Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 80 for “"Natural Killer (NK) cells"”.
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The role of the cytolytic mediators, granulysin and perforin, in tuberculosis
… to an intact Type l (Th1) cytokine pathway. Natural killer (NK) cells and cytolytic T-cells (CTL) are essential components of protective immunity against tuberculosis (TB) and mediate granule-dependent killing of infected cells. Granulysin, an antimicrobial protein, and perforin, a …
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ΔΙΑΤΑΡΑΧΕΣ ΤΩΝ Τ-ΛΕΜΦΟΚΥΤΤΑΡΙΚΩΝ ΥΠΟΠΛΗΘΥΣΜΩΝ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΜΕΓΑΛΟΒΛΑΣΤΙΚΗ ΑΝΑΙΜΙΑ
… PATIENTS. THE RATIO OF HELPER TO SUPPRESSOR T-CELLS IN PATIENTS WITH PERNICIOUS ANEMIA WAS SIGNIFICANTLY INCREASED . THIS WAS DUE MAINLY TO A DEFICIENCY OF CIRCULATING SUPPRESSOR T-CELLS AND SECONDARILY TO AN INCREASE OF HELPER T-CELLS. VITAMIN BIZ THERAPY CAN NOT RESTORE THE ABNORMAL H/S …
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Kir-Based Inhibitory Cars Overcome Car-Nk Cell Trogocytosis-Mediated Fratricide and Tumor Escape
… surface material from targeted to effector cells. Using multiple in vivo tumor models and clinical data, we report that chimeric antigen receptor (CAR) activation in natural killer (NK) cells promoted the transfer of the CAR-cognate-antigen from tumor to NK cells, resulting in (1) lower …
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The role of uterine natural killer cell-inhibition in pregnancy
Education of natural killer (NK) cells is a genetically determined process that primes NK-cell activity upon the binding of their inhibitory receptors to self-ligands. Although NK-cell education is predictable and measurable in the laboratory, its biological significance is unknown. This thesis …
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Effect of platinum chemotherapy on tumour infiltrating immune cells in metastatic ovarian cancer: Mechanistic insights and therapeutic applications
… it remains unclear to what extent innate Natural Killer (NK) cells contribute. Using two syngeneic models (UPK10 and ID8p53<sup>-/-</sup>) of metastatic ovarian cancer this thesis found that treatment with carboplatin upregulates NK cell activating receptor ligands, induced a …
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The transcriptional programme of natural killer (NK) cell functional maturation and maintenance
Natural killer (NK) cells are critical to immune surveillance against infections and cancer. Their role in immune surveillance requires that NK cells are present within tissues in a quiescent state. The functional maturation of NK cells is a tightly regulated process which is controlled by …
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NK Cells and Their Role in Disease and Cancer Treatment
Natural killer (NK) cells are a crucial part of the human immune system. They play an important role in fighting and controlling viral infections as well as killing cells that have transformed into tumors. NK cells are involved in the pathogenesis of a number of diseases and in this thesis we will …
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Ex Vivo Expanded Cord Blood Natural Killer Cells As A Novel Therapeutic For Multiple Myeloma
… in adults and, to date, is incurable. Allogeneic natural killer (NK) cells are active in various hematologic malignancies and may have a role against MM. Umbilical cord blood is a potential source for allogeneic NK cells and <em>ex vivo</em> expanded umbilical cord blood-derived NK (CB-NK) cells …
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The effects of calorie restriction and aging on natural killer cells in c57bl/6 mice
… innate immune response. This research focuses on natural killer (NK) cells in aged (22 mo) calorie restricted (CR) C57Bl/6 mice. NK cells are innate immune cells capable of killing tumor or virus-infected cells. We used flow cytometry to analyze NK cell maturation in young ad libitum (AL) fed, …
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Nonspecific Cell-Mediated Cytotoxicity in the Cat
… a chromium-51-release microcytotoxicity assay, naturally occurring cytotoxic cells were demonstrated in peripheral blood and spleens of domestic cats. Lymphocytes from blood and spleen were purified over Ficoll-Hypaque and added to uninfected, vaccinia-infected, or herpes-infected adherent …
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The Major Histocompatibility Complex (MHC) and the proteasome-ubiquitin pathway in T cell development
… for MHC-mediated antigen presentation to T cells is well established. However, the contribution of nonclassical MHC molecules, the signals evoked by the MHC-TCR interactions, the signaling role of the proteasome-mediated proteolysis, and the regulation of the proteasome-ubiquitin proteolysis …
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The role of natural killer cells in control of varicella zoster virus infection
… As with other components of the innate response, Natural Killer (NK) cells respond directly to VZV infection, and VZV is likely to use evasion strategies to modulate the immune response. This thesis explores the details of this interplay between NK cells and VZV. First, I address the hypothesis …
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Transposable elements and the regulatory logic of hematopoietic differentiation
… studies on transposable elements (TEs) as natural and engineered sources of regulatory innovation that contribute to, and aid in the investigation of, dynamic cellular processes. Toward this end, I built comprehensive genome-wide enhancer-gene maps spanning the human hematopoietic system …
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An Investigation into the Potential of Cell Therapies for Acute Myeloid Leukemia (AML) Treatment
… and human-leukocyte antigen (HLA) matching. Natural killer (NK) cells and gamma delta (γδ) T cells offer alternative effector cell options for cell therapies that do not require HLA-matching and have shown low toxicity in previous studies. In this project, we sought to evaluate FT538 induced …
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Soy Isoflavone Supplementation Does Not Alter Distribution of Circulating Lymphocytes or Natural Killer Cell Activity in Postmenopausal Women
… chronic diseases. This defense could be linked to isoflavone-induced alterations in immune function. However, to date, no study has examined the effect of soy isoflavone supplementation on human immunity in vivo. Establishing whether isoflavones affect immunity in aging adults is …
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MICROGRAVITY NEGATIVELY AFFECTS DNA DAMAGE REPAIR AND THE ANTI-LEUKEMIC FUNCTION OF HUMAN NATURAL KILLER CELLS
… shown that exposure of human hematopoietic stem cells (HSC) to mission-relevant doses of accelerated high-energy protons (the primary component of SEPs) and high atomic number and energy (HZE) ions (the high-energy nuclei component of GCR) induces DNA damage, alters HSC function/differentiative …
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Modulation of Ly49A+ Natural Killer Cell Licensing by Major Histocompatibility Complex Class I Alleles
Natural killer: NK) cells are innate immune lymphocytes that react to cells lacking self-MHC: major histocompatibility complex) class I molecules, such as transformed or virally infected host cells and allogeneic bone marrow. This reactivity is mediated by inhibitory receptors for MHC class I that …
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Innate memory to bacterial infection
The innate lymphoid cells (ILCs) ILC1, ILC2, and ILC3, which also includes the natural killer (NK) cells are important regulators and first line responder during pathogen invasion. The role of ILCs was evaluated using FACS sorting, cytokine production and surface markers analysis, cell depletion, …
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Ανάλυση λεμφοκυτταρικών υποπληθυσμών στην χρόνια λεμφογενή λευχαιμία με χρήση μονοκλωνικών αντισωμάτων: Προγνωστική σημασία ανοσολογικών παραμέτρων
… the disease. The ratio of helper to supressor T cells (CD4/CD8), the proportion of circulating natural killer (nk) cells and the nk activity were significantly low in clinical stage B and C patients. Patients with low H/S ratio (<1.1), irrespective of clinical stage, had a mean amount of …
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Modulation of immune responses by human paraininfluenza virus
… infection generated potent and mature dendritic cells (DCs). However, unlike influenza A generated DCs, allogeneic human mixed leukocytes (MLR) failed to proliferate to HPIV3 generated DCs. Conversely pur3ed CD3+T cells were capable of expanding to these DCs. Further investigation revealed that …
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