Global ETD Search
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Showing 1 to 20 of 20 for “"Neoadjuvant therapy"”.
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Artificial intelligence in monitoring response to neoadjuvant therapy for breast cancer
Contains fulltext : 329216.pdf (Publisher’s version ) (Closed access)
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Corrélation of Plasma Osteopontin Levels and 3D US Imaging with Tumor Response to Neoadjuvant Therapy
… of 30-42%. The current standard of treatment is neoadjuvant therapy; however there is a limited ability to monitor tumor response to this treatment. This study looks at two innovative approaches to monitoring tumor response: measurement of plasma osteopontin (OPN) levels and three dimensional …
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The Performance of Circulating Biomarkers in the Prediction of Response to Neoadjuvant Therapy in Patients with Oesophago-gastric Cancer
… beyond 5 years after diagnosis. The addition of neoadjuvant therapy has been shown to increase survival in patients suitable for curative surgery. However, the additional gains are modest and the majority of patients do not respond sufficiently from therapy to gain any benefit. There is an urgent …
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Imaging Markers for Staging of Rectal Carcinoma and Restaging after Neoadjuvant Therapy // Образни маркери при стадиране на ректален карцином и рестадиране след неоадювантна терапия
Предоперативното стадиране и проследяването на ректалния рак е от изключителна важност в модерната онкология. Ролята на образната диагностика е ключова. Целта на тази дисертация е да определи образните биомаркери за туморен отговор и регресия преди и след неоадювантна терапия. Образната диагностика …
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Phenotypic dynamics of rectal cancer under neoadjuvant therapy: a multi-omic single-cell perspective from patient-derived organoids [Evoluzione fenotipica del carcinoma del retto durante terapia neoadiuvante: una prospettiva multi-omica a singola cellula da organoidi derivati dal paziente]
Questo studio esplora i meccanismi di adattamento fenotipico e l’eterogeneità intratumorale (ITH) nel carcinoma colorettale, con particolare attenzione alle forme localmente avanzate di carcinoma del retto. La resistenza terapeutica rappresenta una delle principali sfide in oncologia; comprenderne …
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Localized and disease-selective drug delivery using adhesive hydrogels for treatment of locally advanced TNBC
… such as tamoxifen or Herceptin. Systemic neoadjuvant therapy has been established as the preferred therapeutic approach for locally advanced breast cancer, downstaging the disease and preventing mastectomy. However, complications of systemic chemotherapy are devastating. Local therapy …
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Applying multi-omics to detect indolent and aggressive early-stage lung adenocarcinoma
… decisions in early-stage LUAD. This may include neoadjuvant therapy and more tailored surgical interventions.
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Trends in Receipt and Timing of Multimodality Therapy in Early-Stage Pancreatic Cancer
… at presentation. Therefore, multimodality therapy with surgical resection and chemotherapy is the standard of care for locoregional disease. We described treatment patterns and time trends with regard to age and treatment center in the receipt of multimodality therapy. Methods We used the …
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Trends in Receipt and Timing of Multimodality Therapy in Early-Stage Pancreatic Cancer
… at presentation. Therefore, multimodality therapy with surgical resection and chemotherapy is the standard of care for locoregional disease. We described treatment patterns and time trends with regard to age and treatment center in the receipt of multimodality therapy. Methods We used the …
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Pathologic Markers of Prognosis In Ampullary Carcinoma
… of localized disease. The benefit of adjuvant therapy, however, remains unknown in these patients partly because of difficulty in stratifying which patients are at high risk for recurrence. To better identify those patients who may benefit from adjuvant therapy, I conducted a retrospective …
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Trends in Receipt and Timing of Multimodality Therapy in Early Stage Pancreatic
… at presentation. Therefore, multimodality therapy with surgical resection and chemotherapy is the standard of care for locoregional disease. We described treatment patterns and time trends with regards to age and treatment center in the receipt of multimodality therapy. METHODS: We used the …
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MULTI-OMIC LINEAGE TRACING PREDICTS THE MOLECULAR DRIVERS OF CANCER STEM CELLS IN TRIPLENEGATIVE BREAST CANCER EVOLUTION.
… and patients still rely primarily on chemo-neoadjuvant therapy (NACT). Their poor prognosis is largely driven by extensive phenotypic heterogeneity, sustained by complex genetic and epigenetic interactions that are difficult to dissect without perturbing the native cellular context in which …
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Genexpressionsanalysen zur Charakterisierung primärer Mammatumoren im neoadjuvanten Setting
… for the prognosis of disease outcome and therapy response. In this study primary mamma carcinomas from patients treated with neoadjuvant therapy were analysed. Correlations between gene expression profiles and clinical parameters (tumour- and patient-associated) were detected using a …
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The identification of biomarkers of chemotherapy resistance in breast cancer using comparative proteomics
Background:Chemotherapy resistance is a major obstacle in effective neoadjuvant treatment for locally advanced breast cancer. The ability to predict tumour response would allow chemotherapy administration to be directed towards only those patients who would benefit, thus maximising treatment …
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Joint Network Modeling of Omics Data for Understanding Complex Diseases
… II clinical trial investigating the effect of neoadjuvant therapy in breast carcinomas, I identify potential mechanisms for disease progression and treatment response. In summary, throughout this thesis I develop a range of statistical techniques to study biological networks derived from omics …
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Deep Learning and Radiomics Based Outcome Prediction for Cancer Patients
… for locoregional recurrence (LRR) before radiotherapy using clinical data and PET/CT imaging. In addition, we developed a DL segmentation model to guide the extraction of radiomics features for HNC recurrence-free survival (RFS) prediction using data collected pre-treatment. These approaches …
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Predictive factors of stable or progressive disease during anthracycline with/without taxane-based neoadjuvant chemotherapy in breast cancer
Purpose: Neoadjuvant chemotherapy (NAC) has been shown to effectively downstage locally advanced breast cancer; however, clinically, no response or a progression of the tumor can occur in some cases. Predictive factors of no response or progression are unknown compared to predictive factors of a …
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Body mass index and response to neoadjuvant chemotherapy in Korean breast cancer
BACKGROUND AND OBJECTIVES: The relationship of neoadjuvant chemotherapy(NAC) and body mass index (BMI) in patients with breast cancer have been reported in many studies. According to many studies, poor prognosis is associated with obesity in western breast cancer patients, but not in oriental …
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Analyzing the Effect of Neoadjuvant Stereotactic Ablative Body Radiotherapy on Pancreatic Tumour Perfusion Using Computed Tomography Perfusion
… tumour conditions for better surgical outcome, neoadjuvant chemotherapy is typically administered for BRPC patients. Unfortunately, due to the presence of a desmoplastic stroma, PDAC characteristically has a high tumour density, which can significantly limit tumour perfusion and restrict the …
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Course of clinical response during primary systemic therapy with a dose-dense 4 cycles regime of adriamycin and docetaxel in patients with operable cancer of the breast
Background: <br>In contrast to adjuvant chemotherapy (AST), primary systemic therapy (PST) allows the observation of clinical response under treatment, serving as an in-vivo chemosensitivity test. One possibility to assess tumor response is the consideration and analysis of clinical parameters such …