Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Near Infrared Fluorescence"”.
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Biomedical studies of single -walled carbon nanotubes using near-infrared fluorescence
… been found to be a unique class of nanoscale near-infrared (NIR) fluorescence contrast agents that also exhibit novel therapeutic capabilities. In our first study, we found that cultured macrophage cells readily engulf individual nanotubes. The rate of cellular uptake of SWNTs was measured by …
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Leveraging Antibodies for Positron Emission Tomography and Near-Infrared Fluorescence Imaging of Cancer
… for PET and <sup>ss</sup>B43.13-IR800 for near-infrared fluorescence imaging and evaluated their <em>in vivo </em>performance in mouse models of human ovarian cancer. With this body of work, we hope to demonstrate the potential of antibodies as effective imaging agents for cancer.</p>
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USE OF NEAR-INFRARED FLUORESCENCE WITH INDOCYANINE GREEN IN SMALL ANIMAL SURGICAL ONCOLOGY AND IN CADAVERIC ANATOMICAL STUDY
Near-Infrared Fluorescence (NIRF) imaging is an emerging technology that enables real-time visualization of tissue perfusion and lymphatic structures through the use of fluorescent dyes such as indocyanine green (ICG). Although well-established in human surgery, its clinical application in …
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A bio-inspired, asynchronous, time-domain, multispectral imaging system for high dynamic range near-infrared fluorescence image-guided surgery
DSpace SAF Submission Ingestion Package generated from Vireo submission #13250 on 2019-02-08 at 11:41:37
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Capillary and microchip gel electrophoresis using multiplexed fluorescence detection with both time-resolved and spectral-discrimination capabilities: applications in DNA sequencing using near-infrared fluorescence
… the development of a two-color, time-resolved fluorescence microscope for the acquisition of both steady-state and time-resolved data during capillary and microchip electrophoresis. The utility of this hybrid fluorescence detector has been demonstrated by applying it to DNA sequencing …
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New optical materials containing isobenzofuran
… synthetic route to integrate isobenzofuran into near-infrared donor-acceptor type fluorophores. These dyes, the IBF-NIADs, exhibit red-shifted absorption and emission over corresponding isothianaphthene containing dyes, thus highlighting the effective proquinoid nature of isobenzofuran. With the …
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Optimization of Optical Nanosensor Response for the Detection of Anthracyclines Using a Binary Machine Learning Classifier
… for in vivo sensor development, as they exhibit near-infrared fluorescence in the tissue-transparent window and a robust response to their local environment. An emerging method for evaluating and optimizing SWCNT sensor response is through machine learning. In this study, anthracyclines …
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Goggle Augmented Imaging and Navigation System for Fluorescence-Guided Surgery
… assessment. This has propelled interest in fluorescence-guided surgery, due to availability of simple hardware that can achieve real-time, high resolution and sensitive imaging. Near-infrared fluorescence imaging is of particular interest due to low background absorbance by photoactive …
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Bioconjugation of aminated DNA as a method of rapid polymer library generation for Corona Phase Molecular Recognition
… alter both the intensity and the position of the fluorescence and absorbance profile. The length of the DNA sequence was found to change the small molecule's ability to alter the fluorecence spectra of the wrapped nanotubes. The EDC/sulfo-NHS reaction was done to conjugate the small molecules to …
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Applications of Molecular Switching and Logic
… (YES + 2PASS 1) and PASS 1 with H+ input, 700 nm near-infrared fluorescence output and 615 nm red light excitation. The gates carry an azaBODIPY (azaborodipyrromethene) fluorophore and an aliphatic tertiary amine as the H+ receptor where necessary. The H+-induced fluorescence enhancement factors …
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Annexin A5-Conjugated Polymeric Micelles For Dual Spect and Optical Detection of Apoptosis
… micellar nanoparticles dual-labeled with a near-infrared fluorescence fluorophores (Cy7) and a radioisotope (<sup>111</sup>In), named as <sup>111</sup>In-labeled annexin A5-CCPM. <em>In vitro</em> studies demonstrated that annexin A5-CCPM could strongly and specifically bind to apoptotic …
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Development and Evaluation of Paclitaxel-Loaded Liposomal Formulations for Targeted Drug Delivery to Breast Cancer
… bearing MDA-MB-231 breast cancer using near infrared fluorescence imaging showed that the accumulation of tumor vasculature targeted long-circulating liposomes (LCL) in the tumor was significantly less than non-targeted LCL at 48 h. The accumulation of these liposomes in the peritoneal …
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Development of an αᵥβ₆-Binding Peptide for In Vivo Applications: Modulation of Serum Stability and Biodistribution
… of H2009.1 tetramer in human serum. In vivo near-infrared fluorescence (NIRF) imaging shows that N-terminal capping also decreases kidney accumulation of this peptide at short time periods while maintaining targeting to the tumor for up to 72 hrs. To further decrease off-target accumulation, …
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Multi-modality Imaging to Determine the Role of Calcification and Inflammation on Restenosis Rates Following Lower Limb Angioplasty
… PTA was studied (compared to plain PTA) using near infrared fluorescence-optical coherence tomography hybrid imaging (NIRF-OCT) and plaque burden assessed by intravascular ultrasound (IVUS), in the experimental arm (EA). 40 patients were used for formal analysis. 14 patients (35%) reached the …
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Photochemical Tailoring of Single-Wall Carbon Nanotubes by Photoexcited Sodium Hypochlorite
… electronic transitions that allow for discrete near-infrared fluorescence spectra. These optical properties offer the potential for bioimaging applications because the wavelengths of semiconducting SWCNT emission fall within the biological window and are nearly free of autofluorescence …
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Near Infrared Fluorescent Choline Kinase Inhibitors for Cancer Imaging and Therapy
… the most promising choline-mimetic with inherent near infrared fluorescence. Attenuation of choline phosphorylation by JAS239 in human breast cancer cells was observed using 14C-choline radiotracing and high-resolution 1H MRS. Microscopy was used to explore the interaction of JAS239 with the ChoKa …
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Src Homology 2 Domain-Containing 5’-Inositol Phosphatase-2 (Ship2) Is An Effector of Lymphatic Dysfunction
… we combined investigational, non-invasive near-infrared fluorescence lymphatic imaging (NIRFLI) and next generation sequencing (NGS), to phenotype and genotype human subjects with familial lymphedema. We discovered that mutations in src homology 2-domain containing 5’-inositol phosphatase-2 …
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Detection and Quantification of Single-walled Carbon Nanotubes in Environmental and Biological Samples for Evaluation of Fate, Transport and Bioaccumulation
… distribution, transport and bioaccumulation. The fluorescence resulting from the unique band gap of each species of semiconductive SWCNT allows the detection and quantification of a bulky SWCNT sample using near infrared fluorescence spectroscopy (NIRF). NIRF is highly sensitive to detect SWCNT in …
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Construction and Performance Optimization of Bioconjugated Nanosensors for Early Detection of Breast Cancer and Pro-inflammatory Diseases
… due to the unique characteristics of their near-infrared fluorescence emission, including tissue transparency, photostability, and various chiralities with discrete absorption and fluorescence emission bands. Additionally, the optoelectronic properties of SWCNT are sensitive to the …
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Photochemistry of single-walled carbon nanotubes in the aquatic environment, and their extraction from soils
… Evidence for transformation includes UV-VIS and Near Infrared Fluorescence (NIRF) fading, and an increase in defects (sp<sup> 3</sup> carbon), as observed through Raman analysis. While more rapid fading occurred under light, changes in the fluorescence of the SWCNTs also occurred in dark samples, …
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