Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Neoantigen"”.
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Intron Retention Induced Neoantigen as Biomarkers in Diseases
… RNA transcripts can be another major source of neoantigens directly associated with immune responses. Particularly, aberrant peptides derived from unspliced introns can be presented by the major histocompatibility complex (MHC) class I molecules on the cell surface and elicit immunogenicity. In …
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Mismatch Repair Deficient Neoantigen and Associated Circulating T-Cell Receptor Repertoires in Lynch Syndrome
… develop MMRd tumors with high loads of shared neoantigens (neoAgs), which are recognized by the immune system. Previous research has concentrated on discovering neoAgs and their potential as targets for vaccines in LS patients. However, these studies have primarily identified shared neoAgs from …
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Defining The Cooperation Between Mhc-I and Mhc-Ii Neoantigen-Driven T Cell Responses to Develop Effective Personalized Immunotherapies
… somatic alterations that can function as tumor neoantigens. We used a poorly immunogenic <em>Braf<sup>v600e</sup> Pten<sup>-/- </sup>Cdkn2a<sup>-/-</sup></em> YUMM1.7 (Y1.7) murine melanoma line with a paucity of endogenous neoantigens that is unresponsive to ICT, and introduced model …
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The impact of intratumor heterogeneity on anti-tumor immunity
… recognition is bestowed by the presence of neoantigens, derived from mutated sequences arising during tumorigenesis. They are attractive targets because they are specific to tumor cells and have not been subjected to central immune tolerance mechanisms. However, there is mounting evidence …
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Engineered Anti-CD40 Agonist Antibody for Cancer Vaccine Delivery
Cancer vaccines targeting patient-derived neoantigens offer great promise for personalized cancer therapy but face challenges in achieving targeted delivery to antigen-presenting cells (APCs) to elicit robust and durable cancer-specific immune responses. We synthesized an anti-mouse CD40 …
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Genomic and Transcriptomic Landscape of Colorectal Premalignancy
… profiling and assessment of mutation and neoantigen rate of 28 premalignant lesions with DNA mismatch repair (MMR) deficient and proficient background using RNAseq. My results showed an activated immune profile despite low mutational and neoantigen rate, which challenges the canonical view …
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DISSECTING RESISTANCE TO IMMUNOTHERAPY IN MSS COLORECTAL CANCER
… While the high mutational burden and elevated neoantigen levels in MSI CRCs are recognized as key determinants of ICI sensitivity, our study delves into additional factors influencing the unresponsiveness of MSS CRCs to immune checkpoint blockade. To dissect these characteristics, we developed …
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Transglutaminase and peptidylarginine deiminase in the pathogenesis of autoimmune diseases
… and its modified substrate constitutes the neoantigen in autoimmune diseases. However, this hypothesis is challenged by findings in cases of primary Sjögren’s syndrome (pSS), who do not express ACPA, but who have been reported to carry anti-PAD. Objectives: Reproducing the study claiming the …
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Discovery of Immunogenic Neo-peptides from Actionable RNA Fusion CD74-NRG1 for Developing Cancer Vaccines
… the CD74-NRG1 fusion protein as a tumor-specific neoantigen source and presents a comprehensive pipeline for identifying and validating immunogenic neoantigens from chimeric RNAs, with promising implications for personalized cancer vaccines. The CD74-NRG1 fusion, resulting from a translocation …
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Quantitative dynamics of T-cell receptor repertoires and their use for cancer patient stratification
… is also evidence that TCRs that recognise cancer neoantigens undergo clonal expansion in peripheral blood and can be found at detectable clone frequencies. In this work, we explore the uses of quantitative analyses of longitudinal TCR repertoire samples in health and cancer to understand the …
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Development of a Neoepitope Prioritization Platform to Identify Immunogenic Neoantigens from Oncogenic FGFR3-TACC3 Fusion in Glioblastoma
… the FGFR3-TACC3 fusion as a tumor-specific neoantigen source and establishes an end-to-end computational and experimental framework for the identification, prioritization, and validation of immunogenic neoantigens derived from chimeric RNAs. The FGFR3-TACC3 fusion, generated through an …
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Using Tumour Evolution to Understand the Epigenetic and Transcriptional Adaptations of Cancer to Host Immunity
… work on immunoediting has largely focussed on neoantigen loss, but this thesis aimed to expand the immunoediting paradigm to incorporate transcriptomic and epigenetic changes in tumour cells. This thesis describes the epigenetic and transcriptomic characterisation of carcinogen-induced …
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Investigation of The Functional Impact of Anti-Pd-1 On Tumor-Infiltrating Lymphocytes (Til) and Mapping of Tumor Genomic Features Relevant For Response to Til Therapy
… and transcriptomics, whereby we observed neoantigen load significantly correlates with overall survival (OS) and identify particularly the gene <em>ELFN1</em> associated with unfavorable outcome to therapy. Through this research, we hope to further provide insight to understanding TIL and …
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Immunotherapy for murine glioma
… including vaccination with GARC-1 peptide (a neoantigen for GL261), rapamycin, celecoxib, and adoptive T cell therapy. We found that vvDD-IL15Ra-YFP and vMyx-IL15Ra-tdTr each infected and killed GL261 cells in vitro. In vivo, NK cells and CD8+ T cells were increased in the tumor due to the …
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The clonal architecture and tumour microenvironment of breast cancers are shaped by neoadjuvant chemotherapy
… copy number alterations, mutational genotypes, neoantigen load, HLA genotypes and intra-tumoural heterogeneity with chemosensitivity. Possible mechanisms of chemoresistance included LOH at the MHC Class I locus, decreased expression of MHC Class I and II genes and drug influx molecules, as well …
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Dissecting the genomic and epigenomic alterations underlying glioblastoma
… despite the relatively high SSM- and SV-derived neoantigen burdens, ecDNA+ samples exhibited higher transcriptional immune suppression compared to ecDNA- samples, an effect not seen in other complex SV types, suggesting that ecDNAs may modulate the tumour-immune microenvironment to evade immune …
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Ex vivo Charakterisierung von humanen Autoantigen-spezifischen CD4+ T-Zellen mit Fokus auf Multiple Sklerose
… Zell-Population. Diese Assoziation war auch für Neoantigen-spezifische T-Zellen ersichtlich. Diese Tatsache spricht gegen eine Autoantigen-induzierte klonale Expansion von Memory T Zellen und weist auf eine initiale Aktivierung durch ein mögliches Fremdantigen hin. In dieser Hinsicht konnte …
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ROLE OF IL-10 PRODUCING EOMES+ TR1-LIKE CELLS IN MELANOMA
… EOMES+ Tr1-like cells were specific for the neoantigen Ovalbumin (OVA). Single-cell RNA sequencing of purified OVA- specific CD4+ T cells revealed two major clusters: FOXP3+ Tregs and FOXP3- CD4+T-cells containing a Tr1-like population expressing granzyme K (GzmK). Performing a Differential …
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