Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"Neisseria gonorrhoeae"”.
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The Interaction of Neisseria Gonorrhoeae with Human Monocytes
… are capable of phagocytizing and killing N. gonorrhoeae, and that the mechanism of bactericidal activity is not solely dependent on oxidative metabolism.
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Soluble peptidoglycan fragments released by Neisseria Gonorrhoeae suppress appetite
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Monoclonal antibodies against Neisseria Gonorrhoeae: serotyping and diagnostic applications
… method for the non -cultural detection of N. gonorrhoeae; and (iii) to produce monoclonal antibodies directed against gonococcal beta- lactamase and to examine their value in a non - cultural diagnostic test for penicillinase- producing gonococci.
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Investigating antimicrobial resistance mechanisms in Neisseria gonorrhoeae using peptide probes
… evolution of antibiotic resistance strains of Neisseria gonorrhoeae coupled with the paucity of new antimicrobial agents makes the treatment of gonococcal infections challenging. A major cause of resistance is the expression of a multidrug efflux pump termed MtrCDE, which exports a wide range …
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Structural and biochemical investigations into the Neisseria gonorrhoeae ribonucleotide reductase
… the ribonucleotide reductase enzyme from Neisseria gonorrhoeae, the causative agent of gonorrhea. N. gonorrhoeae is a prevalent public health concern presenting a current and imminent risk for multi- and fully-drug resistant strains. Here, we biochemically characterize and present an …
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Transferrin binding protein B structure, function, and export in Neisseria gonorrhoeae
… proteins, such as lactoferrin and transferrin. Neisseria gonorrhoeae utilizes transferrin as an iron source and its iron acquisition system is composed of two transferrin binding proteins: TbpA and TbpB. TbpA is a TonB-dependent, outer membrane transporter and TbpB is a bilobed, surface exposed …
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Molecular characterization of the cell division gene ftsZ in Neisseria gonorrhoeae.
… in all bacteria, although in some organisms like Neisseria gonorrhoeae relatively little is known about cell division. The process has been well characterized in Escherichia coli, with the identification and characterization of many cell division genes. The ftsZ gene is essential in E. coli as the …
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Characterization of an outer membrane protein: macromolecular complex of Neisseria gonorrhoeae
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Investigating FDA-Approved Drugs for Treatment of Multidrug-Resistant Neisseria gonorrhoeae
Neisseria gonorrhoeae, the causative agent of gonorrhea, is the second most prevalent sexually transmitted infection that leads to substantial morbidity and economic burden worldwide. Improperly treated or untreated gonorrhea can lead to severe and life-threatening complications, including …
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Mechanisms of Iron Acquisition Employed by Neisseria Gonorrhoeae for Survival within Cervical Epithelial Cells
Neisseria gonowhoeae has evolved a repertoire of high-affinity iron acquisition systems to facilitate essential iron uptake in the human host. Acquisition of iron requires both the energy-harnessing cytoplasmic membrane protein, TonB, as well as specific outer membrane TonB-dependent transporters …
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Exploring a Novel Anti-Gonococcal Compound for Combating Drug-Resistant <i>Neisseria gonorrhoeae</i>
The Gram-negative bacterium Neisseria gonorrhoeae, the causative agent of gonorrhea, is a significant public health concern due to its rapid development of resistance to antibiotics, leading to limited treatment options and potentially untreatable infections. This pathogen primarily infects the …
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Functional characterization of the cell division protein MinE from the Gram-negative coccus Neisseria gonorrhoeae
… bacillus Escherichia coli (Ec), and the coccus Neisseria gonorrhoeae (Ng). The Min proteins are important to properly initiate cell division in bacteria at the midcell. Previously, it had been considered that Min proteins were implicated in midcell site selection in only rod-shaped bacteria. Our …
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Characterisation of the ATP-dependent ligase, Lig E: An investigation into its significance in Neisseria gonorrhoeae
The rapid rise in multidrug-resistant Neisseria gonorrhoeae isolates has caused major public concern for the treatment of its sexually transmitted disease, gonorrhoea. Previously easily treatable, gonorrhoea is now spreading at alarming rates due to the bacterium’s ability to take up DNA from its …
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Genetic and molecular characterization of origins of replication from beta-lactamase-producing plasmids of Neisseria gonorrhoeae.
This work represents a comprehensive analysis of the precise structural relationship and organization existing amongst the gonococcal beta-lactamase-producing plasmids. The second major aspect of this work deals with investigations into the genetic and molecular characterization of the multiple …
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The Role of the ITAM-containing CEACAM3 Receptor in the Neutrophil Response to Infection by Neisseria gonorrhoeae
Bacterial species of the genus Neisseria include pathogens that are responsible for diseases of humans including bacterial meningitis (Neisseria meningitidis) and the sexually transmitted disease gonorrhea (Neisseria gonorrhoeae). These diseases are often characterized by a massive influx and …
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Desarrollo de una sonda de ADN de origen plasmídico para la identificación y detección de neisseria gonorrhoeae
Neisseria gonorrhoeae, es el agente causal de la gonococia, enfermedad de transmisión sexual reconocida como una de las causas principales de morbilidad en muchas zonas del mundo (Donegan, 1985). La gonococia es a menudo recurrente y ocasionalmente produce complicaciones, como la enfermedad …
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Mathematical modelling of the population impact of screening for Chlamydia Trachomatis and Neisseria gonorrhoeae in South Africa
… and prevalence of Chlamydia trachomatis and Neisseria gonorrhea in South Africa. We extended an existing agent-based model of heterosexual HIV and STI transmission in South Africa to investigate the impact of targeted screening strategies directed at high risk groups including youth, female …
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Epidemiología de la infección por Neisseria gonorrhoeae en Asturias. Caracterización de las cepas circulantes y estudio de resistencias
… enfermedad de transmisión sexual producida por Neisseria gonorrhoeae. Desde 2001, se ha observado un aumento de estas infecciones. Desde el comienzo de la era antibiótica el gonococo ha ido desarrollando mecanismos de resistencia a los antibióticos empleados en su tratamiento. La emergencia de …
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Maternal Chlamydia trachomatis and Neisseria gonorrhoeae Infections and the Outcome of Preterm Birth: The Impact of Early Detection
… infection with Chlamydia trachomatis and/or Neisseria gonorrhoeae, both high prevalence sexually-transmitted infections, may convey a higher risk of preterm birth. Early detection and treatment of these infections without recurrent/persistent infection during pregnancy may serve as an …
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