Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Nasopharyngeal Carcinoma"”.
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The Role of MicroRNAs in Human Nasopharyngeal Carcinoma
… in locoregional control in the contemporary era, nasopharyngeal carcinoma (NPC) patients still suffer from a significant risk of distant metastasis (DM). Thus, developing methods to better identify and treat NPC patients at risk of DM is of paramount importance. MicroRNAs (miRNAs) have been shown …
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Genetic and gene expression analysis of nasopharyngeal carcinoma (NPC)
… and differential RNA expression profiles in Nasopharyngeal carcinoma (NPC). Gene expression profiles identified a large number of differentially regulated genes involved in diverse functional processes, while genetic analysis detected extensive genomic abnormalities including large and small, …
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Clinical pharmacokinetics of low dose paclitaxel in Asian patients with nasopharyngeal carcinoma
… paclitaxel in Asian patients with WHO Stage III nasopharyngeal carcinoma treated with a chemo-radiation regimen were determined and correlated with subjecta??s demographics, clinical parameters, outcome with the intent of optimizing therapeutic benefit to risk ratio in clinical use. Chemotherapy, …
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Studies of the anti-cancer potential of flavonoids in Human Nasopharyngeal carcinoma cells
… two flavonoids namely luteolin and quercetin on nasopharyngeal carcinoma (NPC) using two NPC cell lines, HK1 and CNE2. We first identified the mechanisms leading to quercetin-mediated cell cycle arrest in NPC cells. Quercetin was able to inhibit E2F-1 transcriptional activity, thus preventing the …
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Treatment outcomes of Epstein-Barr virus associated nasopharyngeal carcinoma with three-dimensional conformal radiotherapy: A retrospective review
… outcomes of Epstein-Barr virus (EBV) associated nasopharyngeal carcinoma (NPC) largely comes from endemic regions. There is limited literature available regarding the epidemiology and treatment outcomes of EBV associated NPC in South Africa. Aim: The primary aim of the study was to determine …
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Η ανοσοθεραπεία ως θεραπεία πρώτης γραμμής για υποτροπιάζον ή μεταστατικό ρινοφαρυγγικό καρκίνωμα: Μια αφηγηματική ανασκόπηση των διαθέσιμων δεδομένων / Immunotherapy as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma: A narrative review of the evidence
Το ρινοφαρυγγικό καρκίνωμα (NPC) αποτελεί μια βιολογικά διακριτή κακοήθεια της κεφαλής και του τραχήλου, με ισχυρή συσχέτιση με τον ιό Epstein–Barr (EBV), έντονη γεωγραφική κατανομή και ιδιαίτερα ανοσολογικά χαρακτηριστικά. Επειδή συχνά διαγιγνώσκεται σε προχωρημένο στάδιο, σημαντικό ποσοστό …
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TREATMENT AND MODELING OF EPSTEIN-BARR VIRUS POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDER
… various diseases such as Burkitt’s lymphoma, nasopharyngeal carcinoma, and post-transplant lymphoproliferative disorder (PTLD). In all of these diseases, the expression of Epstein-Barr virus nuclear antigen 1 (EBNA-1) is common and therefore this viral protein represents a possible therapeutic …
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The Effect of Modeled Microgravity and Radiation on Epstein-Barr Virus in a Modeled Spaceflight System
… Burkitt’s lymphoma, Hodgkin’s lymphoma, nasopharyngeal carcinoma, and post-transplant lymphoproliferative disorder, among others. EBV is known to reactivate during spaceflight, increasing to levels ten times those observed pre-and post-flight. Although stress has been shown to increase …
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EBV-Associated Gastric Cancer: From Initial Infection to Unique Therapeutic Approaches
… and epithelial cancers. Specifically, gastric carcinoma, nasopharyngeal carcinoma, and lymphoepithelioma-like carcinoma which occurs across multiple sites in the body, most notably, in the lung. EBV-associated gastric cancer (EBVaGC) is a unique subset of gastric cancer that makes up 10% of all …
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EBV BART MicroRNAs Target Pro-apoptotic and Anti-Wnt Signaling Genes to Promote Cell Survival and Proliferation
… EBV latently infected epithelial cells, such as nasopharyngeal carcinoma (NPC) and gastric carcinoma (GaCa) cells, viral protein expression is low. In contrast, a cluster of viral microRNAs (miRNAs) called miR-BARTs is highly expressed. MiRNAs are small non-coding RNAs which regulate gene …
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CD4+ T cell recognition of Epstein-Barr virus nuclear antigen (EBNA) - 1 in the Chinese population
The current treatment of nasopharyngeal carcinoma (NPC), a tumour common in southern Chinese people, is dependent on chemo/radiosensitivity. Patients with early stages of the disease are usually chemo and radiosensitive with 5 years survival rates of 90% whereas, patients with late-stages of the …
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Uncovering functional mechanisms in cancer through integrative genomics
The genome has been called the blueprint of life for it encodes a complete set of genetic instructions that specify the precise design and timing of functional molecules (such as RNAs and proteins) responsible for carrying out all cellular processes. In recent years, the human genome, comprised of …
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CHARACTERIZATION OF HUMORAL RESPONSE TO EPSTEIN-BARR VIRUS (EBV) INFECTION AND PROTEIN KINASES INVOLVED IN VIRAL REPLICATION
… malignancies including Burkitt’s lymphoma (BL), nasopharyngeal carcinoma (NPC), Hodgkin’s lymphoma and gastric carcinoma, which account for approximately 200,000 new cases and 140,000 deaths each year worldwide. Cellular protein kinases have been reported to play a role in the viral life cycle, …