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Showing 1 to 19 of 19 for “"Natriuretic peptides"”.
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Natriuretic Peptides and the Microcirkulation in Heart Failure Patients
… and better diagnostic tools, e.g. biomarkers of natriuretic peptides, the morbidity and mortality due to this disease are still prominent. HF leads to vascular dysfunction in the general circulation but the interpretation of this is not clear. In our studies we have focussed on defining …
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Plant natriuretic peptides - elucidation of the mechanisms of action
… antibodies generated against vertebrate atrial natriuretic peptides (ANPs). Functional characterization of these immunoanalogues, referred to as immunoreactive plant natriuretic peptides (irPNPs) or plant natriuretic peptides (PNPs), has shown that they play important roles in a number of …
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Fluid retention in congestive heart failure-the role of natriuretic peptides and arginine vasopressin
… heart failure (CHF). The role played by atrial natriuretic factor (ANF), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP) and arginine vasopressin (AVP) in CHF is not fully understood. Studies were done in 300days old male normal and cardiomyopathic hamsters with moderate CHF. …
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Acute heart failure: Scottish temporal trends in hospitalisation, outcomes and clinical application of natriuretic peptides
… failure is essential to improving outcomes and natriuretic peptides (NPs) are the recommended biomarkers for diagnosis of AHF. NP concentrations are known to be altered by patient factors, such as age, renal impairment and arrhythmia, which are common in populations with heart failure. The …
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Biomarcadores relevantes para diagnóstico precoce e prevenção de doenças cardiovasculares.
… A2 , apolipoprotein AI / apolipoprotein B , natriuretic peptides and myeloperoxidase are biomarkers nontraditional whose predictive power and clinical application are under discuss ion . CRP, homocysteine , Lp (a) Lp - PLA2 and MPO act in pathophysiological mechanisms stimulating the …
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Regulation of natriuretic peptide system activation:effects of spontaneous natriuretic peptide mutations and identification of novel natriuretic peptide receptor phosphorylation sites.
… that mediate the physiologic effects of natriuretic peptides, including reduction of blood pressure and blood volume, stimulation of long bone growth, and regulation of cardiac size. Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) signal through GC-A while C-type …
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UNVEILING NOVEL CARDIOPROTECTIVE EFFECTS OF GYY4137, A SLOW-RELEASING HYDROGEN SULFIDE DONOR, AND THEIR RELATIONSHIP TO NEUROHORMONAL MODULATION AND MICRORNA PROFILES DURING MYOCARDIAL ISCHEMIC INJURY.
… treatment with GYY increased levels of the natriuretic peptides ANP and BNP in association with enhanced cyclic GMP levels. In addition, GYY treatment had effect on the microRNA profiles. In conclusion, GYY preserves cardiac function, attenuates adverse remodeling and may exert post-ischemic …
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Physiological and cellular characterization of a plant natriuretic peptide
… by antibodies against vertebrate atrial natriuretic peptides (ANPs). It has been demonstrated that a recombinant Arabidopsis thaliana natriuretic peptide analogue (AtPNP-A) molecule can induce osmoticumdependent water uptake into protoplast at nanomolar concentrations thus affecting cell …
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EFFECTS OF DAPAGLIFLOZIN ON EXERCISE CAPACITY, RESPIRATORY FUNCTION, BIOMARKERS, SLEEP APNEA, AND LEFT VENTRICULAR REMODELING IN PATIENTS WITH HEART FAILURE: A PROSPECTIVE, SINGLE CENTER, NON RANDOMIZED STUDY
… increased significantly, while peakVO2, natriuretic peptides, and spirometry remained unchanged. DLCO and its subcomponents (Dm and Vcap) were stable, yet a significant reduction in circulating proSP-B was observed, suggesting improved alveolar-capillary membrane integrity. Central sleep …
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The Aging-Induced Decline in Beige Adipose Tissue Development
… age: the de novo lipogenesis (DNL) pathway and natriuretic peptides. In Chapter 3, we follow-up on hypotheses from Chapter 2 and assess the aged environment using transplantation experiments and examine two candidate genes, Pdgfrl and Npr3, to further elucidate their mechanisms. I conclude in …
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Assessment and Treatment of Impaired Insulin- Secretion and Action in Type 2 Diabetes
… caused fluid retention and increased levels of natriuretic peptides suggesting increased cardiac load (Papers II & IV). While pioglitazone improved insulin sensitivity and lipids, insulin glargine resulted in improved β-cell function (Paper IV). Pioglitazone also caused an increase in eye …
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Secondary and Tertiary Prevention at Different Stages in the Development of Heart Failure
… heart disease. Part A is based on the Natriuretic Peptides in the Community 2 study, which had a prospective cross-sectional design. It compared the utility of NT-proBNP with electrocardiography for the detection of left ventricular hypertrophy among patients with type 2 diabetes …
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An investigation of the role of Arabidopsis thaliana plant natriuretic peptide in planta
… brassinosteroids and peptide hormones. Plant natriuretic peptides have been proposed to be peptide hormones involved in maintaining water and ion homeostasis in plants. Evidence for this has been provided by studies of plant responses to exogenous natriuretic peptide treatment, however a …
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Hypergravitationsinduzierte Effekte auf cGMP-Konzentration humaner Melanozyten und Melanomzellen
… oxide donor and of the membrane isoforms by natriuretic peptides were not changed by hypergravity in comparison to 1g controls. Thus, the hypergravity-induced alteration in cGMP levels was due to a stimulation of the cGMP export into the extracellular space. On the other hand, cyclic AMP …
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Simple Tests for Assessing Kidney and Cardiovascular Function in Chromic Kidney Disease Patients (Stages 2, 3 and 4)
… stiffness, heart rate variability (HRV) and natriuretic peptides (NT- proBNP and NT-proCNP) were measured in a cohort of CKD patients of stages 2,3 and 4. The primary aim however of the thesis was to measure the Kidney Functional Reserve (KFR) of CKD3 and CKD4 patients as it has been thought …
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Preoperative testing and medical therapy intervention to improve perioperative outcomes in noncardiac surgical patients.
… The first objective was to study the approach of natriuretic peptide-directed medical therapy in non-surgical patients to inform development of a preoperative protocol in surgical patients through a systematic review. The second objective was to conduct systematic review on exercise therapy in …
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Neurohormonal and inflammatory markers in valvular heart disease
… Numerous studies demonstrate that increased natriuretic peptide plasma levels, including atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP) and amino-terminal BNP (N-BNP) reflect left ventricular dysfunction, correlate with symptoms of cardiac failure and are independent …
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Endogenous atrial natriuretic factor and airway control
… investigating the role of endogenous atrial natriuretic factor (ANF) in the modulation of airway calibre and bronchial hyperresponsiveness in humans under normal physiological conditions. Two approaches are used. One approach examines the diurnal variation of endogenous ANF and its effect on …
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The application of the N-terminal fragment of pro hormone brain natriuretic peptide (NT proBNP) in cardiac disease risk assessment
… peptide that is derived from proBNP a cardiac natriuretic peptide (NP), which is measured in plasma to assist with management of cardiac related conditions. The first aim of this study was to examine the biological variation (BV) of NT proBNP and to calculate its reference change value (RCV) in …