Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Necrotic cell death"”.
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Reactive Oxygen Species-Induced Necrotic Cell Death
Mechanisms of cell death extend beyond the simple apoptosis/necrosis relationship to include regulated modes of cell death that do not readily fit either of the classic descriptors. One such mechanism of cell death involves poly(ADP-ribose)polymerase-1 (PARP-1)-mediated cell death. …
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The Role of Bax and Bak in Necrotic Cell Death
… has been viewed as a non-regulated form of cell death. Recently studies have shown that necrosis, like apoptosis, can be a regulated form of cell death, suggesting the existence of a programmed necrotic pathway. For instance, necrotic cell death is inhibited in cells deficient for …
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Necrotic cell death: A novel outcome of BHPI-hyperactivation of the anticipatory unfolded protein response
… proliferation of and kills breast cancer cells expressing constitutive and antiestrogen resistant mutations, ERaY537S and ERaD538G, that are common in metastatic breast cancer and upregulate the UPR. Surprisingly, BHPI does not kill cancer cells through classical UPR activated, …
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N-ethylmaleimide sensitive factor (NSF) is a regulator of plasma membrane rupture and necrotic cell death
… of plasma membrane rupture, a hallmark of necrotic cell death, a genome-wide shRNA loss-of-function screen was performed. We identified SNARE complex members, mediators of canonical membrane fusion events, as necessary for Ca2+ and ROS-induced plasma membrane rupture andnecrosis. We …
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Transient receptor potential melastatin member 4 is the executioner protein for anticancer drug-induced necrotic cell death
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-12-01
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Atrx Inactivation and Idh1-R132H Drive Preferential Sensitivity to Proton Vs. X-Ray Radiotherapy In Glioma Stem Cells
<p><strong>Background:</strong> Glioma Stem Cells (GSCs) are self-renewable, treatment resistant cells in the glioma tumor mass known to promote tumor development. In contrast to traditional photon-based radiation therapy (XRT), proton radiation therapy (PRT) may induce more complex DNA damage and …
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Synthesis and Cytotoxicity Studies of Gold Nanoparticle Systems
… systems. A range of biomolecules including the cell-penetrating TAT peptide (YGRKKRRQRRR), mitogen-activated protein kinase (MAP kinase), streptavidin and fluorescent-labelled FAM-TAT peptide were successfully immobilised on the gold MPCs. The simplicity of the synthetic approaches and the …
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Reactive oxygen and nitrogen species production in cardiomyoblasts during hypoxia and reoxygenation
… of an adequate O2 supply; this may trigger cell death with pathological consequences in cardiovascular or neurodegenerative disease. Reperfusion is the restoration of an oxygenated blood supply to hypoxic tissue and can cause more cell injury. The kinetics and consequences of reactive oxygen …
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STAUROSPORINE-INDUCED APOPTOSIS/PROGRAMMED CELL DEATH
Apoptosis is the mechanism by which cells are programmed to die under a wide range of physiological and developmental stimuli. Three phases of the apoptosis process, (a) induction phase, (b) commitment phase and (c) degradation phase, have been described in interphase cells only. This study …
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Role of RIP3 in DNA damaging agent-induced breast cancer cell death
… a central player in “programmed” or “regulated” necrotic cell death pathway. Here we show that programmed necrosis is activated in response to chemotherapeutic agents and contributes to chemotherapy-induced breast cancer cell death. However, we also show that RIP3 expression is silenced in basal …
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Alterations in lymphocyte signalling produced by exposure to mercury
… (p-CMB) and ethylmercurithiosalicylate (TMS) on cell viability and kinetics of cell death, microtubules, F-actin, CD3 receptor expression, protein tyrosine phosphorylation (PTyr-P), intracellular calcium [Ca2+]i and responses to polarized signals in YAC-1 lymphoma cells were investigated. We …
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Thioredoxin-1 Inhibition Promotes MLKL Activation: Biochemical Insights Into a Suppressor of the Necroptotic Pathway
Necroptosis is an immunogenic caspase-independent cell death program. While mainly serving to defend against viral infection, dysregulated necroptotic signaling contributes to the pathology of a growing number of human diseases associated with inflammation, neurodegeneration, and ischemic injuries. …
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The Role of CK1 in Necroptosis and Confirmation of Amyloid-Like Fibers in Necroptosis Using 2D SDD-AGE
Necroptosis is a regulated necrotic cell death pathway, mediated by a supermolecular complex called the necrosome, which contains receptor-interacting protein kinase 1 and 3 (RIPK1, RIPK3) and mixed-lineage kinase domain-like protein (MLKL). Phosphorylation of human RIPK3 at serine 227 (S227) has …
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Finding Common Ground to Treat Primary and Metastatic Cancer: The Potential of Targeting Tumor Stroma
… stroma formed by accumulation of hematopoietic cells, mesenchymal stromal cells and extracellular matrix. The crosstalk between malignant epithelial cells and tumor stroma is becoming increasingly appreciated as a key determinant in tumor development, progression and metastasis, as well as …
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Prevention of Ischemia-Reperfusion Injury in the Rat Liver by Atrial Natriuretic Peptide
… to evaluate the influence of ANP on the mode of cell death occurring during cold ischemia and reperfusion and to elucidate the involved signal transduction pathways. Apoptotic cell death was mainly seen after cold liver storage, whereas necrosis was predominant in the reperfusion period. It could …
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Assessment of Cell Death Parameters in Bovine Parvovirus-Infected EBTr Cells
… be a cytolytic virus because it kills the host cells. However, the mechanism by which the virus causes cell death is not known. The work described in this thesis assessed different parameters of cell death in BPV infected embryonic bovine tracheal (EBTr) cells. There are several ways for viruses …
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Exploring the effects of classical immune activation on circuit excitability and cell viability in the mouse brain
… immune activation on circuit excitability and cell viability. To initiate inflammation, I administered lipopolysaccharide (LPS), an endotoxin derived from gramnegative bacteria, and interferon-gamma (IFNy), a cytokine typically released by lymphocytes, to brain slices on varying time scales. I …
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Photophysics of Organic Probes and their Applications in Bioimaging & Photodynamic Therapy
… which affords deeper tissue penetration and excellent three-dimensional (3D) images, is now being widely employed for bioimaging. This dissertation focuses on the design, synthesis, and photophysical characterization of new fluorophores, as well as desirable applications. Chapter 1 gives an …
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Immunotoxicity of Pesticide Mixtures and the Role of Oxidative Stress
… 1mM. These exposures caused both apoptotic and necrotic cell death in thymocytes as evaluated by 7-aminoactinomycin-D, Annexin-V/PI, and lactate dehydrogenase release assays. When cells were exposed to lindane+malathion, or lindane+permethrin, a significantly greater-than-additive cytotoxicity …
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Mechanism of Action of Antipsychotics, Haloperidol and Olanzapine in vitro
… mechanism of their cytotoxicity in a neuronal cell model using PC-12 cells. HP was found to be ineffective as a superoxide radical scavenger but appeared to be a potent scavenger of hydroxyl radicals with a rate constant of ~6.78 X 109 M-1s-1. Olz on the other hand was found to scavenge …
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