Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"Natural compounds"”.
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Characterization of Redox Active Natural Compounds in Chlamydia Infection
Trachoma is the leading cause of blindness worldwide, induced by the intracellular bacterial pathogen Chlamydia trachomatis (Ct). Ct is also one of the most widespread sexually transmitted infections (STIs), with over 2.8 million infections in the US alone. The most serious sequelae result from …
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Application of nanotechnologies for the therapeutic use of natural compounds
Natural compounds represent a valuable source of bioactive molecules with vast pharmacological potential; however, despite their therapeutic potential, the clinical application of natural extracts is often influenced by physicochemical and pharmacokinetic limitations, such as poor water solubility, …
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Part1. Relative antioxidant efficiency of synthetic and natural compounds; Part 2. Synthesis, characterization of cysteine oligopeptides and assessment of their antioxidant activity
… (BHT), santoquin, tocopherols and extracts of naturally occurring materials such as green tea, ginger root, kelp etc. Assessment included the classical active oxygen method (AOM) and gas chromatographic - mass spectrometry determinations of oxidative degradation products...The second part of …
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Využití technik hmotností spektrometrie v analýze přírodních látek
… of mass spectrometry in the analysis of natural compounds This diploma thesis deals with the topic " Using of techniques of mass spectrometry in the analysis of natural compounds ". The aim of the work was to create a research work and describe the profile of alkaloids in individual …
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Attempts to Synthesize 5-(P-Acetoxyphenyl)-3-Carbomethoxy- 4,6-Dicarboethoxy-Hexa-Hydroindanedione-l,7-Delta 3-9
… classes of substances found In nature are compounds from the hydrocarbon cyclopentanoper-hydrophenanthrene, which for the sake of simplicity are called steroids". These natural compounds are oxygenated, alkyl-substituted derivatives of the parent hydrocarbon, and have the ring system given …
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Acylation of 1-(p-Acetoxyphenyl)-2,6-Dicarbethoxy-Cyclohexanedione-3,5
… classes of substances found in nature are compounds derived from the hydrocarbon cyclopentanoperhydrophenanthrene, which for the sake of simplicity are called steroids." |These natural compounds are oxygenated, alkyl-substituted derivatives of the parent hydrocarbon, and have the ring …
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Toxicogenomics of Apis Mellifera
… to have evolved to respond specifically to natural compounds encountered in the hive environment, and that honey bees have a limited capacity to metabolize synthetic pesticides. Certain beekeeping practices, including miticide use and artificial feeding supplements, may affect the ability of …
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Development and Application of a Novel Assay for Rapid Identification of Cellular Prion Protein Modulators
… screening (HCS) to identify small molecules, natural compounds, and genetic modulators capable of downregulating PrPC levels. A broad range of chemical libraries, including FDA/EMA-approved drugs and computationally selected candidates, were screened, leading to the identification of promising …
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Understanding protein misfolding diseases through the development of biophysical methods
… aggregation of Aβ and iii) identify a range of natural compounds to inhibit the aggregation of Ab. We begin with an introduction of AD, with a specific emphasis on its association with Aβ aggregation. We then describe in detail the characterisation of neurotoxic oligomeric species of Aβ …
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Studies Towards The Novel Synthesis Of Benzoisochromane Quinone Polyketides
… naphthazarin core, only exhibited by one other natural compound, by a C-C glycosidic bond and an aldol like bond. The mechanism of enzymatic attachment of this substituent is currently unknown. This project aimed to devise a novel and elegant synthesis towards the granaticin aglycone and other …
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Identification of potential antibiofilm hit compounds from two African natural product database against multi-drug resistant staphylococcus aureus: an in silico study
… patchy data. The complex chemical diversity of natural compounds makes them a reservoir of bioactive molecules for drug discovery. This study seeks to identify effective potential antibiofilm compounds from a query dataset compiled from two African natural product databases (SANCDb and AfroDb). …
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Comparative chemical ecology, behaviour, and evolutionary genetics of acanthodactlylus boskianus (Squamata: Lacertidae) : comparative chemical ecology, behaviour and evolution
… the secretions resulted in the identification of natural compounds not previously reported in reptiles, glycerolmonoethers and monoglycerides.The secretions seem to be used as scent pheromones, which are involved in signal evolution processes resulting in divergence of the chemical fingerprints of …
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Aplikace substituovaných pyranonů v chemii dendralenů a totální syntéze přírodních látek
… in dendralene chemistry and total synthesis of natural compounds This thesis deals with the preparation of substituted pyranones via the sequence of two palladium- catalyzed reactions, Migita-Stille coupling and Tsuji-Trost allylic transposition. The products obtained were applied in the …
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Synthesis of the Antimalarial Flindersial Alkaloids
The concept of mimicking nature to synthesize natural compounds has been successfully demonstrated in the synthesis of all the anti-malarial Flindersia alkaloids. Previous work on the biosynthesis of the related natural products borreverine and isoborreverine inspired us to synthesize racemic …
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Investigating the efficacy of pomegranate extract as an antioxidant in multiple high-lipid model systems
… Previous research has evaluated synthetic and natural compounds in a plethora of matrices to compare antioxidant efficacies. Because of the intricate nature of antioxidants, their solubility and differences in application, expansive research must be done to qualify antioxidants of similar …
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Pharmacologically impeding glioblastoma tumour motility through simultaneous inhibition of aquaporin-1 and ion channels
… agents that potently impair GBM cell motility. Natural compounds (xanthurenic acid and caelestine C) and semi-synthetic amides (SN00756563, SN00756564 and SN00756565) decreased invasion in U87-MG and U251-MG glioblastoma cell lines, revealing previously unknown anti-invasive activities of these …
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A Phytochemical Analysis of Secondary Metabolites in Eupatorium Serotinum
<p>Phytochemistry, a subset of Natural Products Chemistry, studies chemically derived products from natural substances. Advances in this field have important applications in medicinal research due to the distinctive and unique properties of natural compounds. All metabolites are produced from the …
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Coronavirus Replication Inhibition by Herbal Extracts
… I screened several herbal extracts from natural compounds affecting replication of mouse hepatitis virus (MHV), the prototype coronavirus, infected cells. The reduced virus production was analyzed by plaque assay. The replication inhibition of MHV by herbal extracts in terms of RNA …
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Repurposing Antibacterial Compounds and Natural Products to Combat Vancomycin-Resistant Enterococci
… strategies to address this challenge: natural product discovery and drug repurposing. The first study investigated two drug candidates, CRS3123 and ridinilazole, originally designed to target Clostridioides difficile, for their activity against VRE. Both compounds showed exceptionally …
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