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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Naproxen"”.
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Naproxen-induzierte Pseudoporphyrie bei Kindern mit Erkrankungen des rheumatischen Formenkreises
Bei der Naproxen-induzierten Pseudoporphyrie bei Kindern und Jugendlichen mit Erkrankungen des rheumatischen Formenkreises handelt es sich um ein Krankheitsbild, das durch Hauterscheinungen charakterisiert wird, die klinisch und histologisch nicht von einer Porphyria cutanea tarda zu unterscheiden …
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Design, synthesis, and evaluation of conformationally rigid naproxen chiral selectors
Conformationally rigid naproxen chiral selector are designed and synthesized based on our chiral recognition hypothesis. When bonded to silica, this type of chiral selectors of rigid conformation are evaluated chromatographically and demonstrate enhanced enantioselectivity towards naproxen and …
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Synthesis and Chromatographic Evolution of Structurally Rigid Naproxen Analogs and Trans-3,4-Disubstituted-2,6-Piperidinediones
The results of a preliminary study directed towards the synthesis and chromatographic evaluation of a number of (beta-aminoalkyl)phosphonates are reported.
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Effects of chronic exposure to ibuprofen and naproxen on Florida flagfish (Jordanella floridae) over one complete life-cycle
… little selectivity while newer variants such as naproxen preferentially inhibit COX-2. Both COX isoforms share a high similarity between humans and fish creating a potential for off target effects to exposed aquatic organisms. This research investigated the chronic effects of waterborne exposure …
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The Effects of Chronic Prophylactic Naproxen Sodium on Skeletal Muscle Adaptation to Resistance Exercise in Recreationally-Trained College-Aged Males
… males were randomly assigned to placebo or naproxen sodium treatment groups. Treatments were prophylactically administered twice per week, in conjunction with a supervised periodized upper body resistance training program. Main effects for time and exercise were seen for repeated acute …
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The effects of select non-steroidal anti-inflammatory drugs on green and brown hydra
… correlations were observed between ibuprofen, naproxen, diclofenac toxicity and select endpoints in Hydra. However, these correlations generally occurred in only 25% of the 7 day exposure toxicity tests performed. Thus, environmentally relevant concentrations of ibuprofen, naproxen, and …
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Monitoring Dissolution of Nonsteroidal Anti-Inflammatory Drugs Using Infrared Spectroscopy
… to look at the formulation of three brands of naproxen sodium. These brands included Bayer Aleve ®, CVS All Day Pain Relief and Walgreens All Day Pain Relief. The active and inactive ingredients were the same yet the size and shape of the tablets differ among the three brands. S-naproxen was …
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STUDY OF CLICK CHEMISTRY: WORKING TOWARDS ‘CLICKING’ A NON-STEROIDAL ANTI-INFLAMMATORY TO AN APOPTOSIS INHIBITOR Q-VD-OPH
… a non-steroidal anti-inflammatory drug, naproxen, could possibly be coupled to an apoptosis inhibitor, Q-VD-OPh. Two synthetic routes were envisioned. The most effective click reaction was the Cu(I) catalyzed cycloaddition of naproxen propargyl ester to 4-azido-2,6-difluorophenol acetate. …
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Concomitant Suppression Of Both Cox-1 And Cox-2 Is Not Sufficient To Cause Gastroenteropathy Associated With Chronic Nsaid Use
… mice treated with the nonselective NSAID naproxen. Yet surprisingly, the COX double-knockouts never spontaneously developed any gastrointestinal damage when tracked for an entire year, whereas the naproxen mice consistently exhibit gastric and intestinal lesions and bleeding within 3 …
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Structural and chemical studies of RNA as anti-cancer target and signaling molecule
… with the protein portion of the enzyme. Naproxen was used as a scaffold to introduce functionalities which would interact with the inner surfaces of the protein portion of the enzyme. Peptide libraries using naproxen as the scaffold having varying lengths and motifs were designed. The …
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HPLC/MS mérési módszer alkalmazása települési szennyvizek, szennyvíziszapok és komposztok gyógyszermaradékainak meghatározására
… gyógyszerhatóanyagot (ibuprofen, ketoprofen, naproxen, diklofenák)
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The impact of restricted ration and chemical stressors on Rainbow trout (Oncorhynchus mykiss) and American flagfish (Jordanella floridae)
… relevant concentrations of ibuprofen, naproxen, and 17 α- ethinylestradiol (EE2) alone and in mixture on both reproduction and subsequent sensitivity to offspring. Both a short-term reproduction test, and multi-generational study were used to assess a variety of endpoints. The partial …
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Investigating human pharmaceutical compounds present in municipal and hospital wastewaters and options for their removal
… treatment plants (MWWTPs) were for paracetamol, naproxen and bezafibrate (> 1 μg/L), followed by carbamazepine, atenolol, lidocaine, sulfamethoxazole and NACS (<1 μg/L). In hospital wastewater treatment plants (HWWTPs), the highest concentrations measured were for paracetamol and caffeine (> 10 …
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Role of The Immune System In The Modulation of The Mmr-Deficient Intestinal Stem Cell Niche
… of stem cells. Our lab has also shown that naproxen, a non-steroidal anti-inflammatory drug (NSAID), has been effective at activating different subtypes of immune cells including macrophages. The purpose of this study was to understand how the immune cell compartment interacts with MMRd …
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Investigation of Non-Linear Chromatographic Retention Behavior for Two Homologous Series of Bis Analytes
… for members of the homologous series of bis naproxen amides and bis 3,5-dinitrobenzoyl amides. The maximum retention and amount of curvature for each plot is column-independent, suggesting an analyte phenomena is being observed. Maximum retention for the bis 3,5-DNB amides is found for the …
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Development and formulation of wax-based transdermal drug delivery systems
… of the solubility of ibuprofen, flurbiprofen and naproxen in the was using microscopy, Higuchi release kinetics, HyperDSC and mathematical modelling techniques. Correlations between the results obtained via these techniques were noted with additional merits such as provision of valuable …
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Methodology for the syntheses of pharmaceutically significant functional groups
… of the process route to enantiopure (S)-naproxen from batch chemistry to continuous-flow.
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Rapid separation of biologically important low molecular weight compounds by microchip electrophoresis and ultra-fast performance liquid chromatography
… for the capillary electrophoresis of (R, S) Naproxen. Variable parameters of the separation were optimized (i.e. buffer concentration and pH, concentration of chiral selector additives, applied voltage and injection condition).The method was validated in terms of linearity, precision, and …
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Preparation of amorphous forms to increase the solubility of poorly soluble drugs using spray drying
… was characterized using three model drugs-naproxen, ketoprofen and furosemide. Physical mixtures of the model drug with polyvinylpyrrolidine and spray dried composites were subjected to Fourier Transform Infrared Sprectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and Powder X-ray …
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Forecasting the Transport and Fate of Pharmaceuticals in Coarse Grained Aquifers
… carbamazepine, caffeine, gemfibrozil, ibuprofen, naproxen and sulfamethoxazole. Within the course of the project additional compounds were added to the analyses: nicotine, cotinine, ecstasy, methylated ecstasy, and cocaine. Batch sorption experiments and column tests were used to compute aquifer …
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