Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Neoantigens"”.
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Development of a Neoepitope Prioritization Platform to Identify Immunogenic Neoantigens from Oncogenic FGFR3-TACC3 Fusion in Glioblastoma
… prioritization, and validation of immunogenic neoantigens derived from chimeric RNAs. The FGFR3-TACC3 fusion, generated through an intrachromosomal rearrangement on chromosome 4, produces a unique junctional sequence that constitutively activates oncogenic signaling while remaining absent in …
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The impact of intratumor heterogeneity on anti-tumor immunity
… recognition is bestowed by the presence of neoantigens, derived from mutated sequences arising during tumorigenesis. They are attractive targets because they are specific to tumor cells and have not been subjected to central immune tolerance mechanisms. However, there is mounting evidence …
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Defining The Cooperation Between Mhc-I and Mhc-Ii Neoantigen-Driven T Cell Responses to Develop Effective Personalized Immunotherapies
… somatic alterations that can function as tumor neoantigens. We used a poorly immunogenic <em>Braf<sup>v600e</sup> Pten<sup>-/- </sup>Cdkn2a<sup>-/-</sup></em> YUMM1.7 (Y1.7) murine melanoma line with a paucity of endogenous neoantigens that is unresponsive to ICT, and introduced model …
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Interrogation of Changes in Cell State during Tumor Evolution of a Genetically Engineered Mouse Model of Lung Adenocarcinoma
… recognize experimentally defined tumor neoantigens and provide evidence for an antigen dominance hierarchy that creates competition between T cell responses to tumor neoantigens. Critically, we find that this hierarchy influences the functionality of CD8 T cells and describe novel …
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Intron Retention Induced Neoantigen as Biomarkers in Diseases
… RNA transcripts can be another major source of neoantigens directly associated with immune responses. Particularly, aberrant peptides derived from unspliced introns can be presented by the major histocompatibility complex (MHC) class I molecules on the cell surface and elicit immunogenicity. In …
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From Oncogenesis to Immunotherapy: Mathematical Modeling of Heterogeneous Cancers
… to simulate the acquisition of tumor-specific neoantigens in MMR-D CRC. By using these in-silico tumors as initial conditions in a dynamical systems model of tumor-immune interactions, parameterized using clinical trial data, we characterize features associated with a durable response to immune …
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Engineered Anti-CD40 Agonist Antibody for Cancer Vaccine Delivery
Cancer vaccines targeting patient-derived neoantigens offer great promise for personalized cancer therapy but face challenges in achieving targeted delivery to antigen-presenting cells (APCs) to elicit robust and durable cancer-specific immune responses. We synthesized an anti-mouse CD40 …
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Deciphering the heterogeneity and spatial architecture of tumors
… exome by performing a depletion analysis on neoantigens.
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The effects of aging and transformation on the DNA, RNA, protein, and hydroxyproline content of fibroblasts (WI 38) in culture
… as the cells of an organism age forming neoantigens and functioning in the autoimmune reactions; the Cross-linkage theory which maintains that large molecules necessary for life processes, such as deoxyribonucleic acid (DNA) and collagen are progressively immobilized in all cells and …
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Integrative genomic approaches to dissecting host-tumor and host-pathogen immune processes
… The number of predicted MHC Class I-associated neoantigens was correlated with cytolytic activity and was lower than expected in colorectal and other tumors, suggesting immune-mediated elimination. We identified recurrently mutated genes that showed positive association with cytolytic activity, …
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Complex N-Glycosylation in Anti-Tumor Immunity
… glycosylated proteins may function as tumor neoantigens. The glycosyltransferase Mgat5 catalyzes the formation of 1,6-N-acetylglucosamine branched glycans, and overexpression has been implicated in tumor growth and metastasis in multiple cancers. Using a panel of clonal cell lines that …
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Discovery of Immunogenic Neo-peptides from Actionable RNA Fusion CD74-NRG1 for Developing Cancer Vaccines
… for identifying and validating immunogenic neoantigens from chimeric RNAs, with promising implications for personalized cancer vaccines. The CD74-NRG1 fusion, resulting from a translocation between chromosomes 5 and 8, creates a unique fusion junction that disrupts cell signaling and drives …
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Investigation of T cell-mediated immune surveillance against tumor-specific antigens in genetically engineered mouse models of cancer
… to introduce exogenous antigens, to mimic neoantigens, into genetically engineered mouse models of lung cancer and sarcomas. Utilizing the mouse model of lung cancer, I show that endogenous T cells respond to and infiltrate lung tumors, delaying malignant progression. Despite continued …
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Discovery of Immunogenic Neopeptides from Chimeric RNAs to Develop Peptide and mRNA Vaccines for Lung Cancer Treatment
… tumor samples, extract and validate immunogenic neoantigens from fusion junctions, and design vaccines for the treatment of cancer.
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Mismatch Repair Deficient Neoantigen and Associated Circulating T-Cell Receptor Repertoires in Lynch Syndrome
… develop MMRd tumors with high loads of shared neoantigens (neoAgs), which are recognized by the immune system. Previous research has concentrated on discovering neoAgs and their potential as targets for vaccines in LS patients. However, these studies have primarily identified shared neoAgs from …
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Characterising the evolutionary dynamics of hypermutated tumours using single-cell sequencing
… hypermutation, which leads to a high burden of neoantigens and increased tumour immunogenicity. As a result, hypermutated cancers show the highest response rates to immune checkpoint blockade (ICB), a type of immunotherapy that has revolutionised the treatment landscape for multiple cancer …
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Quantitative dynamics of T-cell receptor repertoires and their use for cancer patient stratification
… is also evidence that TCRs that recognise cancer neoantigens undergo clonal expansion in peripheral blood and can be found at detectable clone frequencies. In this work, we explore the uses of quantitative analyses of longitudinal TCR repertoire samples in health and cancer to understand the …
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Mechanisms driving the expansion and progression of splicing factor-mutant clonal haematopoiesis
… level. This approach could be used to identify neoantigens specific to SF3B1-mutant cells that could be targeted through immunotherapy. Next, we evaluated the differential expression of proteins in SF3B1-mutant cells. This revealed a striking dysregulation of metabolic proteins which, alongside …
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NOVEL RNA-BASED CANCER VACCINE FOR AML IMMUNOTHERAPY
Acute Myeloid Leukemia is a rapidly progressing malignancy. We hypothesize that personalized mRNA cancer vaccine can be a viable treatment strategy for AML patients. Using mouse AML cell lines, we have found candidate neoepitopes within intron polyadenylation sites, retained-intron sites, and …
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