Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"Negative Selection"”.
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Studies on Real-Valued Negative Selection Algorithms for Self-Nonself Discrimination
… detection, and data mining. The real-valued negative selection algorithm (RNSA) is a computational model of the self/non-self discrimination process performed by the T-cells in natural immune systems. In this research, three different real-valued negative selection algorithms (i.e., the …
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Artificial immune system based on real valued negative selection algorithms for anomaly detection
The Real-Valued Negative Selection Algorithms, which are the focal point of this research, generate their detector sets based on the points of self data. Self data are regarded as the normal behavioral pattern of the monitored system. In this research, the Real-Valued Negative Selection with …
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Structural basis for escaping negative selection by T cell receptor with high affinity for self antigen
… strategy whereby autoreactive T cells escape negative selection, yet retain the ability to initiate autoimmunity.
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An improved negative selection algorithm based on the hybridization of cuckoo search and differential evolution for anomaly detection
… area of computational intelligence. Real-Valued Negative Selection Algorithm with Variable-Sized Detectors (V-Detectors) is an offspring of AIS and demonstrated its potentials in the field of anomaly detection. The V-Detectors algorithm depends greatly on the random detectors generated in …
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A T cell receptor transgenic approach to the study of thymocyte development and autoimmune disease
… such recognition may result in either positive selection, allowing the cell to mature, or negative selection, eliminating that T cell clone from the host's repertoire. The parameters that determine thymocyte fate have remained unclear. An experimental study was carried out to determine these …
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PKB/Akt : a critical regulator of lymphocyte, development and function
… different TCR tg model systems for positive and negative selection of immature precursors in the thymus, we found myr PKB promotes positive selection of CD4+ but not CD8+ T cells. This most likely results from PKB’s positive cross-talk on Lck-Raf-Erk signalling, which is known to influence …
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The scaffold protein POSH regulates T lymphocyte function
… dispensable for JNK activation and positive and negative selection in developing thymocytes. Thus, POSH couples the TCR to JNK activation in a cell type and developmental stage dependent manner. This work also revels a novel target for the treatment of autoimmune disorders such as Type I Diabetes …
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Die Bedeutung des Bcl-2 Familienmitgliedes Bim in der negativen Selektion von B-Zellen
… BCR-Stimulation vermittelten Apoptose und der negativen Selektion von B-Zellen untersucht. Dabei zeigte sich sowohl in vitro als auch in vivo, dass Bim essentiell für die BCR-vermittelte Apoptose ist.
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An investigation to cybersecurity countermeasures for global internet infrastructure.
… as S-BGP and BGPsec as well as the traditional Negative Selection AIS algorithm. The results demonstrate improved precision of detecting attacks for the Hybrid AIS model compared with the Negative Selection AIS. Higher precision was achieved with S-BGP and BGPsec, however, at the cost of higher …
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Structural Damage Assessment Using Artificial Neural Networks and Artificial Immune Systems
… a neural network and an AIS algorithm known as negative selection (NS). The effectiveness of both methods are validated using simulated acceleration data of a four story structure exhibiting various damage states via computer simulation.</p>
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Anomaly based Intrusion Detection System through Remote Virtual Machine Introspection
… by a biological immune system and based on negative selection algorithm approach to detect various types of malwares is proposed in this paper.</p> <p>By deeply studying Linux kernel, understanding links behind different internal system processes, examining, and experimenting with hundreds …
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Stairway to Fairness: The Impact of Explanations on Applicant Reactions to Automated Video Interviews
… have transformed the landscape of organizational selection systems. In order to remain competitive and identify top talent, organizations have increasingly adopted new tools like automated interviews and evaluations to help in the decision-making process (Jaser et al., 2022). One such tool is …
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Deciphering the heterogeneity and spatial architecture of tumors
… clinical studies. Finally, we attempt to detect negative selection in the cancer exome by performing a depletion analysis on neoantigens.
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An experimental investigation into the mechanisms of bacterial evolution
… two different conditions: i) in the absence of selection; ii) in the presence of negative selection pressure — bacteriophage infection. Last, I will investigate spontaneous mutation through qPCR assay of competition between wild-type and mutator phenotype <em>E. coli</em>. Mutator …
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Epigenetic analysis of promiscuous gene expression in central tolerance
The autoimmune regulator (AIRE), a key player in negative selection of developing thymocytes, acts as a transcriptional regulator, inducing the expression of tissue restricted antigens (TRA) within medullary thymic epithelial cells in a process known as promiscuous gene expression (PGE). Here we …
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Dominant Suppression of Early Innate Immune Mechanisms by Yersinia pestis
… pestis</italic> evolution. I also developed a negative selection screen termed transposon site hybridization: TraSH) to identify bacterial factors required for the two different phases of <italic>Y. pestis</italic> pulmonary infection. I validated the technique by defining the essential genes …
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The Major Histocompatibility Complex (MHC) and the proteasome-ubiquitin pathway in T cell development
… numbers of mature CD8+ T cells, indicating that selection of CD8+ T cells can not be compensated for by [beta]2m-associated molecules other than classical H-2K and D locus products. Spleen cells from KbDb -/- mice generate strong CD8+ MHC class I-specific responses after in vivo priming. Thus, a …
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The mechanism of T cell dysfunction induced by Diethylstilbestrol
… that DES exposure altered both positive and negative selection of Tcells. Furthermore, DES was found to alter the ability of T cells to proliferate during animmune response. Finally, we studied the intrathymic interaction between thymicstromal cells and thymic T cells. We found that cel1:cell …
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In vitro selection of aptamers using quantum dot-assisted capillary electrophoresis SELEX
… selectively bind to targets with high affinity. Selection of aptamers is accomplished by the Systematic Evolution of Ligands by EXponential enrichment (SELEX). The target is incubated with a random sequence oligonucleotide library, and target-bound sequences are separated from the unbound pool to …
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On Thymic Regulatory T-Cell Ontogeny
… series of developmental stages, including double-negative (DN), double-positive (DP), and single-positive (SP) stages, leading to the formation of distinct mature T cells. To ensure a diverse and self-tolerant T-cell repertoire capable of effectively responding to a wide range of pathogens while …
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