Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Natural Killer T cells"”.
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Delineating The Immunometabolism Of Human Invariant Natural Killer T Cells
Invariant natural killer T (iNKT) cells comprise a unique subset of T lymphocytes that possess innate-like functional features and are primed for activation. iNKT cells exert robust anti-tumor cytotoxicity through both direct mechanisms and by modulation of other immune populations. However, the …
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Immuno-modulatory functions of CD1d-restricted natural killer T cells
… of non-conventional T lymphocytes, called natural killer T (NKT) cells. NKT cells have many unique features; such as recognition of glycolipids presented by CD1d, expression of NK receptors and rapid production of large amounts of cytokines, such as IL-4 and IFN-gamma,?upon activation. This …
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Characterisation of the immunomodulatory properties of human natural killer T cells
Invariant natural killer (iNKT) cells are a small subset of innate cells which express an invariant T cell receptor and NK surface molecules and recognize glycolipid antigen presented by CD1. iNKT cells have shown potent anti-tumour properties when stimulated with the iNKT cell agonist …
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Structure-Activity Studies of Glycosphingolipids as Antigens of Natural Killer T Cells
… components of the plasma membrane of eukaryotic cells. They serve in many regulatory capacities and have antigenic properties towards natural killer T (NKT) cells of the innate immune system. Critical to the recognition of glycosylceramides by NKT cells are antigen presenting cells (APC), such as …
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Uncovering Novel Mechanism of Immune Modulation of Invariant Natural Killer T Cells By Liposomal Α-Galactosylceramide
<p>Invariant Natural Killer T cells (iNK-T cells) are a powerful regulatory immune cell that can recruit both innate and adaptive immune cells. Unlike conventional T cells (CD4<sup>+ </sup>and CD8α<sup>+</sup>), they recognize glycolipid antigens via the MHC-class-I like molecule, CD1d. A …
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Cord Blood-Derived Invariant Natural Killer T Cells as a Platform for Allogeneic Chimeric Antigen Receptor Cell Therapy
<p>Chimeric antigen receptor (CAR) T cells have revolutionized the treatment of hematopoietic malignancies achieving >50% complete response rates in numerous refractory/relapsed B cell malignancies. However, there are challenges that hinder CAR-T efficacy and bar the broader use of this therapy in …
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Defining The Role of Il-15 Trans-Presentation By Distinct Cell-Types During The Development and Homeostasis of Natural Killer and Invariant Natural Killer T Cells
… functions displayed by NK and iNKT cells have highlighted their importance as key lymphocytes involved in innate and adaptive immunity. Therefore, understanding the dynamics influencing the generation of NK and iNKT cells is extremely important. IL-15 has been shown to provide a …
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Characterization of Immune Cell Populations in White Adipose Tissue of Wild Type and Bovine Growth Hormone Transgenic Mice
… other cell types, including a variety of immune cells such as macrophages, T cells, Natural Killer T cells (NK), and depot specific differences in cellular composition and endocrine output. Growth hormone (GH) has been shown to impact immune function as well as adiposity. The immune cell …
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CD1d restricted NKT cells in regulation of pathogenic autoimmunity
… (AIA) – models for RA. A sub-population of T cells, termed natural killer T cells (NKT), have been suggested as having immunoregulatory features in pathogenic autoimmunity. How NKT cells are activated to perform this regulation and by which functional pathways they act is not completely …
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Investigating The Role of Il-10 Producing Nkt Cells In Prevention of Graft Versus Host Disease
… organ damage mediated by dysregulated donor T cells. Preclinical studies have shown invariant natural killer T cells (iNKT) cells can prevent GVHD while preserving GVL. iNKT cells are unconventional T cells which recognize glycolipid antigens presented in the context of CD1d. Upon activation, …
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The Role of NKT Cells in Immune Evasion of Liver Metastases Arising from Intraocular Tumors
… Here, we examine the interplay between liver NKT cells and NK cells in resistance to liver metastases from intraocular melanomas. NKT cell-deficient CD1d-/- mice and WT C57BL/6 mice treated with anti-CD1d antibody developed significantly fewer liver metastases than WT mice following either …
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Staphylococcal Enterotoxin B-Induced Acute Lung Injury:Mechanism and Treatment of Disease
… on the age of patients. The role of activated T cells and failure in capillaries of the lungs has been demonstrated in ALI; however the detailed mechanism of disease remains unclear. This study offers a better understanding of the mechanism of Staphylococcal Enterotoxin B (SEB)-induced acute lung …
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The impacts of psychological stress on innate-like invariant T cell survival, phenotype, and function
… of innate-like T lymphocytes including invariant natural killer T (iNKT) and mucosa-associated invariant T (MAIT) cells, which participate in early host defense against pathogens and tumors, remains poorly understood. In this thesis, I leveraged multiple established methods with which to induce …