Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"Natural killer cell"”.
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Natural Killer Cell Responses to Human Cytomegalovirus
… infection in the face of robust humoral and cell-mediated immune responses. In spite of significant efforts, the mechanisms implicated in protective immunity during HCMV infection are still not fully understood. To evade the potent and diverse natural killer (NK) cell mediated- effector …
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Licensed to kill. Towards Natural Killer cell immunotherapy.
Contains fulltext : 87167.pdf (Publisher’s version ) (Open Access)
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Natural Killer Cell Recruitment and Activation Following Orthopoxviral Infection
… host responses for resistance and survival. Natural killer: NK) cells provide an essential innate response to infection through direct lysis of infected cells and cytokine production. The innate anti-viral response following infection is associated with NK cell population expansion in …
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Immunogenetic regulation of Natural Killer cell function in pregnancy
Uterine NK (uNK) cells are a distinct subset of NK cells in the decidua of humans and rodents during pregnancy, which are essential for remodelling of the spiral arteries supplying the feto-placental unit. Similarly to peripheral NK cells, uNK cells express Natural Killer receptors (NKRs) that …
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Natural Killer Cell Responses in Chronic Hepatitis C Virus Infection
… viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. Liver injury and disease progression in hepatitis C virus infection is driven by the host immune response. Previous research has largely focused on the contribution of virus-specific T cells to this process. However, in chronic …
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The role of uterine natural killer cell-inhibition in pregnancy
Education of natural killer (NK) cells is a genetically determined process that primes NK-cell activity upon the binding of their inhibitory receptors to self-ligands. Although NK-cell education is predictable and measurable in the laboratory, its biological significance is unknown. This thesis …
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Alternate pathways of cytotoxic T lymphocyte and natural killer cell activation
… transmembrane glycoprotein found on a variety of cells including those of myeloid and lymphoid origin. CD44 is highly conserved among various species and is involved in the homing of lymphocytes and monocytes to lymph nodes, Peyer's patches, and sites of inflammation. In the present study, we …
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A License to Kill: Understanding Natural Killer Cell Licensing to Fight Cancer
<p>Natural killer (NK) cell education is an essential developmental process for NK cell effector function, that renders some NK cells “licensed” and others “unlicensed” (with heightened or lowered effector function potential, respectively) against tumor and targets lacking self-molecules. However, …
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Bidirectional Natural Killer Cell and Dendritic Cell Interactions in HIV-1 Pathogenesis
Natural killer (NK) and dendritic cell (DC) interactions are pivotal for the development of immune responses, which lead to bidirectional NK:DC activation. In HIV-1 infection, both NK cell and DC function are impaired, resulting in dysfunctional NK:DC crosstalk. We demonstrate that NK:DC …
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Augmentation of Natural Killer Cell Activity by CORYNEBACTERIUM PARVUM: Involvement of Lipoxygenase Pathway
… release assay was used to measure natural killer (NK) cell activity associated with <em>Corynebacterium parvum</em> (CP) injection against YAC-1 and MBT-2 targets. The peritoneal exudate cells from intraperitoneal treatment of CP at different dosages consistently gave higher …
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Modulation of Ly49A+ Natural Killer Cell Licensing by Major Histocompatibility Complex Class I Alleles
Natural killer: NK) cells are innate immune lymphocytes that react to cells lacking self-MHC: major histocompatibility complex) class I molecules, such as transformed or virally infected host cells and allogeneic bone marrow. This reactivity is mediated by inhibitory receptors for MHC class I that …
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Membrane Bound Il21 Promotes Natural Killer Cell Expansion Through Mir 124-3P Mediated Regulation
<p>Natural Killer (NK) cells are cells of the innate immune system that act as first line of defense against viral infections and participate in tumor immune surveillance. NK cells do not cause graft versus host disease (GvHD), or require prior antigen exposure to exert anti-tumor activity, hence …
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Identifying regulators of natural killer cell development through CRISPR screening of common lymphoid progenitors
Natural Killer (NK) cells are cytotoxic lymphocytes that perform a key role in the innate immune response, lysing abnormal host cells such as those that are cancerous or virally infected. They are the prototypic member of the innate lymphoid cell (ILC) family, which also comprises the functionally …
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Down-Regulation of Natural Killer Cell Activation in Response to Influenza Virus in Older Adults
… vaccine efficacy in elderly people. Type I T cell (Thl)-mediated immunity plays a significant role in Immune responses to influenza infection and vaccination. Natural killer (NK) cells secrete significant amount of IFN-7 , a hallmark Thl cytokine, in response to influenza infection. How aging …
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Magnetic Resonance Imaging of a Natural Killer Cell Therapy in a Mouse Model of Prostate Cancer
… resonance imaging (MRI) techniques to study natural killer (NK) cell therapy in a nude mouse model of prostate cancer. Cellular MRI, anatomical MRI and hyperpolarized 13C spectroscopy were used to study various aspects of the model. Methods: The cells used were KHYG-1 NK cells and PC-3M …
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The Roles of miR-155 and miR-15/16 in Natural Killer Cell Function and Maturation
<p>Natural Killer (NK) cells are a crucial component of the immune system, with a role in both early host defense against pathogens and tumor immunosurveillance. NK cells develop in the bone marrow from a common lymphoid precursor, along with T and B cells, but undergo a separate education process. …
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Augmenting Natural Killer cell antibody binding to enhance ovarian and prostate tumor cell killing via ADCC
… cause of cancer-related deaths worldwide. Natural killer (NK) cells are cytotoxic lymphocytes that rapidly kill tumor cells via antibody-dependent cell-mediated cytotoxicity (ADCC). ADCC is exclusively mediated by the IgG Fcγ receptor (FcγR) CD16A, and many clinically successful therapeutic …
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