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Showing 1 to 8 of 8 for “"Nav1.6"”.

  1. Identifying Protein Interactors of Voltage-Gated Sodium Channel Nav1.6 in Native Tissue

    Goode, Nana AboadweThe University of Texas Medical Branch at Galveston2023

    … to discover protein partners that interact with Nav1.6, a predominant isoform in the central nervous system, in different environmental conditions, with the premise that these could serve as druggable targets to improve treatment outcomes.

    utmb Repository record

  2. Targeting protein: protein interaction sites for drug development against voltage-gated sodium channels

    Ali, Syed RydwanThe University of Texas Medical Branch at Galveston2019

    … interface of FGF14 as critical for binding to Nav1.6 channels. Based on this information, we have identified a short sequence on FGF14 and designed a peptidomimetic (ZL181) fragment as an effective probe for modulating Nav1.6 channels as measured by luciferase-based assay. This peptidomimetic …

    utmb Repository record

  3. Regulation of signaling and function of the voltage-gated sodium channel complex by protein:protein interactions

    Wadsworth, Paul AThe University of Texas Medical Branch at Galveston2020

    … Specifically, we focused on the PPI between Nav1.6 and its regulatory protein, fibroblast growth factor 14 (FGF14). Using a newly developed assay we screen cellular pathways followed by biophysical validation, we discovered a mechanism by which the JAK2 tyrosine kinase might directly …

    utmb Repository record

  4. Characterization of the Increased Risk of Attention Deficit Hyperactivity Disorder Following Early-Life Exposure to Deltamethrin

    Tapia, Cynthia MarieThe University of Texas Medical Branch at Galveston2020

    … and medium spiny neurons which highly express Nav1.6- both of which are key components of reward circuitry. These studies are further complemented by identification of behavioral aberrations that typify the human pathophysiology of ADHD. Together, this data identifies a possible mechanism …

    utmb Repository record

  5. Structural and functional characterization of signaling protein complexes

    NG CHERLYN2009

    … to two high affinity sodium channel isoforms Nav1.4 and Nav1.6 was characterized.

    nus Repository record

  6. CELLULAR ALTERATIONS OF ADULT HIPPOCAMPAL NEUROGENESIS IN THE FGF14−/− MOUSE MODEL

    Alshammari, Musaad AliThe University of Texas Medical Branch at Galveston2021

    … the AIS, the voltage-gated sodium channel 1.6 (Nav1.6) α-subunit––an ion channel responsible for generating and propagating action potentials in mature neurons. My observations revealed a significant decrease in the Nav1.6 axonal expression level in the DG of Fgf14−/− mice. Knowing this, I …

    utmb Repository record

  7. Towards a more ethical animal model in biomedical research

    Najjar, Deborah AnneMassachusetts Institute of Technology2018

    … was designed to be combined with a floxed Nav1.7 ion channel mouse model. When a 4- hydrotamoxifan class small molecule is fed to the mouse, Cre recombinase expression in the peripheral nervous system will disrupt function of the ion channel involved in inflammatory and mechanosensory pain. …

    mit Repository record

  8. Studies on voltage-gated sodium channel β3 subunit structure and cancer-related functions using single-chain variable fragment antibodies and bioinformatics

    Liu, HengruiUniversity of Cambridge2024

    … more β-subunits. In humans, nine types of VGSC Nav1 channel α subunit isoforms (Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.6, Nav1.7, Nav1.8, and Nav1.9) and four types of β subunit isoforms (β1, β2, β3, and β4) (gene names: *SCN1-11A* and *SCN1-4B*) have been identified in various tissues. …

    cambridge Repository record