Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Natural Product Chemistry"”.
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Natural product chemistry in drug discovery
This thesis examines two interrelated aspects of natural product research: the discovery and biological evaluation of plant-derived specialized metabolites as potential drug leads, and the verification of their botanical sources to ensure chemical and taxonomic accuracy. It comprises three …
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Mechanisms of Flavin-Dependent Monooxygenases Involved in Natural Product Chemistry
Natural products are secondary metabolites produced by plants and microorganisms that often possess medicinal properties and are implicated in organismal defense. Drawbacks to utilizing natural products in the pharmaceutical industry are difficulties with isolation from biological sources and low …
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Aspects of natural product chemistry: Biosynthesis, structure elucidation and HSCCC/MBI/FABMS
The structure and biosynthesis of cremeomycin, a novel cytotoxic antibiotic from Streptomyces cremeus NRRL 3241, were established. Cremeomycin was found to be 3-diazo-4-methoxycyclohexa-4,6-dien-2-one carboxylic acid by X-ray crystallography. Through the intermediacy of 4-methoxysalicylic acid, …
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Investigation of Specialized Metabolites in Apicomplexan Parasite Life Cycles
… polyketide synthase (PKS) with unknown resultant products. Together, this work provides the basis for understanding how specialized metabolites within the mosquito microbiome affect the Plasmodium parasite transmission capacity while also investigating an underexplored area of natural product …
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Isolation and Structural Elucidation of Compounds from Natural Products
… group's work to identify new compounds from natural products as a part of the International Cooperative Biodiversity Group (ICBG) program and in collaboration with the Institute for Hepatitis and Virus Research (IHVR), the two plants Neoharmsia baronii and Lopholaena cneorifolia were studied …
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Antimycobacterial activity of the red algae gelidium pristoides, plocamium corallorhiza and polysiphonia virgata
… and HIV-coinfection. In the process, natural product chemistry continues to play an important role in the search for new compounds to treat tuberculosis. Terrestrial plants have been investigated for antimycobacterial activity, while marine plants are yet to receive as much attention. …
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Ancient Triassic Halite as a novel source of antibiotic chemical diversity
… Kilroot Salt Mine, as a reservoir of unexplored natural product chemistry with antimicrobial activity against the clinically relevant ESKAPE pathogens. The capacity of haloarchaea to modulate bacterial quorum sensing via the production of cross-domain induction and inhibitory compounds were also …
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NOVEL MICROTUBULE TARGETING AGENTS: SYNTHESIS AND STRUCTURAL DETERMINATION OF THEIR INTERACTIONS
… 2.1 focuses on the functionalization of a natural product maytansinol. Maytansinoids represent a successful class of natural and semisynthetic tubulin binders, known for their potent cytotoxic activity. Their wider application as cytotoxins and chemical probes to study tubulin dynamics was …
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Towards the Structural Elucidation and Total Synthesis of Hemicalide: Assignment of the C29-C46 Region
Marine natural products are a known source of novel bioactive compounds. However, in many cases, low isolation yields and lack of full structural information necessitate total synthesis to achieve their structural elucidation, and produce sufficient material for biological studies. This thesis …