Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 243 for “"Negative regulator"”.
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ATGLR3.7 AS NEGATIVE REGULATOR OF ATGLR3.3 MEDIATED STRESS RESPONSES
… our laboratory indicate that GLR3.7 activity can negatively impact GLR3.3-mediated responses, such as burning and exogenous amino acid administration, suggesting this GLR isoform as a putative partner of GLR3.3. Colocalization and close proximity of GLR3.3 and GLR3.7, both at tissue and cellular …
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Study of Rest As A Negative Regulator of P16Ink4A
<p><strong>STUDY OF REST AS A NEGATIVE REGULATOR OF P16<sup>INK4A</sup></strong><strong> </strong></p> <p><strong>Monica Gireud, B.S.</strong></p> <p><strong>Thesis Advisor: Vidya Gopalakrishnan, Ph.D.</strong></p> <p>The<em> RE1</em> Silencing Transcription Factor (REST) is a negative regulator of …
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RacGap50C Is a Novel Negative Regulator of Wnt Signaling
… genetically with naked cuticle and Axin, known negative regulators of the Wg pathway. These phenotypes suggest that the RacGap50C gene product participates in the negative regulation of Wg pathway activity. </p><p>In addition to the role of RacGap50C in regulating Wg signaling, RacGap50C, with …
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Role of the Plasma Membrane Calcium ATPase as a Negative Regulator of Angiogenesis
… therefore the identification of an endogenous regulator of this pathway would be beneficial. One possibility is the plasma membrane calcium ATPases (PMCAs). These high affinity calcium extrusion pumps have been shown to interact with calcineurin in mammalian cells and cardiomyocytes and …
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Type 1 Interferon: A Negative Regulator Of Myeloid-Derived Suppressor Cells Function In Cancer
… elicited a robust anti-tumor effect. Thus, negative regulatory mechanisms of MDSC function can be exploited therapeutically.
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Characterisation of the AT4G11100 gene, a negative regulator of disease resistance in Arabidopsis thaliana
… defence genes. Evidence suggests that CIR1 is a negative regulator of plant immunity important in the absence of pathogen attack. Genetic mapping experiments indicate that cir1 is located on the lower arm of chromosome 4 of A. thaliana and may be one of 8 known genes in the region. Analysis of …
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Molecular Dissection of Bsc2: A Novel Negative Regulator of Triglyceride Lipolysis for a Lipid Droplet Subpopulation
… subset of TG-containing LDs, and reveal it negatively regulates TG lipolysis. Mechanistically, Bsc2 LD targeting requires TG, and LD targeting is mediated by specific N-terminal hydrophobic regions (HRs) sufficient for Bsc2 function. Molecular dynamics simulations reveal these Bsc2 HRs …
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Genetic Approach to Discover ARMC4 as a Novel NF-κB Negative Regulator and Tumor Suppressor in Colorectal Cancer
… repeat containing protein 4 (ARMC4) as a novel negative regulator of NF-κB in colorectal cancer (CRC). ARMC4 is a rarely studied protein only known to date for its role in primary ciliary dyskinesia (PCD) and mouse spermatogenesis. Thus, my work reveals a completely new facet of ARMC4 function …
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Regulation of nitrogen fixation in <i>Klebsiella pneumoniae</i>: Nitrogen and oxygen signal perception by the negative regulator NifL
In dem diazotrophen Organismus Klebsiella pneumoniae wird der nif - spezifische Transkriptionsaktivator NifA als Reaktion auf molekularen Sauerstoff und Ammonium durch NifL gehemmt. Die Komplexbildung zwischen NifL und NifA (etwa 1:1-Verhältnis) erfolgt, wenn die Synthese der beiden Proteine in …
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CD23's Role as a Negative Regulator of Allergic Disease: in vivo Effects of Murine CD23 Destabilization and Allelic Mutations
… overexpression studies, CD23 has been shown to negatively regulate IgE production. To investigate CD23 destabilization and its effects on CD23 shedding and IgE synthesis in vivo, we utilized an anti-CD23 stalk monoclonal (19G5) which has previously been shown to enhance proteolysis of CD23 in …
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Validation-based insertional mutagenesis (VBIM) technology identifies adenomatous polypossis coli (APC) like protein (ALP) as a novel negative regulator of NF-κB
… coli (APC) like protein (ALP) gene as a negative regulator of NF-κB. Preliminary studies from our lab demonstrated that overexpression of ALP led to decreased NF-κB activity by κB reporter assay and electrophoresis mobility gel shift assay (EMSA). The current project aims to further …
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Development Of Peptide Inhibitors Targeting Clostridium Difficile Toxins A/b And Characterizing The Regulatory Role Of A Putative Negative Regulator Tcdc In Clostridium Difficile Toxin Gene Expression
… of the functional role of a</p> <p>negative regulator (TcdC) involved in toxin gene expression. In this work, we used a</p> <p>variety of biochemical and genetic approaches and characterized TcdC is not repressor</p> <p>instead acts as an Extra Cytoplasmic Class (ECF) anti-sigma …
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The transcriptional programme of natural killer (NK) cell functional maturation and maintenance
… factors (TFs), and multiple positive regulators of this process have been defined. However, mechanisms by which NK cells remain quiescent in tissues are incompletely elucidated. The transcriptional repressor BACH2 plays a critical role within the adaptive immune system but its function …
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Global characterization of the Pho regulon in Caulobacter crescentus
… I use ChIP-Seq on the transcriptional regulator PhoB to globally map the Pho regulon in Caulobacter in both phosphate-starved and -replete conditions. I find that the regulatory regions of over 50 genes are bound by PhoB following phosphate limitation, and I identify a consensus PhoB …
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IL-27 AND THE REGULATION OF INNATE AND ADAPTIVE IMMUNITY DURING TOXOPLASMOSIS
The cytokine IL-27 is a potent negative regulator of the inflammatory response to the pathogen Toxoplasma gondii, and the majority of the studies on IL-27 during this infection have focused on its ability to limit T cell responses. The basis for this suppressive activity is unclear, but it was …
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Studies on the POLARIS gene of Arabidopsis
… Previous work indicates that PLS acts as a negative regulator of ethylene signalling. The pls mutant has enhanced ethylene signalling, which is the key determinant of its short root phenotype and results in a ‘triple response’ phenotype when seedlings are grown in the dark in air. The …
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The identification of the mTOR-regulated phosphoproteome and a mediator of feedback inhibition to P13K-Akt
… profiled. Grbl 0 is an adaptor protein and negative regulator of growth factor signaling identified as an mTORC1 substrate that mediates the inhibition of P13K typical of cells lacking TSC2, a tumor suppressor and negative regulator of mTORC1. Phosphorylation of Grbl 0 is important for its …
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The control of Schwann cell myelination during development and after nerve injury
… have been divided into two groups; positive and negative regulators. Sox10, NFATc4, Oct6, Krox20 and the ERK 1/2 signalling pathway have been characterised as positive regulators of Schwann cell differentiation and myelination; with Sox10 and Krox20 also playing critical roles in myelin …
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Characterization of the effects of regulators PrgY and PrgZ on the inducibility of plasmid pCF10 in Enterococcus faecalis
… production- ccfA, 2) the plasmid-encoded negative regulator prgY thought to be responsible for sequestration of endogenous pheromone at the cell surface, and 3) the plasmid-encoded positive regulator prgZ, an oligopeptide permease subunit A homolog responsible for specific import of …
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The role of BCAP in regulating the TLR signalling pathway
… (B-cell adapter for PI3K) was identified as a negative regulator in the TLR4 MYD88-dependent signalling pathway. This study utilises biochemical, biophysical and structural biological techniques and focuses on two hypotheses to elucidate the role of BCAP in the TLR signalling pathways. The …
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