Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"Necrotizing"”.
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Comparisons of treatment strategies for necrotizing pancreatitis
… by Gram-negative organisms, can be combined with necrotizing pancreatitis, and it's mortality with organ failure is reported to be nearly 30%. Specific symptoms, contrast-enhanced abdominal computed tomography(CECT), Ranson's score, APACHE II score and confirmed infected necrosis by fine needle …
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Understanding Type A Clostridium perfringens in Foal Necrotizing Enteritis and Canine Acute Hemorrhagic Diarrhea
… role of type A Clostridium perfringens in foal necrotizing enteritis and canine acute hemorrhagic diarrhea is poorly understood. However, recently, we described a highly significant association between the presence of novel toxigenic C. perfringens and these specefic enteric diseases. These …
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Outcomes of Beta-Hemolytic Streptococcal Necrotizing Skin and Soft Tissue Infections and the Impact of Clindamycin Resistance
… streptococci are frequently implicated in necrotizing soft tissue infections (NSTI). Clindamycin administration may improve outcomes in patients with serious streptococcal infections. However, clindamycin resistance is growing worldwide, and resistance patterns in NSTI and their impact on …
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Distinguishing delivery and catalytic activity differences among G-protein deamidating protein toxins of the cytotoxic necrotizing factor (CNF) and Pasteurella multocida toxin (PMT) family through comparative analyses
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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Comparative analysis of cytotoxic necrotizing factor (CNF) toxins: Compatibility of cargo with delivery vehicle and identification of amino acid residues that modulate pH-dependent cytosolic cargo delivery
… thesis explores the suitability of the cytotoxic necrotizing factor (CNF) family as a model system for the development of Bacterial Toxin-Inspired Drug Delivery (BTIDD) platforms. The CNF family is notable among AB toxins in that there are nine full-length homologs and many CNF-like catalytic …
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Construction of CNFY-CNF1 Chimera Protein for Study of Differential pH Dependent Activity of CNF Proteins
… thesis we will explore the topic of cytotoxic necrotizing factors (CNFs) and show the creation of chimeric constructs to further test the details of CNF translocation into the cell. The CNF family of toxins is under the larger family of dermonecrotic AB toxins. These AB toxins have the ability …
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An analysis of neonatal mortality following gastro-intestinal and/or abdominal surgery in a tertiary hospital in South Africa
… ultra-short bowel length (12%); in patients with necrotizing enterocolitis, intestinal atresia and malrotation with volvulus, ventilation associated pneumonia (10%), associated congenital cardiac lesions (3%) and intestinal failure associated liver disease (1%). Most neonates (69%) who died were …
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SRV REGULATION OF STREPTOCOCCAL BIOFILM DISPERSAL AND ITS IMPACT ON VIRULENCE
… GAS also causes severe infections including necrotizing fasciitis. The mechanism for triggering the switch between mild and severe disease has yet to be discovered. Several groups have shown that regulation of protease production may play a role in the transition from localized to systemic …
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Enterostoma im Kindesalter
… indications were intestinal obstruction and Necrotizing Enterocolitis (NEC). More than half of the children were less than one month of age at the time of surgery. I observed an overall complication rate of 48.5% following enterostomy formation with stoma prolapse being the most common, but …
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Streptococcal colonization of host mucosal surfaces: a study of biofilm formation and dispersal
… otitis media, sepsis, a toxic-shock syndrome, necrotizing fasciitis, and the post-infectious sequelae acute rheumatic fever and acute rheumatic heart disease. Thus, rather than exploit a singular niche, GAS has evolved to colonize and disseminate within several physiologically distinct …
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Comparative analysis of Cronobactor sp. with respect to genomic diversity and physiology
… causing life-threatening diseases such as necrotizing enterocolitis and meningitis. This study for the first time presents growth data and whole genome comparisons for five different species of Cronobacter after the taxonomic revision by Iversen et al. (2008). Growth data for 28 bacterial …
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Dietary Intake and Bio-activation of Nitrite and Nitrate in Newborn Infants
… and treatment of newborn diseases such as necrotizing enterocolitis and hypoxic/ischemic injury are yet to be determined.</p>
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Investigation of growth and stress tolerance characteristics of Cronobacter spp.
… contaminated infant milk formula (IMF), causing necrotizing enterocolitis, sepsis and meningitis in neonatal infants. The work presented in this thesis involved the investigation and characterisation of a bank of Cronobacter strains for their ability to tolerate physiologically relevant stress …
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Signaling and Adhesive Mechanisms in Acute Pancreatitis
… from mild interstitial edematous to severe necrotizing disease. The overall mortality rate of AP is 8-9%. Specific treatment of AP is lacking which is partly related to an incomplete understanding of the basic pathophysiology behind the disease. It is widely held that premature …
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Abdominal surgery in very low birth weight neonates in a developing world neonatal unit- Short term outcomes and risk factors for mortality
… (SD 2.1) and 1102g (SD 197.8) respectively. Necrotizing enterocolitis was the most common (50%) surgical emergency. The leading postoperative complication was sepsis (37%). Fourty-two (81%) infants survived to discharge, the mean age at presentation 21 days (SD 21.1) with a mean hospital stay …
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Planting Seeds: A Naturalistic Inquiry Into the Perceptions and Experiences of WIC Peer Counselors as they Interact with Mothers Making their Infant Feeding Decisions
… otitis media, gastrointestinal illnesses, necrotizing enterocolitis, childhood obesity and diabetes (AAP, 2012; Rasmussen, Latulippe, and Yaktine, 2016). Breastfeeding benefits the mother by providing decreased risk of developing breast and ovarian cancers, hypertension, obesity, and …
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Understanding Human Astrovirus from Pathogenesis to Treatment
… infants where the virus has been associated with necrotizing enterocolitis, severe and persistent diarrhea, and even encephalitis and meningitis. Using our novel tools and models, we demonstrate that the FDA-approved broad-spectrum anti-infective drug nitazoxanide (NTZ) blocks astrovirus …
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Exploration of innate immune response during infectious bovine digital dermatitis and the evaluation of topical therapeutic treatment
… dairy cattle associated with ulcerative and necrotizing lesions. Due to the associated pain and lameness, DD is a recognized animal welfare problem and has economic implications associated with decreased milk production, lower reproduction rates, and premature culling. DD is of polymicrobial …
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