Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 211 for “"Natural Killer"”.
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Circulating Natural Killer Cells and Natural Killer Receptor Positive T Cells In Patients with Hepatitis C
… the virus and develop chronic liver disease. Natural killer (NK) cells are thought to mediate immunity against viruses. They can lyse virus infected cells and release anti-viral cytokines. The roles of NK cells and natural killer receptor positive (NKR+) T cells in immunity agamst HCV is …
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Natural Killer Cell Responses to Human Cytomegalovirus
… understood. To evade the potent and diverse natural killer (NK) cell mediated- effector functions, HCMV encodes an array of immunoevasins and perturbs the NK cell receptor repertoire with considerable inter-and intra-individual heterogeneity. While certain NK subsets expand in response to …
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Characterization of cord blood natural killer cells: implications for cord blood transplantation and insights into natural killer cell differentiation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Licensed to kill. Towards Natural Killer cell immunotherapy.
Contains fulltext : 87167.pdf (Publisher’s version ) (Open Access)
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Natural Killer Cell Recruitment and Activation Following Orthopoxviral Infection
… host responses for resistance and survival. Natural killer: NK) cells provide an essential innate response to infection through direct lysis of infected cells and cytokine production. The innate anti-viral response following infection is associated with NK cell population expansion in …
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Immunogenetic regulation of Natural Killer cell function in pregnancy
… to peripheral NK cells, uNK cells express Natural Killer receptors (NKRs) that engage MHC class I molecules. Evidence from human genetic association studies suggests that, in the presence of allogeneic cognate paternal MHC class I ligands, inhibitory uterine NKRs are associated with …
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Natural Killer Cell Responses in Chronic Hepatitis C Virus Infection
… T cells contribute to disease pathogenesis. Natural killer (NK) cells constitute the major innate immune cell population in the liver. They are capable of producing cytokines and utilize multiple mechanisms of cytotoxicity. The high prevalence of NK cells in the liver, along with their …
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Delineating The Immunometabolism Of Human Invariant Natural Killer T Cells
Invariant natural killer T (iNKT) cells comprise a unique subset of T lymphocytes that possess innate-like functional features and are primed for activation. iNKT cells exert robust anti-tumor cytotoxicity through both direct mechanisms and by modulation of other immune populations. However, the …
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Immuno-modulatory functions of CD1d-restricted natural killer T cells
… of non-conventional T lymphocytes, called natural killer T (NKT) cells. NKT cells have many unique features; such as recognition of glycolipids presented by CD1d, expression of NK receptors and rapid production of large amounts of cytokines, such as IL-4 and IFN-gamma,?upon activation. This …
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Natural killer T cell subsets and regulation of autoimmune diabetes
This thesis is focused on natural killer (NK) T cells. NKT cells recognize lipids and glycolipids, rather than peptides, in the contents of the antigen presenting molecule CD1d. NKT cells have a surface phenotype reminiscent of memory cells, and have been shown to rapidly produce large amounts of …
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The elaborate interplay of natural killer cells and vaccinia virus
… little known about the relationship between natural killer (NK) cells and VACV. Previous studies showed that during VACV infection, NK cells proliferate, are activated, limit viral replication, kill VACV-infected cells and display memory-like qualities. However, how NK cells recognise and …
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The role of uterine natural killer cell-inhibition in pregnancy
Education of natural killer (NK) cells is a genetically determined process that primes NK-cell activity upon the binding of their inhibitory receptors to self-ligands. Although NK-cell education is predictable and measurable in the laboratory, its biological significance is unknown. This thesis …
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Defining The Role of Il-15 Trans-Presentation By Distinct Cell-Types During The Development and Homeostasis of Natural Killer and Invariant Natural Killer T Cells
The immuno-regulatory functions displayed by NK and iNKT cells have highlighted their importance as key lymphocytes involved in innate and adaptive immunity. Therefore, understanding the dynamics influencing the generation of NK and iNKT cells is extremely important. IL-15 has been shown to provide …
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Characterisation of the immunomodulatory properties of human natural killer T cells
Invariant natural killer (iNKT) cells are a small subset of innate cells which express an invariant T cell receptor and NK surface molecules and recognize glycolipid antigen presented by CD1. iNKT cells have shown potent anti-tumour properties when stimulated with the iNKT cell agonist …
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Alternate pathways of cytotoxic T lymphocyte and natural killer cell activation
CD44 is a transmembrane glycoprotein found on a variety of cells including those of myeloid and lymphoid origin. CD44 is highly conserved among various species and is involved in the homing of lymphocytes and monocytes to lymph nodes, Peyer's patches, and sites of inflammation. In the present …
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ROLE OF NATURAL KILLER CELLS IN THE PATHOGENESIS OF PRIMARY BILIARY CHOLANGITIS
… recent studies demonstrated a central role for Natural Killer (NK) cells in the destruction of BECs, a deep and comprehensive characterization of these cells in PBC patients is still lacking, especially in those patients that fails UDCA treatment. Methodology: In this project, we characterized …
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Development Of Thymic Natural Killer Cells From Double Negative 1 Thymocyte Precursors
… in defining the specificity and function of natural killer: NK) cells, their differentiation has not been fully elucidated. Previous studies of thymocyte development <italic> in vitro</italic> indicate that double negative: CD4<super>&minus</super>CD8<super>&minus</super>, DN) thymocytes can …
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A License to Kill: Understanding Natural Killer Cell Licensing to Fight Cancer
<p>Natural killer (NK) cell education is an essential developmental process for NK cell effector function, that renders some NK cells “licensed” and others “unlicensed” (with heightened or lowered effector function potential, respectively) against tumor and targets lacking self-molecules. However, …
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Study of Natural Killer Cells and Their Therapeutic Role in Pediatric Cancer
… cells are known to play an important role in the natural defense against viral infections and tumor immune surveillance. Through complex interactions between NK cell receptors and target cell ligands, transformed or unhealthy cells are identified and rapidly eliminated. NK cells have been used for …
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