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Showing 1 to 20 of 112 for “"Neisseria"”.
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The electron transport chains of Neisseria meningitidis
Neisseria meningitidis contains c-type and b-type cytochromes. Oxidation of c-type and b-type cytochromes by oxygen was observed in both cells grown under aerobic and denitrifying conditions, whereas oxidation of cytochromes by nitrite was only seen in cells grown under denitrifying conditions, and …
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The Interaction of Neisseria Gonorrhoeae with Human Monocytes
The ability of human monocytes to phagocytize and kill nonpiliated opaque (T3) and transparent (T4) gonococci was investigated in a tumbling tube suspension assay. A serum-sensitive strain, F62, and a serum-resistant strain, FA19, were studied. Viable colony-forming units remaining after incubation …
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Analyse des Hitzeschocks bei Neisseria meningitidis mit DNA-Microarrays
Das Gram negative Bakterium Neisseria meningitidis ist weltweit ein bedeutender Erreger der bakteriellen Meningitis. Obwohl das ausschließlich humanpathogene Bakterium in bis zu 25% der Europäischen Bevölkerung die oberen Atemwege als harmloser Kommensale besiedelt, kommt es unter bestimmten, noch …
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Soluble peptidoglycan fragments released by Neisseria Gonorrhoeae suppress appetite
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Monoclonal antibodies against Neisseria Gonorrhoeae: serotyping and diagnostic applications
The aims of this study were (i) to investigate the value of newly developed monoclonal antibody coagglutination reagents for serotyping gonococci according to Protein I variation between strains; (ii) to determine if these or similar monoclonal antibodies could be used in an immunological method …
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Typing and genome comparison of Neisseria meningitidis by DNA-microarrays
… technology for molecular epidemiology of Neisseria meningitidis have been followed. The first one evaluated microarrays based on polymorphism-directed oligonucleotide design for typing of N. meningitidis adopting the multilocus sequence typing (MLST) concept. The number of oligonucleotides …
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Investigating antimicrobial resistance mechanisms in Neisseria gonorrhoeae using peptide probes
… evolution of antibiotic resistance strains of Neisseria gonorrhoeae coupled with the paucity of new antimicrobial agents makes the treatment of gonococcal infections challenging. A major cause of resistance is the expression of a multidrug efflux pump termed MtrCDE, which exports a wide range …
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Structural and biochemical investigations into the Neisseria gonorrhoeae ribonucleotide reductase
… the ribonucleotide reductase enzyme from Neisseria gonorrhoeae, the causative agent of gonorrhea. N. gonorrhoeae is a prevalent public health concern presenting a current and imminent risk for multi- and fully-drug resistant strains. Here, we biochemically characterize and present an …
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Analyse des Transkriptoms von Neisseria meningitidis Serogruppe B mit DNA-Microarrays
Die Anwendbarkeit eines Oligonukleotid-basierten Microarray-Systems zur Transkriptomanalyse von Neisserie meningitidis Serogruppe B wurde im Vergleich mit einem cDNA-basierten System demonstriert. Hierzu wurde für ein Subset von 60 Genen die Eigenschaften anhand von Parallelhybridisierungen sowie …
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Identifizierung und Charakterisierung von Plasmiden verschiedener klonaler Gruppierungen in Neisseria meningitidis
128 Meningokokkenstämme unterschiedlicher klonaler Linien und Serogruppen aus verschiedenen Ländern wurden im Rahmen eines Screenings auf die Präsenz von Plasmiden untersucht. Aus 66% der Stämme konnten Plasmide isoliert werden. Diese waren innerhalb der verschiedenen klonalen Linien spezifisch …
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Transferrin binding protein B structure, function, and export in Neisseria gonorrhoeae
… proteins, such as lactoferrin and transferrin. Neisseria gonorrhoeae utilizes transferrin as an iron source and its iron acquisition system is composed of two transferrin binding proteins: TbpA and TbpB. TbpA is a TonB-dependent, outer membrane transporter and TbpB is a bilobed, surface exposed …
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Molecular characterization of the cell division gene ftsZ in Neisseria gonorrhoeae.
… in all bacteria, although in some organisms like Neisseria gonorrhoeae relatively little is known about cell division. The process has been well characterized in Escherichia coli, with the identification and characterization of many cell division genes. The ftsZ gene is essential in E. coli as the …
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Characterization of an outer membrane protein: macromolecular complex of Neisseria gonorrhoeae
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Investigating FDA-Approved Drugs for Treatment of Multidrug-Resistant Neisseria gonorrhoeae
Neisseria gonorrhoeae, the causative agent of gonorrhea, is the second most prevalent sexually transmitted infection that leads to substantial morbidity and economic burden worldwide. Improperly treated or untreated gonorrhea can lead to severe and life-threatening complications, including …
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Genetische Diversität der humanen kommensalen Bakterienart Neisseria lactamica in epidemiologisch verknüpften Gruppen
… Pfarrkirchen, Sonthofen und Weiden insgesamt 287 Neisseria lactamica-Stämme isoliert. 26 ausgewählte, aus den benachbarten Städten Augsburg, Ingolstadt und München stammende Isolate wurden einer Multi-Lokus-Sequenztypisierung (MLST) zur Untersuchung ihrer genetischen Diversität unterzogen. Dabei …
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Interaktion von Neisseria meningitidis mit den Zellen der menschlichen Blut-Hirn/Liquor-Schranke
… in der Pathogenese einer bakteriellen, durch Neisseria menigitidis verursachten Meningitis stellt die Interaktion der Bakterien mit den Zellen der menschlichen Blut-Hirn/Liquor-Schranke dar. In der vorliegenden Arbeit konnten in Infektionsversuchen mit immortalisierten HBMEC-Zellen als …
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Herstellung eines monoklonalen Antikörpers gegen die Endonuklease NmeDI zur Typisierung von Neisseria meningitidis
Neisseria meningitidis ist eine der führenden Ursachen von Morbidität und Mortalität sowohl bei Kindern als auch bei Erwachsenen. Die Typisierung ist die Grundlage für die epidemiologische Überwachung der Erkrankung durch Meningokokken. Die Endonuklease NmeDI ist spezifisch für die klonalen Linien …
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Identification and molecular characterization of a putative heme ABC transporter in Neisseria meningitidis
… detailed mechanism for heme uptake in pathogenic Neisseriae has not yet been elucidated. Once heme is deposited in the periplasmic space, a heme dedicated ABC transporter has been hypothesized to convey heme into the cytoplasm. To address this hypothesis, we used several molecular techniques to …
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Mechanisms of Iron Acquisition Employed by Neisseria Gonorrhoeae for Survival within Cervical Epithelial Cells
Neisseria gonowhoeae has evolved a repertoire of high-affinity iron acquisition systems to facilitate essential iron uptake in the human host. Acquisition of iron requires both the energy-harnessing cytoplasmic membrane protein, TonB, as well as specific outer membrane TonB-dependent transporters …
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