Global ETD Search
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Showing 1 to 2 of 2 for “"Nedd4-1"”.
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A study on PIP5Kalpha degradation by Nedd4-1-mediated ubiquitination
… that PIP5Kα, an isoform of PIP5K, interacts with Nedd4-1, a HECT domain-containing ubiquitin E3 ligase, and undergoes proteasomal degradation via Nedd4-1-mediated polyubiquitination at lysine 88, which leads to reduction in PIP2 levels. Furthermore, we found that the mutation K88R enhances the …
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The role of Ubiquitin ligases Nedd4-1 and Nedd4-2 in the brain and their crosstalk with alpha-synuclein and other dementia-related proteins
… cell-expressed developmentally derived 4 (Nedd4) is a family of proteins of which some members have been shown to target α-synuclein for breakdown through ubiquitination, both in cellular models, and in fly and rat PD models. It is therefore of interest to research the effect of deleting …