Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Neglected tropical diseases"”.
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Mapping and modeling of neglected tropical diseases in Brazil and Bolivia
… important step in the control and prevention of diseases. This study used geographical information systems and remote sensing technologies within the MaxEnt ecological niche modeling program to create predictive risk maps for leprosy and Schistosomiasis in Brazil and Chagas disease in both Brazil …
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An AI-Based Machine Vision Model for the Diagnosis of Neglected Tropical Diseases
Neglected Tropical Diseases (NTDs) affect more than 1 billion of the world’s population[1], and yet, the area of rapid diagnostics is still in its infancy. Much work has been done on machine learning and integration of AI into the medical workflow with cancer and other diseases but the area of NTDs …
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A health information platform for Case Managed Neglected Tropical Diseases - A case study from Mozambique
Leprosy, as one of the neglected tropical diseases, is an ancient disease that requires a slow and patient approach for its diagnosis and treatment involving various actors along the way. This care system has traditionally been supported by a paper based health information system still in use today …
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If you build it, they will run : the role of clinical trial infrastructure in neglected disease R&D
… on research and development (R&D) levels for neglected tropical diseases concentrated in those countries. Pre-existing clinical trial infrastructure in a location can affect the cost and time of clinical trials carried out there, thus influence returns on investments for diseases that are …
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Modular Synthesis and Hydroalkylation of Vicinally Functionalized Ketopiperazines: A solution to the Piperazine Problem
… structure-activity-relationship (SAR) studies on neglected tropical diseases (NTDs), including leishmaniasis.
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A Nonribosomal Peptide Pheromone Controls Male-Induced Female Sexual Development in Schistosoma mansoni
… causing one of most prevalent and serious neglected tropical diseases. Their immense egg output in the host is the main source of pathology, placing their reproductive biology of great importance for scientific researches. A bizarre, and physiologically meaningful phenomenon of their …
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Structural Characterization of the interaction between divalent cations and the novel Schistosoma mansoni Universal Stress Protein G4LZI3
… every year. This coupled with other severe Neglected Tropical Diseases, HIV/AIDS, malaria, tuberculosis and poverty, does not make the situation any better. Vaccines targeting this disease are still yet to be discovered and current treatment is becoming a problem as drug resistance has been …
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Total Synthesis of the Actinoallolides and a Designed Photoaffinity Probe for Target Identification
… need for new and effective treatments for these neglected tropical diseases, and the high selectivity index of actinoallolide A makes it a promising drug candidate. Enabled by the highly stereocontrolled aldol reactions of three chiral ketone building blocks, an efficient fi rst total synthesis …
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Dengue and development: a critical political ecology
… the dearth of research into the world's neglected tropical diseases (NTDs); in particular, gaps in our understanding of the biopolitical and socioecological contexts (sites of urban governance, sites of health policy development and implementation, and sites of academic research) in which …
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Evolution of vesicular transport in kinetoplastids: dynamics and novel gene products
… parasites are etiological agents of several neglected tropical diseases such as African sleeping sickness, Chagas disease, and Leishmaniasis. Newly available sequences of many kinetoplastid genomes were used to reconstruct evolution of trafficking across this lineage, using three central …
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Use of an 18s rRNA metagenomics approach as a method of detection of multiple infections in field blood samples collected on FTA cards from cattle
… health problems in humans and animals globally. Diseases in tropical and remote areas, sometimes known as neglected tropical diseases, pose some of the greater problems due to the difficulty in collecting and analysing samples. Collecting samples from remote and tropical areas is difficult, …
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Loop-mediated isothermal amplification (LAMP) for the diagnosis of human sleeping sickness: towards a point-of-care diagnostic test
Acute and chronic sleeping sickness are fatal neglected tropical diseases caused by Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense respectively (members of the sub-genus Trypanozoon). Accurate diagnostics are needed to guide treatment since the symptoms of disease are non-specific …
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Characterising the bacterial microbiota of Phlebotomus and Glossina insects : vectors of parasitic diseases
… carry. Trypanosomiasis and leishmaniasis are neglected tropical diseases caused by kinetoplast parasites and transmitted between human hosts by biting flies. In this thesis the bacterial microbiota of tsetse flies and sand flies, the vectors of trypanosomiasis and leishmaniasis respectively, …
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Biophysical characterisation of the interaction between the S.mansoni G4LZI3 protein and the NAD binding domain of glyceraldehyde-3 phosphate dehydrogenase
… the hotspot of global burden where the most neglected tropical diseases are concentrated. Several countries have, however, made considerable progress in control of the schistosomiasis morbidity through mass drug administration of Praziquantel (PZQ) to school-aged children and other high risk …
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Engagement of human host receptors by the antiparasitic drug praziquantel
Neglected tropical diseases (NTDs) impact nearly two billion people worldwide. Schistosomiasis is one of the most debilitating NTDs causing a significant healthcare and economic burden in developing countries. The disease is caused by trematodes of the species Schistosoma and is endemic in 78 …
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Target Identification and Mechanism of Action Studies in Folate Metabolism in Kinetoplastids
… stricken areas of the world are affected by Neglected Tropical Diseases, with an estimated 1 billion sufferers. As well as inadequate living conditions and healthcare, there has been very little pharmaceutical incentive to tackle these diseases. As a result, the diseases are still spreading. …
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Characterisation of novel peptides as candidates for diagnosis of schistosomiasis
… is one of the most prevalent parasitic diseases worldwide: affecting around 250 million people, with 90% of cases occurring in sub-Saharan Africa. Elimination as a public health problem is ambitious given the current lack of sensitive and specific diagnostics. There is urgent need for …
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Novel Applications of Geospatial Analysis in the Modeling of Infectious Diseases
… We theorize that they can also be applied to diseases that spread exclusively by person-to-person contact. Exploring this allows us to find areas of underreporting, as well as areas with unusual local forcing which might merit further investigation by the health department. We also explore …
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Structural Characterization of the Switch domain regions of Schistosoma mansoni druggable Adenylate cyclase-stimulating Gα-protein
Among the neglected tropical diseases (NTDs), schistosomiasis, a common human parasitic disease; continues to rank high as one of the major causes of morbidity and mortality among the labour forces in known endemic regions. Recently, the socio-economic impact of Schistosoma infections have been …
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The Impact of Ivermectin Treatment in Cattle on Dung Degradation and Fauna Abundance and Diversity in Tanzania
… it has been used for the control of several neglected tropical diseases. With regards to efforts to control malaria, mass drug administration (MDA) of ivermectin in humans and livestock has been considered as a potential tool. This is due to challenges in malaria preventive strategies such as …
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