Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"Nasal epithelium"”.
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Investigation of intercellular transport and biodistribution of curcumin across the nasal epithelium in hamsters
… compounds to the brain after instillation in the nasal cavity. The exact mechanism(s) by which compound translocation from the nose to the brain occurs are unknown. Several hypothesized pathways for compound transport have been proposed and include movement through various nerves in the nasal …
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Compartmental responses of the respiratory tract to Staphylococcus aureus
… molecular patterns. The role of nasal colonisation of S. aureus has started to receive more attention. In spite of this, there are not enough studies looking at its effects on human primary nasal epithelial cells and their response to TLR ligands. The respiratory tract itself …
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The percutaneous absorption of ionisable compounds
… enhancers for peptide compounds across nasal epithelium. One potential mode of action is that CDs include these compounds, protect them from enzymic attack and thereby increase their residence time in the nasal epithelium. This study investigated the potential of CDs to protect ester …
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The structure and function of a bovine salivary protein - BSP30b
… (BSP30b) is a member of the palate, lung, and nasal epithelium clone (PLUNC) family which includes human bactericidal/permeability-increasing protein (BPI) and lipopolysaccaride binding protein (LBP). BSP30b is predominantly found in bovine saliva but its function is not understood. Although …
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Developing novel prophylactic approaches against SARS-CoV-2 infection
… that UDCA reduces ACE2 expression in the nasal epithelium in humans. Finally, I present a retrospective analysis using an independent patient cohort which identify a correlation between UDCA treatment and positive clinical outcomes following SARS-CoV-2 infection, including hospitalisation, …
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Genomic investigation into the evolution of <i>Staphylococcus aureus</i> and the micro-epidemiology of <i>Staphylococcus aureus </i>in atopic eczema
… comparison to healthy children asymptomatically nasally colonised, looking for evidence of micro-evolutionary change suggestive of adaptation to the host. Secondly by comparing isolates from a cohort of AE cases to childhood nasal carriers to characterise the population structure and genetic …
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Elucidation of the roles of PTN and ISG15 in RSV cytopathogenesis: possible biomarkers of severe disease?
… infection is restricted primarily to the airway epithelium. As such, research aimed at detecting innate immune responses of human airway epithelium to RSV is likely to yield crucial insights into the cytopathogenesis of this infection. It has previously been demonstrated that an ex‐vivo/in‐vitro …
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Studio in vitro dell'espressione di varianti del gene CFTR con ruolo patofisiologico non ancora definito
… of the CFTR transcripts, by RNA extraction from nasal epithelial cells, allows to identify new mutations and/or to define the pathogenic role of variants initially considered as polymorphisms. In this PhD study, three different mutations, identified in patients followed at the CF Center of …
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Bioadhesive Microparticles and Liposomes of Anti-Parkinson Drugs for Nasal Delivery
The nasal route is highly promising for the delivery of drugs exerting local effects in the nose or for therapeutic molecules having systemic or CNS effect. This is attributed to the fact that the nasal epithelium is highly vascularized and permeable, which ensures rapid absorption of the drug. The …