Global ETD Search
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Showing 1 to 8 of 8 for “"Nav1.8"”.
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Verhalten von C-Fasern der Maus während repetitiver elektrischer Stimulation : Bedeutung für die Fasererregbarkeit und die Rolle von Ih und Nav1.8
… in Mäusen mit Inaktivierung des Gens von Nav1.8 kam es vor allem bei den hitzeempfindlichen Fasern häufiger zu Leitungsblocks, die Latenzänderungen waren geringer als bei den Wildtyp-Tieren. Ströme durch diesen Kanal scheinen einerseits für die Leitungssicherheit der Fasern eine Rolle zu …
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Sodium channel diversity in the vestibular ganglion : evidence for Nav̳1.5-like and Nav̳1.8-like currents
… resembled current previously described for the Nav1.5 subunit, and a slower current with a depolarized voltage range of inactivation (midpoint ~-30 mV) which had properties consistent with Nav1.8 channels. All neurons also expressed TTX-S Nav currents with similar properties to those previously …
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Functional Regulation of Ion Channels in Dorsal Root Ganglion Neurons by Magi-1: Implications in Pain Signaling
… channels (KNa) family. This study will focus on Nav1.8, which is preferentially expressed in pain-sensing Dorsal Root Ganglion (DRG) neurons along with the KNa channel subunits called Slack and Slick. The membrane expression of Nav1.8 channels (promotes nociceptor excitability) and KNa channels …
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The impact of reduced neuronal p75NTR expression on sensory neuron phenotype and associated glia
… nociceptive state namely, the sodium channels NaV1.8 and NaV1.9, the nerve growth factor receptor TrkA, the potassium channel Kir4.1, glial fibrillary acidic protein (GFAP), SGC p75NTR, connexin 43, we intrathecally infused p75NTR anti-sense oligonucleotides (AS OGN), previously shown by Obata …
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Isoform-Specific Roles of Extracellular Signal-Regulated Kinases in Pain
… deletion of ERK2 in nociceptors: ERK2f/f;NaV1.8-Cre) were used. Although both isoforms are activated: phosphorylated) following inflammation, deletion of ERK1 had no effect in several models of chemical nociception, inflammatory pain, and neuropathic pain. In contrast, conditional deletion …
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Studies on voltage-gated sodium channel β3 subunit structure and cancer-related functions using single-chain variable fragment antibodies and bioinformatics
… more β-subunits. In humans, nine types of VGSC Nav1 channel α subunit isoforms (Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.6, Nav1.7, Nav1.8, and Nav1.9) and four types of β subunit isoforms (β1, β2, β3, and β4) (gene names: *SCN1-11A* and *SCN1-4B*) have been identified in various tissues. …
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Evolution of Toxin Resistance in the Grasshopper Mouse: A Comparative Genomics Perspective
… functional modifications in the sodium channel Nav1.8 that decrease the effect of the toxins. This raises interesting questions: What are the molecular adaptations underlying toxin resistance in Onychomys? What genes contribute to pain and toxin response? Which sodium and potassium channels are …
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Angiotensin II signalling in sensory neurons
… expressed the nociceptive markers TRPV1 and Nav1.8. This population of Ang II-sensitive neurons could be divided in two, with one subpopulation expressing Tmem45b and binding the non-peptidergic marker isolectin-B4 (IB4), while the other subpopulation lacked both Tmem45b and IB4 binding. The …