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Showing 1 to 1 of 1 for “"Necroptosis activation"”.
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Optimization of Receptor-Interacting Protein Kinase 2 (RIPK2) Inhibitors and Development of Mixed Lineage Kinase Domain-Like (MLKL) Activators
… (MLKL) pseudokinase as the final effector of the necroptosis cell death pathway. Previously, our lab discovered compound UH15-22 capable of binding MLKL and inducing necroptosis. However, the compound displayed off-target activity and low binding affinity. Therefore, we aimed to modify UH15-22 to …