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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Natural Products Chemistry"”.
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Marine Natural Products Chemistry of a Caribbean Tunicate and a Palau Sponge
Finally, new bromotyrosine-derived metabolites of the spirocyclohexadiene-isoxazoline class, named subereamides, have been isolated from the Palau sponge Suberea laboutei along with known psammaplysins A, B and D, and ceratinamide B. In addition, a new cytotoxic dibromotyramine derivative, …
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Natural Products Chemistry of Leads Acting on MRSA, HCV, Malaria, and Depression Disorders
… to Gordon Cragg, former director of the natural products branch of the NCI, ″Nature has produced wonderfully complex molecules that no synthetic chemist could ever dream up.″ Moreover, he emphasized that over 60% of cancer therapeutics have been derived from nature whether directly …
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Silylation as a Protecting Method During Grignard Reactions: A New Synthesis of Olivetol.
In recent years the study of the chemistry of Cannabis sativa, Cannabis indica and other varieties of plants, both foreign and domestic, more commonly known as marihuana, and its flower extract, the oil of hashish, has led to many new and unique syntheses of their respective substituents.The …
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Cascade Approaches to Polycyclic Natural Products
… syntheses of molecules in two different areas of natural products chemistry: the polyphenolic compounds dalesconols A and B and the coccinellid alkaloids psylloborine A, isopsylloborine A, and related monomeric structures. While polyphenols and alkaloids generally have little in common, the …
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Isolation and Structure Elucidation of Antiproliferative Natural Products from Madagascar
As part of an ongoing search for bioactive natural products from the endemic rainforests and surrounding ocean in Madagascar, a total of four extracts were comprehensively studied and were found to contain novel and/or bioactive compounds. The following dissertation discusses the isolation, …
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A Phytochemical Analysis of Secondary Metabolites in Eupatorium Serotinum
<p>Phytochemistry, a subset of Natural Products Chemistry, studies chemically derived products from natural substances. Advances in this field have important applications in medicinal research due to the distinctive and unique properties of natural compounds. All metabolites are produced from the …
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The Phytochemistry of Selected Ancistrocladus and Monsonia Species and their Anti-Pancreatic Cancer and Nrf2 Activator Properties
Fifteen naphthylisoquinoline (NIQ) alkaloids including four new compounds, the 5,8'-coupled ancistroyafungines A-C, and the 5,1'-linked ancistroyafungine D, as well as eleven known NIQs were isolated from the stem bark of an unidentified Ancistrocladus (Ancistrocladaceae) liana recently discovered …
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Proteomic Evaluation and Cytotoxicity of Red Maple (Acer rubrum) Leaves
… the first peoples. Commercially, its well-known products include maple syrup and high-quality lumber. The potential medicinal benefits of phenolic compounds extracted from the red maple plant, such as glucitol-core containing gallotannins, include antioxidant, and antiglycation effects as well as …
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A unified strategy for penostatin (Bio)synthesis and forays in computational chemistry
… endeavors in the fields of synthetic organic and natural products chemistry. Nuclear magnetic resonance (NMR) spectroscopy is unarguably the single most powerful spectroscopic tool for this task; however, the unambiguous assignment of these structural properties via spectroscopic data alone is …
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Altering the Regiospecificity of C6 Indole Prenyltransferase Enzymes Towards Drug Development
… are late-stage tailoring enzymes that modify natural products. PTs catalyze the attachment of prenyl moieties to natural product acceptors using pyrophosphate donors. This prenyl modification in small molecules leads to changes in structural and biological activities. Understanding the …
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The Structural Characterization and Bioactivity Assessment of Nonspecific Lipid Transfer Protein 1 (nsLTP1) from Caraway (Carum Carvi) Seeds
<p><strong>Background</strong>: Carum carvi (caraway) of the Apiaceae family has been used in many cultures as a cooking spice and part of the traditional medicine. Previous reports primarily focus on the medicinal properties of caraway seed essential oil and the whole seeds extract. However, no …
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Cytotoxic Activity of Non-Specific Lipid Transfer Protein (nsLTP1) and Proteomic Evaluation of Heparin-Binding Proteins from Ajwain (Trachyspermum ammi) Seeds
<p>Trachyspermum ammi, commonly known as ajwain, is a member of the Apiaceae family. It is a therapeutic herbal spice with diverse pharmacological properties, used in traditional medicine for various ailments. However, all previous studies were conducted using small molecule extracts, leaving the …
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Evaluation of Anthelmintic Properties and Toxicity of Pure Compounds Isolated from Dalea Spp (Plantae, Fabaceae)
Infecting upwards of a billion people worldwide, hookworm is one of the most prevalent parasitic infections affecting the world today. Those infected experience hookworm disease, characterized by severe anemia, which can lead to malnutrition, low birth weights, and physical and mental impairments. …
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Synthesis of Marine Chemicals and Derivatives as Potential Anti-Cancer Drugs.
<p>Two natural marine compounds, 3-bromo-4,5-dihydroxybenzaldehyde <b>2</b> and 2,3-dibromo-4,5-dihydroxybenzaldehyde <b>5</b> together with two novel derivatives, 3-bromo-5-(tert-butyl-dimethyl-silanyloxy)-4-hydroxybenzaldehyde <b>3</b> and 1-bromo-2,3-dimethoxy-5-nitrooxy-methylbenzene <b>9</b>, …
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Isolation and characterization of African marine natural products and repositioning of the natural product antibiotic fusidic acid and privileged benzimidazole scaffold for tuberculosis and malaria
… and/or cure diseases. A greater number of these natural products have not progressed to the latter stages of development as drugs largely due to the drawbacks of toxicity, limited supply, growing concerns to conserve terrestrial and marine ecosystems and their biodiversity, which impedes sample …
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Development of Tools to Assess the Effects of Lunasin on Normal Development and Tumor Progression in Drosophila Melanogaster
<p>Soy contains many bioactive molecules known to elicit anti-cancer effects. One such peptide, Lunasin, has been shown to selectively act on newly transformed cells while having no cytotoxic effect on non-tumorigenic or established cancer cell lines. In this study we attempt to understand the …
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Conformationally-Controlled Late-Stage Modifications for SAR Studies of the C-3-Glcp Moiety of Ipomoeassin F
… mechanism of action of this potent and complex natural product is still not fully understood. The α,β-unsaturated esters of the glucosyl moiety have been shown to be vital for the overall cytotoxicity of ipomoeassin F. Nevertheless, the importance of the tigloyl ester of the glucosyl moiety is …
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An Evaluation of the Medicinal Plants of Andros Island, Bahamas
… ethnobotanical opportunities to research natural products and phytomedicinals will slowly decrease. Populations that utilize plants and plant extracts need a reliable means of identifying species for safety and efficacy. Using the <em>rbcLmatK</em> gene coding regions, DNA barcoding can be …
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Development and Evaluation of Therapeutics in the Setting of Radiation Injury
<p>The possibility of an incident involving radiation exposure is at the forefront of public attention in the current global environment. With a greater number of entities possessing nuclear weapons and increased demand for nuclear power, the concern for uncontained exposure to radiation is …
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