Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"Nasal Delivery"”.
-
Bioadhesive Microparticles and Liposomes of Anti-Parkinson Drugs for Nasal Delivery
The nasal route is highly promising for the delivery of drugs exerting local effects in the nose or for therapeutic molecules having systemic or CNS effect. This is attributed to the fact that the nasal epithelium is highly vascularized and permeable, which ensures rapid absorption of the drug. The …
-
Nasal delivery of peptides using powder carriers based on starch/poly(acrylic acid)
… to the disadvantages associated with parenteral delivery alternative routes of administration (buccal, nasal, pulmonal, ocular, transdermal, rectal and vaginal route) have been investigated. In the present work, the nasal route was selected as an alternative route for peptide delivery. Despite …
-
Development of a platform for nasal delivery of peptides and vaccines using powder carriers based on starch/poly(acrylic) acid
The interest in and importance of systemic drug delivery via the nasal route have expanded in recent decades since nasal administration offers an interesting alternative for the conventional oral and parenteral drug delivery routes. In this thesis, the nasal route was selected as an alternative …
-
The effect of precipitation techniques on bioadhesive microparticle characteristics
… preparing bioadhesive HPMC microparticles for nasal delivery. Aqueous gels of lactose:HPMC (1:1) were used as a model formulation, added to a precipitating solvent, and the effect of processing parameters such as stirring speed (1000-2000 rpm), needle gauge (19g, 21g and 23g), and dropping rate …
-
Development of a mucosal vaccine delivery system
Vaccine delivery systems that target the mucosal immune system carry important advantages in terms of accessibility and acceptability. Lipid based nanoparticles with and without the incorporation of bile salts were formulated by novel preparation methods in order to provide suitable immunogen …
-
Development of a novel in vitro system for nasal drug delivery development
There is currently, no ideal system for studying nasal drug delivery in vitro. The existing techniques such as the Ussing chamber and cell culture all have major disadvantages. Most importantly, none of the existing techniques accurately represent the interior of the nasal cavity, with its airflow …
-
Development of Binary Composite Solid Microparticles for Improved Intranasal Absorption of Low Permeation Drug Molecules
… introduce a novel formulation strategy for intranasal delivery of two low permeation candidates: levodopa (L-DOPA; antiparkinsonism drug) and ribavirin (RBVN; an antiviral drug). The central hypothesis states that preparation of binary composite microparticles with Pluronic® triblock copolymers …