Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Natural compound"”.
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The total synthesis of aristolindiquinone
Aristolindiquinone (1), a novel natural compound possibly: possessing anti-fertility activity, was synthesized via two independent routes. First, a Stobbe reaction unambiguously gave the naphthalene nucleus with the required substitution pattern (3,8-dioxygenated-2,5-dimethyl naphthalene), starting …
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Studies Towards The Novel Synthesis Of Benzoisochromane Quinone Polyketides
… naphthazarin core, only exhibited by one other natural compound, by a C-C glycosidic bond and an aldol like bond. The mechanism of enzymatic attachment of this substituent is currently unknown. This project aimed to devise a novel and elegant synthesis towards the granaticin aglycone and other …
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Preclinical Development of a Pharmacologic Agent for the Treatment of Recurrent Acute Pancreatitis
… limiting progression to CP. Apigenin is a natural compound with known anti-inflammatory, anti-proliferative, and pro-apoptotic properties. In a mouse model of RAP, the natural compound, apigenin, protected the pancreas from histologic damage while minimizing fibrosis. It was hypothesized …
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BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY
… cells. Finally, we identified an ID2 inhibitor, natural compound Helichrysetin.
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Synthetic Work Towards Salvinorin A
Salvinorin A is the active compound in the plant Salvia divinorum, commonly known as salvia. It is a highly selective kappa opioid agonist, which gives it potent hallucinogenic and potent analgesic properties. The natural compound was isolated and characterized in 1982, and a multitude of …
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Investigating the potential anti-diabetic effect of sulforaphane
… study, I investigated whether sulforaphane, a natural compound derived from cruciferous vegetables, can prevent high-fat (HF) diet-induced obesity and diabetes in C57BL/6 mice. Dietary intake of sulforaphane (250 mg/kg diet) prevented hyperglycemia and increased insulin sensitivity in HF …
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Field Amplified Sample Stacking on Amyloid Beta (1-42) Oligomers using Capillary Electrophoresis
… were smaller than proto-fibrils. Future work on natural compound inhibition studies using CE are recommended to see how those inhibitors target Aβ1-42 species that are less than or equal to 100 kDa.</p>
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A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death
… agents in prostate and other cancers. The natural compound resveratrol has similar properties: increasing insulin sensitivity, suppressing adipogenesis, and killing cancer cell lines in vitro. However, in vivo tumor xenografts acquire resistance to resveratrol by an unknown mechanism, while …
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Identification of genipin as a potential treatment for type 2 diabetes
… of T2D. This project aimed to examine whether natural compound genipin promotes intestinal GLP-1 secretion and exerts anti-diabetic effects. I found that genipin rapidly increased GLP-1 secretion from intestinal L-cells, with 10 and 100 μM concentration inducing significant incretin hormone …
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Novel Aspects of the Response to Cellular Stress and Intracellular Bacterial Pathogens
… survival by highlighting a novel role for the natural compound isoginkgetin as an inhibitor of the 26S proteasome. Disruption of protein homeostasis via isoginkgetin impairs the ability of cancer cells to mount stress responses and sensitizes various cancer cell types to apoptotic cell death …
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The search for small molecule inhibitors of histone acetylation
… acid and the<br/>azumamides. Anacardic acid is a natural compound found in cashew nut shell liquid. Its structure<br/>consists of salicylic acid and a long hydrophobic alkyl tail, which suggests that the compound<br/>would be rather insoluble and unable to permeate cells. However, it has been …
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Identification of natural product stereochemistry via calculation of ECD spectra
… available antibiotics are obtained from natural products, secondary metabolites of bacteria or other living organisms. Due to the importance of this class of compounds in medicinal chemistry and growing drug resistance, efforts to discover, characterize and isolate new or improved …
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Curcumin as a therapeutic agent for the treatment of rheumatoid arthritis and cancer
… the inflammatory pathway, and so the use of this natural compound for RA, NSCLC and GBM can improve the efficacy of current therapeutic options, limit undesirable side effects and help to overcome resistance mechanisms deployed by the cells.
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Naturally Derived Biocompatible Photoinitiators for 3D Printing
… due to their migration effect. Therefore, natural photoinitiators have drawn tremendous research interest due to their known bioactivities and nature-derived origin. In this regard, this thesis mainly concentrates on 1) the development of naturally occurring photoinitiators demonstrating …
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Naturally Derived Biocompatible Photoinitiators for 3D Printing
… due to their migration effect. Therefore, natural photoinitiators have drawn tremendous research interest due to their known bioactivities and nature-derived origin. In this regard, this thesis mainly concentrates on 1) the development of naturally occurring photoinitiators demonstrating …
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An investigation into the mode of action of the anthelmintic emodepside: a molecular, pharmacological and electrophysiological characterisation
… in the mechanism of action of emodepside. The natural compound from which emodepside is derived (PF1022A) has been shown to bind the Haemonchus contortus receptor latrophilin receptor HC110R (Saeger et al 2001). Caenorhabditis elegans have latrophilin homologues, lat-1 and lat-2. Targeting of …
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Bionomy and host plant finding in oil collecting bees
… M. fulvipes, and (iv) the specific cues (scent compounds) mediating the interaction between Lysimachia and Macropis. I also tested whether cues mediating the Lysimachia-Macropis interaction may be important for other oil plants and oil bees. The bees started to hatch in the flight cage when a …
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CHEMICAL APPROACHES TOWARD NEW PERSPECTIVES IN DRUG DISCOVERY: NATURAL PRODUCTS AND BIOACTIVE HITS AS AN INSPIRATION
… of this work delves into the invaluable role of natural products as intrinsically interesting compounds and as a foundation for drug discovery. Natural products have been a cornerstone in the development of therapeutics for millennia, with their roots deeply embedded in traditional medicine. Even …
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Lipid Nanoparticles as Tools for the Administration of Active Natural Products Aimed to the Treatment of Nervous System Disorders
… effort to develop innovative therapies based on natural compounds, as old synthetic drugs cause numerous side effects. Curcumin (CUR) and astaxanthin (AST) are two natural antioxidants that possess therapeutic properties for the treatment of AD, although they show poor biovailability due to their …