Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"Negative Regulators"”.
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Beta 3 integrins : negative regulators of angiogenesis
… data suggest a new role for beta 3 integrin as a negative regulator of angiogenesis, both as a receptor for an endogenous inhibitory molecule and as an inhibitor of VEGF-induced angiogenesis.
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Interferon-Inducible GTPases as Positive and Negative Regulators of Inflammasomes
<p>Through the action of pattern recognition receptors (PRRs) the vertebrate immune system is able to detect and respond to invading pathogens. PRRs bind conserved microbial components and subsequently initiate pro-inflammatory defense programs. While effective at eliminating pathogens, these …
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Functional antagonism of the RNA polymerase II holoenzyme by negative regulators
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
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Development of a novel screening platform for identifying genetic pathways regulating axon regeneration
… its DNA. The overall goal is to identify negative regulators in axon regeneration. Here, we performed candidatebased studies to assess novel candidates in neural regulation (Piezo, Atr, Nup188) and developed several novel axon transection microfluidics platforms that cater to various needs …
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Involvement of the WT1 and p16 genes in Wilms' tumour and human malignant mesothelioma
… established and maintained by the positive and negative regulatory activities of many genes. When these genes are mutated to forms that can contribute to tumorigenesis, either by dominant, gain of function mutations in positive regulators or recessive, loss of function mutations in negative …
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Using Translational Switching to Investigate the SCN Clockwork
… delayed feedback loop (TTFL), whereby negative regulators inhibit their own transcription. The positive regulators CLOCK and BMAL drive transcription of the negative regulators Period1/2 and Cryptochrome1/2 via E-BOX regulatory sequences. PER/CRY mediated repression of BMAL/CLOCK closes …
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The Regulation of NAP4 in Saccharomyces cerevisiae
… of Hap4; and (3) identification of two negative regulators of HAP4 expression, CYC8 and SIN4. I also report differential patterns of Hap4 cellular localization which depends on (1) carbon sources, (2) abundance of Hap4 protein, and (3) presence or absence of mitochondrial DNA (mtDNA).</p>
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Regulation of Wnt signalling in ovarian cancer and immune cells
… had previously linked mutations in the negative regulators of the Wnt pathway, Dkk1 and Nkd1, with decreased immune infiltration in ovarian cancers. To interrogate the functional importance of these negative regulators further, I knocked out and expressed Dkk1 and Nkd1 in murine ovarian …
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Mechanisms of TRAF Signaling
… Cbl proteins are identified as positive and negative regulators of Src-family kinase signaling. The molecular structure of TRAF6 is determined and structure-function relationships between TRAF6 and the receptors to which it binds are examined. A physiological role for TRAF1 is identified in …
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A systematic approach for cataloging mTORC1 regulators
… Toward generating a complete list of mTORC1 regulators, we developed a strategy to identify them by CRISPR-Cas9 FACS-based screening. As a proof-of-principle screen, we first identified negative regulators of the mTORC1 pathway. Then, we adapted the technique to uncover positive regulators of …
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Integrative Analysis of the Myc and E2F pathway Reveal the Roles for microRNAs in Cell Fate Control
… miRNAs were contributing to the repression of negative regulators of cell cycle, including PTEN, while in case of E2F pathway, E2F-induced miRs were forming an incoherent Feed-Forward Loop(iFFL) with a number of E2F-induced genes including cyclin E. We further demonstrate through functional …
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Regulation of macrophage subsets in homeostatic and inflammatory mucosal environments
… by ELISA. Cytokines, PRRs and endogenous negative regulatory molecules were detected by RT-PCR and WB and epithelial barrier function was measured by trans epithelial electrical resistance (TEER). ET induced by K12-LPS failed to demonstrate a differential subset-specific response in MΦ …
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The control of Schwann cell myelination during development and after nerve injury
… have been divided into two groups; positive and negative regulators. Sox10, NFATc4, Oct6, Krox20 and the ERK 1/2 signalling pathway have been characterised as positive regulators of Schwann cell differentiation and myelination; with Sox10 and Krox20 also playing critical roles in myelin …
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Identification and functional characterization of RXLR effector proteins that are conserved between downy mildew pathogens and Phytophthora species
… plant species. The targeted PUB proteins are negative regulators of plant immunity in Arabidopsis. These experiments demonstrate that evolutionarily-conserved effectors from different oomycete species can suppress immunity in plant species that are divergent from the source pathogen's primary …
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Sulfatides mediate Disabled-2 membrane localization and stability during platelet aggregation
… flow conditions govern this process. One of the negative regulators in platelet aggregation is Disabled-2 (Dab2), a modular protein that is released upon platelet activation to the extracellular platelet surface.3 Dab2 inhibits platelet aggregation through its phosphotyrosine-binding (PTB) domain …
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Role of the Ajuba LIM Proteins in Epithelial Growth Regulation
… a novel role for the Ajuba LIM proteins as negative regulators of the Hpo signaling pathway.
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Regulation of blood platelet function by nitric oxide
… oxide (NO) and prostacyclin (PGI₂) are strong negative regulators that modulate platelet adhesion, activation, aggregation, secretion and shape change. In this study the effects of NO on Ca²+ dependent and independent pathways of activation were investigated. The data produced during the course …
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Metabolomic approaches to understanding the auxin and ethylene response in Arabidopsis roots
… plant metabolites that have been shown to act as negative regulators of auxin transport. However, much remains to be learned about auxin and ethylene responses at the level of the metabolome. LC-MS analysis showed that a number of ions changed in response to both hormones in seedling roots. …
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Epigenetic Modulation In Braf Mutated Metastatic Colorectal Cancer
… models of BRAF V600E mCRC. Genes critical to negative regulation of Wnt/β-catenin signaling like RNF43 and Axin2 were significantly underexpressed in BRAF V600E mutant tumors when compared to their wild-type counterparts. These genes were hypermethylated in the xenograft models, which could be …
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