Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Neat grinding"”.
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Crystal Engineering of Pharmaceuticals: Modulating Physicochemical Properties of Active Ingredients by the Formation of Cocrystals
… screening and preparation methods used include neat grinding (NG), liquid assisted grinding (LAG) and solution crystallisation. Antituberculosis drug, isoniazid, upon cocrystallisation with melamine, solubility has reduced as per high performance liquid chromatography assay, however, …
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Co-crystallisation of α,ω-dicarboxylic acids with nicotinamide and isonicotinamide
… (solvent-mediated crystallisation, solvent-drop grinding and neat grinding), with a view to investigate solvent and stoichiometric effects on the materials formed. Selected α,ω-alkanedicarboxylic acids (HOOC-(CH\(_2\))\(_{n-}\)COOH) were crystallised with nicotinamide for n = 0, 1, 2, 4, 5, 6, 7 …
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The evolution of organic synthesis in the solid-state approach: from grinding to mixing
… synthesis in the solid-state approach: from grinding to mixing’ focuses on the development of synthetic methodologies by addressing the problem of both sustainability and performance of these procedures. This problem represents a significant challenge, as the environmental impact of current …
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Processi di desolforazione mediante l'utilizzo di adsorbenti e catalizzatori solidi
… synthesis. Two different methods, called Neat Grinding (NG) and Liquid Assisted Grinding (LAG), were used to prepare NG-MOF and LAG-MOF-compounds, respectively. The chemical–physical features of both samples were analysed by X-ray powder diffraction, thermal analyses and N2 adsorption at …
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A novel solvent-free high shear technology for the preparation of pharmaceutical cocrystals
High shear melt granulation (HSMG) is an established technology for a production of densified granules. In this project, it was used as a novel solvent-free method for the preparation of cocrystals. Cocrystals produced by HSMG were compared to those prepared by Hot Melt Extrusion (HME) to …