres Verständnis der Apoptoseregulation in glatten Gefäßmuskelzellen erforderlich. In dieser Arbeit wurden glatte Gefäßmuskelzellen aus Media und Neointima der Ratte im Hinblick auf ihre Empfindlichkeit …

    lmu-germany Repository record

  3. Untersuchungen zur Beteiligung von p38 MAPK beim Remodelingprozeß nach Myokardinfarkt in vivo und bei der Fibronektinexpression in Rahmen der Neointima - Entstehung nach Angioplastie in vitro

    Berova, Marinela GueorguievaUniversität Würzburg

    … und bei der Fibronektin-Expression in Rahmen der Neointima- Entstehung nach Angioplastie in vitro durchgeführt. Im Bereich der kardiovaskulären Forschung hat die Familie der Mitogen Aktivierten Protein Kinasen besonderes Interesse gewonnen. Sie besteht aus drei Subgruppen - JNK, ERK und p38 MAPK. …

    wurz-thes Repository record

  4. A translational approach to understanding cellular responses to vascular injury

    Sedovy, MeghanVirginia Tech2025

    … drove excessive proliferation leading to neointima formation and vascular blockage. A Johnstone lab developed peptide that targets this phosphorylation state prevents neointima formation in mouse and human tissues. These findings highlight a role for Cx43 phosphorylation by MAPK in …

    vt Repository record

  5. Vascular smooth muscle cell heterogeneity and plasticity in models of cardiovascular disease

    Chappell, JoelUniversity of Cambridge2018

    … used to demonstrate that VSMCs in injury-induced neointimal lesions and in atherosclerotic plaques are oligo-clonal, derived from few expanding cells, within mice. Lineage tracing also revealed that the progeny of individual VSMCs contribute to both alpha Smooth muscle actin (aSma)-positive …

    cambridge Repository record

  6. Polo-Like Kinase 1 and Smooth Muscle Cells in Coronary Artery Bypass Conduits and Coronary Arteries Following Angioplasty

    Sur, SwastikaCreighton University2016

    … (SV) graft is prone to undergo restenosis due to neointima formation. However, the underlying mechanism in vein-graft that makes it prone to stenosis and closure is unknown. In this study, we examined the role of polo-like kinase (PLK)-1 in the PLK1/pPLK1-pCDK1-p-Histone H3 pathway in mediating …

    creighton Repository record

  7. In Vitro and In Silico Study of Deposition on Textured Biomaterials: Towards Biofunctionalization of Ventricular Cannula

    He, WenxuanCornell University2025

    … decades have been highly variable, ranging from neointima to thrombus. Chapter 2 addresses this ambiguity by introducing a unified taxonomy for biological response to sintered titanium in LVADs, distinguishing neointima---with anti-thrombogenic endothelium--- from pannus, pseudoneointima, and …

    cornell Repository record

  8. Einfluß der Atherosklerose auf den NO:cGMP Signalweg am Modell des cholesteringefütterten Kaninchen

    Melichar, Volker O.Universität Würzburg

    … ist vor allem in der neugebildeten Neointima reduziert. P-VASP, ein Indikator der Aktivität des gesamten NO:cGMP-Signalwegs, ist in eindrucksvoller Weise reduziert. Die Enzyme des NO-unabhängigen Teils des NO:cGMP-Signalwegs werden in zunehmenden Maße pharmakologisch beeinflußbar. …

    wurz-thes Repository record

  9. Die Bedeutung von Entzündung und reaktiven Sauerstoffspezies in der Intimahyperplasie

    Kamann, StefanieUniversität Potsdam

    … des Gefäßes ist die Bildung einer Neointima durch die Proliferation transdifferenzierter vaskulärer glatter Muskelzellen und die Sekretion extrazellulärer Matrix. Die Entstehung reaktiver Sauerstoffspezies (ROS) und die Entzündungsreaktion nach der Gefäßverletzung werden als frühe, …

    potsdam-diss Repository record

  10. Protective Immunity in Atherosclerosis

    Wigren, MariaExperimental Cardiovascular Research Unit, Lund University2011

    … reduced atherosclerosis development, whereas, neointima formation in response to vascular injury was accelerated by CD1d lipid antigen presentation. NKT cells and CD1d could therefore be an additional potential target in immune modulating therapies. Except for novel therapies, new biomarkers to …

    lund Repository record

  11. Novel strategies for optimising drug release from medicinal implants

    Galluzzo, AnnaUniversity of Strathclyde2012

    … and migration, resulting in the development of a neointima, which renarrows the artery lumen. Drug-eluting stents (DES) release drugs to inhibit SMC proliferation and have been very successful in reducing ISR rates. However, they are not suitable for every patient group and lesion type, and may …

    strathclyde Repository record

  12. Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation.

    Skene, Karen E.Robert Gordon University2010

    Neointimal formation is a complex process that occurs due to the over compensatory healing response produced by the vessel following injury. Three key events, SMC proliferation, SMC migration and the inflammatory response, occur in unison to drive the formation of a neointima. …

    rgu Repository record

  13. Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders

    Dimitrijevic, IvanDepartment of Internal Medcine, University Hospital of Lund,2010

    … in the VSMC in the medial layer as well in the neointima in affected arteries. 6. ETB receptors mediate contraction of subcutaneous resistance arteries in ischemic heart disease. The present thesis demonstrated that there is increased ETB and AT1 receptor expression in VSMC in ischemic heart …

    lund Repository record

  14. Einfluß der Photodynamischen Therapie auf die Neointimabildung vor und nach Stentimplantation in die Arteria femoralis des Hausschweines

    Valassis, GrigoriosLudwig-Maximilians-Universität

    … um einen möglichst günstigen Effekt auf die Neointimafläche zu erzielen. Material und Methode: Es wurden drei Gruppen untersucht. Die Kontrollgruppe (Gruppe K), bei der jeweils ein Stent in die Arteria femoralis implantiert wurde, eine „1.Stent+2.PDT“-Gruppe (Gruppe A), die zuerst einer …

    lmu-germany Repository record

  15. Spatiotemporal controlled delivery of nanoparticles to injured vasculature

    Chan, Juliana MariaMassachusetts Institute of Technology2010

    … on Day I and 6 and resulted in lower neointima-to-media (N/M) scores at two weeks compared to FDA-approved Taxol@ and injury-only groups (N/Msham= -249 + 0.046, vs. N/MTaxol=0.837 ± 0.087, N/MNP=0.749 ± 0.136 and N/MPep-NP=0.662 ± 0.169, all P < 0.01 vs. injury-only, mean ± SEM, n=5). …

    mit Repository record

  16. Experimentelle Untersuchungen am porzinen „over-sized coronary stent“-

    Reimer, CorneliaLudwig-Maximilians-Universität

    … stents. The injury score (IS) and the measured neointimal area (NF) were significantly higher in the group of niob-zirkonium stents coated with iridiumoxide. The histomorphometric and angiographic parameters of restenosis did not point out any significant difference between the test groups. The …

    lmu-germany Repository record

  17. Development of bioabsorbable braided vascular scaffolds for the intracranial circulation

    Jamshidi, MehdiSchulich School of Engineering2019

    … aneurysms is only temporary, due to progressive neointima formation over the stent structure, they cannot be removed. This requires patients to remain on lifelong anti-platelet medications, which can cause other health problems. Bioabsorbable stents have been postulated as a way to overcome the …

    calgary Repository record

  18. Transcriptional regulation of the Human Zfm1/Sf1 Gene

    Nogoy, Nicole Alberta2012

    … Konzepts führen um die Bildung der Neointima in betroffenen Gefäßen zu verlangsamen oder zu verhindern.

    goettingen Repository record

  19. Impact of Percutaneous Transluminal Intervention on Vascular Hypoxia and the Role of Micro-calcifications on Atherosclerotic Plaque Rupture

    Corti, Andrea2022

    … 10% of PTI procedures are followed by severe Neointima Hyperplasia (NH), which causes a new occlusion and failure of the implant. A significant precursor of NH appears to be PTI-induced vascular hypoxia, but the reason for this drop in oxygen tension remains unclear. On the other hand, …

    cuny Repository record

  20. Ενδοαγγειακή απεικόνιση των αγγείων κάτωθεν του βουβωνικού συνδέσμου με Οπτική Συνεκτική Τομογραφία (Optical Coherence Tomography)

    Παρασκευόπουλος, Ιωάννης2014

    … της υπερπλασίας του νέου εσωτερικού χιτώνα (neointima) εντός του stent, η επαναστένωση εντός του stent (ISR) και η κακή εναπόθεση (malapposition) των stent struts σε μια σειρά από ασθενείς που πάσχουν από περιφερική αρτηριοπάθεια (PAD). Μελετήθηκαν, με ποσοτική ανάλυση του αυλού τους …

    patras-thes Repository record

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