Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 120 for “"Neocortex."”.
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Charakterisierung präsynaptischer Nicotinrezeptoren im Neocortex von Ratte und Mensch
… auf noradrenergen und cholinergen Neuronen im Neocortex von Mensch und Ratte, sowie am Hippocampus der Ratte. Als Methode wurde die durch Stimulation mit nicotinischen Agonisten evozierte Freisetzung von [³H]-Noradrenalin (NA) bzw. [³H]-Cholin aus Gewebeschnitten eingesetzt. Zur …
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Analysis and functional characterization in embryonic mouse neocortex of a set of human-specific genes expressed in neural progenitor cells of fetal human neocortex
… der beachtlichen Vergrößerung des menschlichen Neocortex innerhalb der letzten 5-7 Millionen Jahre zu finden. Die Identifizierung der dieser Entwicklung zu Grunde liegenden genomischen Veränderungen ist letztlich nicht nur bedeutsam für die Beantwortung der Frage, welche evolutionären …
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Regulation of Neuronal Excitability by Glutamate and Cholecystokinin Rodent Neocortex
… presence of CCK and its receptors in deep layer neocortex, I have examined the actions of CCK on the excitability of deep layer neocortical neurons. CCK produced a robust depolarization in layer VI pyramidal neurons that was associated with an increase in apparent input resistance and persisted …
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Carbachol- and ACPD-Induced Phosphoinositide Responses in the Developing Rat Neocortex
… roles in the development and plasticity of the neocortex. The present study localized PI responses to individual cortical layers in slices of developing rat somatosensory cortex. The acetylcholine agonist carbachol and the glutamate agonist trans-1-amino-1,3-cyclopentanedicarboxylic acid (ACPD) …
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Connecting the dots. The mechanisms of associative memory in hippocampus and neocortex
Contains fulltext : 175719.pdf (Publisher’s version ) (Open Access)
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Präsynaptische Wirkungen von Cholinesterase-Hemmstoffen im Neocortex des Menschen und der Ratte
… Potenzen der Cholinesterasehemmer im Neocortex des Menschen <br>und der Ratte an präsynaptischen Autorezeptoren ab. Dazu ergänzend bestimmten <br>wir auch erstmals im frischen menschlichen Gewebe die Hemmwirkung dieser Stoffe <br>auf die Acetylcholinesterase selbst. Schnitte aus …
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Gli3 regulates the proliferation and differentiation of progenitors in the developing neocortex
… neurons are generated within the embryonic neocortex itself. These cells are formed from apical and basal cortical progenitors in the developing dorsal telencephalon, and in the mouse cortical neurogenesis begins at approximately embryonic day 10.5 (E10.5). Regulation of the differentiation …
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Causal evidence for the behavioral impact of oscillations in neocortex and hippocampus
… types of oscillations,'gamma rhythms in the neocortex (30-80 Hz) and theta rhythms in the hippocampus (4-12 Hz). In both cases, I use light-gated ion channels to manipulate spike activity on a cycle-by-cycle basis in awake, behaving mice. By rhythmically stimulating fast-spiking interneurons …
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The hemo-neural hypothesis : effects of vasodilation on astrocytes in mammalian neocortex
Astrocytes play an important role in regulating neuronal activity and local brain states, in part by serving as intermediaries between neurons and vasculature. We postulate that neurons and astrocytes are sensitive to biophysical conditions in their local environment, in addition to their …
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Transcriptional Regulation of Neuronal Fate Specification by Proneural Genes in the Developing Neocortex
The neocortex is a relatively recently evolved region of the mammalian central nervous system (CNS) that is involved in the processing of sensory information, motor control, coordination, language, and spatial reasoning. Performing these complex functions requires the coordinated activities of a …
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The Apical Polarity Complex Protein, Pals1, Regulates Cell Fate In The Development of Cerebellum and Neocortex
… signals, and cell types make the cerebellum and neocortex excellent models to address the critical function of polarity complex proteins in the generation and organization of neural tissues. Here we report a focal distribution of Pals1, a central component of the apical complex, in progenitors. …
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Identifiying Casc15 as a novel regulator of progenitors’ proliferation and neuronal migration in the developing neocortex
Ein sehr organisiertes vielschichtiges Gewebe im Gehirn von Säugetieren ist der Neokortex, der höhere kognitive Funktionen ausübt wie Erlernen einer Sprache, Denken und räumliches Vorstellungsvermögen. Während der Evolution hat sich der Neokortex vergrößert, um den komplexen kognitiven Bedarf von …
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Cell Type Specific Roles of Serotonin Receptor 4 in the Hippocampus and Neocortex in Emotion and Cognition
… defined cell types of the hippocampus and neocortex, two regions highly implicated in emotive and cognitive function, I generated a novel Cre-dependent Htr4 knockout mouse line. Intriguingly, the loss of functional 5-HT<sub>4</sub>R specifically in the mature excitatory neurons of the …
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Interneuron networks and cortical dynamics : emulated whisking drives SOM interneurons in the ketamine anesthetized mouse SI neocortex
In the core of this thesis I test and confirm the hypothesis that separate classes of interneurons respond differentially to sensory stimulation independent of volitional or other top-down control on the part of the animal. I also test and confirm the hypothesis that, based only on bottom-up …
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Hippocampal output to neocortex: Examination of the electrophysiological and plastic properties of CA1 projections to the perirhinal cortex
… long-term storage is believed to occur in the neocortex and the physiological mechanism underpinning this transfer of information is believed to be long-term changes in synaptic plasticity, namely long-term potentiation (LTP) and depression (LTD). The aim of this thesis is to characterise …
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Understanding the nervous system as an information processing machine: dense, nonspecific, canonical microcircuit architecture of inhibition in neocortex . . .
This thesis is the combination of two separate lines of work linked by one common goal: understanding the nervous system as an information-processing machine. David Marr (1982) put forth the idea that in order to fully understand an information-processing machine one must understand it at three …
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