Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Natural product discovery"”.
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Natural Product Discovery from a Streamline Environment-to-Bioassay Pipeline
Natural products (NPs) have long been central to drug discovery as sources of new therapeutics and drug leads. Despite major advances in microbial NP discovery over the past century, the earliest stages of the workflow—from sample collection to library generation—have remained largely unchanged. …
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Metagenomics-Based Tryptophan Dimer Natural Product Discovery and Development Pipeline
<p>Most microbial natural product discovery programs rely on the growth of bacteria in the laboratory, yet it is now well established that the vast majority of bacteria in the environment have not been cultured, particularly from the diverse soil microbiota. By extracting DNA directly from soil …
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Practical applications of genomics to natural product discovery and biosynthesis
Natural products, generally defined as metabolites of biotic origin, have a long history as medicines and have remained a fruitful source of new drug leads for multiple diseases in the modern age. Arguably the largest asset of natural products, and a pitfall of synthetic compound libraries, is the …
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Stimulating antibiotic development by targeting virulence and facilitating natural product discovery
… biosynthesis and was also shown to inhibit toxin production in other pathogens known to harbor similar biosynthetic clusters. Another approach to the problem of finding new antibiotics can be found in facilitating natural product discovery. Many antibiotics are derived from natural products but …
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Natural product discovery and engineering at the protein, pathway, and genome scales
For centuries, mankind has turned to natural sources for cures, remedies, and ways to improve its quality of life. It was not until the discovery of the antibiotic penicillin in 1928, however, that natural products – small molecule secondary metabolites produced by a variety of organisms for a …
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Natural product discovery in actinomycetes and investigation into the regulation of SPI-1 in salmonella typhimurium
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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Natural product discovery: studies on the phenolic antioxidants from Smilax Glyciphylla and the synthesis and formation of Guaiane Sesquiterpenoids.
… within this thesis is positioned in the field of natural product (NP) chemistry and covers three main integrated studies along with some additional explorations. These studies not only included the isolation and characterisation of NP but also involved total syntheses of various NP and related …
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Development and application of synthetic biology tools for natural product research
Natural products, or secondary metabolites, usually refer to bioactive small molecules produced by microorganisms or plants. To date, thousands of natural products have been characterized which reveal diverse structures and bioactivities, making it an ideal resource for discovering drug leads and …
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The characterization of two novel class II lanthipeptides from Thalassomonas viridans by heterologous expression in Escherichia coli
… microorganisms, there is an urgent need for the discovery and development of novel antimicrobial agents. In the past, natural products have been a source of successful drug candidates for treating diseases. However, the rate of natural product discovery has largely plateaued due to the …
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The characterization of two novel class II lanthipeptides from thalassomonas viridans by heterologous expression in escherichia coli
… microorganisms, there is an urgent need for the discovery and development of novel antimicrobial agents. In the past, natural products have been a source of successful drug candidates for treating diseases. However, the rate of natural product discovery has largely plateaued due to the …
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Drug Discovery in Redox Biology: From Natural Products to Structural Biology
… targets in cancer and infectious diseases. Natural products provide structurally diverse redox-active scaffolds capable of modulating oxidative stress and redox sensitive signaling pathways. The genus Rinorea (Violaceae) is metabolically diverse yet remains largely underexplored. Rinorea …
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Heavy metal inducible antimicrobial activity of streptomyces spp. isolated from the Leadhills and Wanlockhead lead mines in Scotland, Uk
… context and molecular evidence towards the discovery of the gene clusters responsible for antibiotic biosynthesis.Our findings highlight the potential of using heavy metals for activation of silent biosynthetic metabolite gene clusters in Streptomyces isolated from extreme environments for …
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Repurposing Antibacterial Compounds and Natural Products to Combat Vancomycin-Resistant Enterococci
… strategies to address this challenge: natural product discovery and drug repurposing. The first study investigated two drug candidates, CRS3123 and ridinilazole, originally designed to target Clostridioides difficile, for their activity against VRE. Both compounds showed exceptionally …
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Discovering novel natural products from bioactive plants and bacteria
… plants have evolved to produce a myriad array of natural products that are of biomedical importance. One group of valuable natural products is polyketides, which are known to be antiviral, antibacterial, and anticancer. In my first project, I attempted to develop an efficient strategy for cloning …
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Reengineering and Discovery of Nonribosomal Peptide Synthetases
Nonribosomal peptides are an important class of natural products including the life-saving antibiotics penicillin and vancomycin and the deadly microcystins and cereulide. This important category of natural products is thus a focus of many research labs around the world, including the Kelleher lab. …
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Nucleoid-Associated Proteins of Streptomyces coelicolor: Discovery and Functions
… biosynthetic gene clusters is a key concern in natural product discovery as these clusters are often transcriptionally silent (“cryptic”) under normal laboratory conditions, making the initial characterisation and heterologous expression of the products they encode problematic. The role of the …
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Genomics as a tool for natural product structure elucidation
Natural product discovery is in the midst of a transition from a largely serendipity-based effort to an informatics-driven one. For most of the 20th century, natural product discovery relied on genome-blind bioassay-guided isolation. This was initially exceptionally productive, yielding the golden …
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Using Multiple Screening Strategies to Biologically and Chemically Characterize Natural Products
Natural products play an important role in the discovery and development of therapeutics and biological probes. However, in recent decades therapeutic screening efforts have moved away from using natural product libraries, instead opting for large synthetic molecule library. This move has …
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Mining Marine Environments for Novel Antimicrobial Biologics
… sponge-associated bacteria for the purposes of natural product discovery. Overall, this work displays that the Hexactinellid sponges investigated are a promising source for the discovery of novel bacterial species and antimicrobial candidates.
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Studies of new natural products and their biosynthesis spearheaded by high-resolution mass spectrometry
Many natural products with anticancer, antibiotic, and immunosuppressant activity are synthesized by non-ribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs). In NRPS and PKS biosynthesis, monomer units are incorporated into a growing natural product chain in an assembly line …
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