Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Natural Product Drug Discovery"”.
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Natural product chemistry in drug discovery
This thesis examines two interrelated aspects of natural product research: the discovery and biological evaluation of plant-derived specialized metabolites as potential drug leads, and the verification of their botanical sources to ensure chemical and taxonomic accuracy. It comprises three …
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Studies of Bioactive Natural Products and Mechanism-Based Bioassays
… were prepared semisynthetically from the natural product, tested for their bioactivity, and their structure-activity dependence was observed. Bioassay guided-fractionation of an extract of a <i>Tuemoya</i> sp. green alga, using an assay for inhibitors of the enzyme Tie2 kinase, afforded a …
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Screening of South African marine filamentous actinobacteria for antitubercular compounds
Multidrug-resistant tuberculosis (MDR-TB) is a rampant problem across the globe, perpetuated by the current antimicrobial resistance challenge. To lift the burden, novel antitubercular drugs are needed to treat TB more effectively. The filamentous actinobacteria are a viable source of potential …
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Antimicrobial Producing Bacteria as Agents of Microbial Population Dynamics
… with the increasing pace of emergence of drug resistant pathogens (MRSA, XDR-TB, etc.). Modification of existing antibiotics with the additions of side chains or other chemical groups and genomics based drug targeting have been the preferred method of drug development at the corporate …