Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Nav1.7"”.
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A Structural Basis for Neuropathic Pain Syndromes Associated with Mutations in Nav1.7
… and trigeminal ganglion (TG) sensory neurons. Nav1.7 is the most abundantly expressed isoform in DRG and TG neurons, and an isoleucine to valine mutation at residue 136 in the voltage- sensing domain (VSD) results in the disease, inherited erythromelalgia (IEM). From functional studies, it is …
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Interplay between collapsin response mediator protein 2 (CRMP2) phosphorylation and sumoylation modulates NaV1.7 trafficking
The voltage-gated sodium channel Nav1.7 has gained traction as a pain target with recognition that loss-of-function mutations in SCN9A, the gene encoding Nav1.7, are associated with congenital insensitivity to pain, whereas gain-of-function mutations produce distinct pain syndromes due to increased …
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Studies on voltage-gated sodium channel β3 subunit structure and cancer-related functions using single-chain variable fragment antibodies and bioinformatics
… more β-subunits. In humans, nine types of VGSC Nav1 channel α subunit isoforms (Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.6, Nav1.7, Nav1.8, and Nav1.9) and four types of β subunit isoforms (β1, β2, β3, and β4) (gene names: *SCN1-11A* and *SCN1-4B*) have been identified in various tissues. …
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Exploring Pain Neurobiology: Molecular Investigation of Genetic Sensory Disorders
… to the voltage-gated sodium channel (VGSC) Nav1.7. Studies revealed that all mutants were non-conducting, independent of protein folding or membrane trafficking defects, implying critical intramolecular roles for the affected residues. Through this project I developed a workflow for rapid …
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Structural and functional role of the extracellular loops and C-terminal domain of the voltage-gated sodium ion channel
… mediates various regulatory roles. The subtype Nav1.5 is primarily expressed in the heart where it initiates the cardiac action potential whereas Nav1.7 is found in the peripheral nervous system where it is associated with nociception. Various Nav associated pathologies have been associated with …
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TIMP-1 as a Modulator of Inflammatory Pain
… and downregulates expression of the ion channel, Nav1.7 in the DRG. In our last set of experiments, we sought to further define this connection and asked whether TIMP -1 could regulate pain and ion channel expression through its known interactome. We found that peripheral knockdown of CD63, a …
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Towards a more ethical animal model in biomedical research
… was designed to be combined with a floxed Nav1.7 ion channel mouse model. When a 4- hydrotamoxifan class small molecule is fed to the mouse, Cre recombinase expression in the peripheral nervous system will disrupt function of the ion channel involved in inflammatory and mechanosensory pain. …
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Molecular Basis of Mechanosensitivity
… the sodium selective voltage gated channel, Nav1.7, and calcium selective voltage gated channels, Cav1.2 and Cav1.3, were not found to display major mechanosensitive properties. In a complimentary approach, I performed a screen of 10 different cell lines using the poking assay to identify …