Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Narrow-spectrum"”.
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Investigation of Narrow Spectrum Targets in Antibacterial Drug Discovery
… concerns are associated with the use of broad-spectrum antibacterial agents, including collateral eradication of beneficial bacteria from the human microbiome, the onset of antibacterial-associated infections, and continued emergence of antibacterial drug resistance. As such, a critical need …
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An investigation into the use of High-Intensity Narrow Spectrum light as a decontamination technology
… the inactivation efficacy of High-Intensity Narrow Spectrum Light (HINS-light) on a wide range of microorganisms using LED arrays that emitted intense 405-nm light. The theorised inactivation mechanism involves 405-nm stimulation of endogenous porphyrins, ultimately leading to production of …
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High energy femtosecond fiber laser at 1018 nm and high power Cherenkov radiation generation
… employed. This is the highest pulse energy with narrow spectrum at 1018 nm. For a photonic analog-to-digital conversion system operating at 1250 nm, a fiber laser system generating 4 W of femtosecond Cherenkov radiation at that wavelength was built. The characteristics of the Cherenkov radiation …
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Secure protocols for wireless availability
… MAC (IFR-MAC), and Redundancy O ffset Narrow Spectrum (RONS). SimpleMAC and IFR-MAC build on MAC protocols that utilize explicit channel coordination in control communication. SimpleMAC counters MAC-aware adversary that uses the information being exchanged at the MAC layer to perform a …
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The Effects of Insecticides on Squash Bug, its Egg Parasitoids and Pollinators in Virginia Cucurbit Production
… commonly combine the application of broad-spectrum insecticides with the frequently applied prophylactic fungicides. Broad-spectrum insecticide applications are known to have negative effects on natural enemy populations, are capable of promoting insecticide resistance, and can have …
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Development of natural and engineered bacteriophages as antimicrobials
… for both of these problems, in that they are narrow-spectrum and can be used to specifically kill target microbes without disrupting whole community structure through off-target effects. Here, various approaches to creating phage-based therapeutics are explored, including the isolation and …
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Collective dynamics of evolving populations and their strategies with application to medicine
… resistance can be significantly delayed by using narrow and ultra-narrow spectrum antibiotics to target pathogens, rather than the entire microbiome. We also develop a new strategy that involves spoofing quorum sensing channels of commu- nication, causing premature expression of virulence factors. …
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Linear and nonlinear resonance of water waves near periodic structures
… further extend to random incident waves with a narrow spectrum centered near twice the natural frequency of the trapped wave. The effects of detuning and bandwidth of the spectrum are examined. In the second part of the thesis, we study the Bragg resonance of surface water waves by (i) a line of …
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Rapeseed (Brassica napus L.) Termination and Integration of Halauxifen into Virginia Cotton (Gossypium hirsutum L.) Production
… by halauxifen. Results indicate halauxifen has a narrow spectrum of control providing adequate control (>80%) of horseweed, henbit (Lamium amplexicaule L.), and purple deadnettle (Lamium purpureum L.), while failing to control cutleaf evening-primrose (Oenothera laciniata Hill), curly dock (Rumex …
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The Discovery and Development of Thienopyrimidines as Inhibitors of Helicobacter pylori
… of a proton pump inhibitor and two broad-spectrum antibiotics such as clarithromycin and amoxicillin, is becoming less effective due to the rise of strains with resistance against these antibiotics. In the search for narrow spectrum drugs for the treatment of H. pylori infections, a …
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Investigating FDA-Approved Drugs for Treatment of Multidrug-Resistant Neisseria gonorrhoeae
… Interestingly, three extremely potent and narrow-spectrum novel candidates, itraconazole, isavuconazole, and ravuconazole, are azole antifungals, and their activities were further investigated in vitro. Of the three azoles, ravuconazole displayed the most potent activity against N. …
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Computer-Aided Drug Discovery for Helicobacter pylori
… for hit-to-lead optimization to find novel and narrow-spectrum Hp inhibitors.</p>
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Aeromonas bakteriofago KLEA5 uodegėlės baltymo gp45 tyrimai /
… gp45_N-his and gp45_C-his proteins have a narrow spectrum of activity and that they are specific only for cells of the A. veronii KR2-5 isolate. The study of the interaction of the recombinant proteins with bacterial cells showed that the proteins with depolymerase activity potentially are …
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Optimisation of 405 nm HINS-light technology for the development of patient-safe decontamination in arthroplasty surgery
… after revision surgery. 405 nm high-intensity narrow spectrum (HINS) light has been proven to reduce environmental contamination in hospital isolation rooms, and there is potential to develop this technology for application in orthopaedic surgery. Cultured rat osteoblasts were exposed to 405 nm …
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Stimulating antibiotic development by targeting virulence and facilitating natural product discovery
… possible, several new approaches have focused on narrower spectrum agents that have significant potential benefits. Antibiotics active against only one or a small group of pathogens would spare the microbiome, which may decrease the risk of secondary infections and slow the spread of resistance. …
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Metrologia dei campi di radiazioni di bassa energia
… Air Kerma rate” series (L), N10-N40 of the ISO “Narrow spectrum” series (N) and H10-H60 of the ISO “High Air-kerma rate” (H) series and two beams at 5 kV and 7.5 kV were determined by utilising X-ray spectrum measurements. The pulse-height spectra were measured using a planar high-purity …
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Biosynthetic engineering of plantazolicin natural products
… natural product that exhibits extraordinarily narrow-spectrum antibacterial activity towards the causative agent of anthrax, Bacillus anthracis. During PZN biosynthesis, a cyclodehydratase catalyzes cyclization of cysteine, serine, and threonine residues in the PZN precursor peptide (BamA) to …
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Genetically programmable pathogen sense and destroy/
… release minimum but sufficient amounts of very narrow spectrum antimicrobial proteins to control the early stages of infection before the disease becomes systemic. Therefore this system's rapid, automated and highly specific response can be helpful in reducing the occurrence of dose dependent …
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Creating effective drug discovery methods in Mycobacterium abscessus
… the focus of antibiotic discovery has been on narrow spectrum, species specific compounds, and I have focussed on developing tools in a single bacterium, Mycobacterium abscessus. M. abscessus is an emergent human pathogen which causes lung infections in those with underlying lung conditions, …
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Siderophore-Based Drug Repurposing of Platinum Anticancer Agents as Targeted Antibiotics and Investigation of Pt-Induced DNA Damage in Gram-Negative Bacteria
… has been exacerbated by the overuse of broad-spectrum antibiotics, resulting in adverse consequences such as the rapid emergence and spread of antibiotic resistance. Additionally, the use of broad-spectrum antibiotics disrupts the human microbiota, potentially leading to the onset of diseases …
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