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Showing 1 to 15 of 15 for “"Naphthoquinones"”.
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Novel naphthoquinones and their derivatives
This dissertation deals with some novel routes investigated towards the synthesis of 1H-benz[f]indene-4,9-dione.
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The syntheses of some naturally derived naphthoquinones
The synthesis of the naphthalene core of the ansamycin antibiotics, 8-acetyl-3-acetylamino-5,7-dihydroxy-1,4-naphthoquinone from benzoquinone by means of simple reactions including, Diels-Alder adduct formation, mild acetylation, oxime formation and Beckmann rearrangement in five steps with an …
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Lewis Base Promoted Annulations of Allenoates with 1,4-Naphthoquinones
… to include amine promoted reactions of 1,4- naphthoquinones with allenoates. Several reaction conditions were attempted with promising results. Phosphine promoted reactions were also attempted with γ-substituted allenoates using 2-methyl-1,4-naphthoquinone as a coupling partner with extremely …
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SÍNTESE DE NOVOS DERIVADOS DE LAPACHONAS E NOR-LAPACHONAS: VEREDAS À ATIVIDADE FARMACOLÓGICA
In the present work the reactivity of orto-furan-naphthoquinones, para-furannaphthoquinones and para-piran-naphthoquinones was studied, in order to produce new pharmacological prototype compounds. Eighteen novel naphthoquinones were prepared. The orto-furan-naphthoquinones …
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Aspects of the chemistry of 1,4-naphthoquinones. An investigation of nucleophilic substitution reactions of alkylamines and hydroxyalyklamines on 1,4 napthoquinones and the role of solvent on the position of substitution.
… and hydroxyalkylamines with 5-substituted-1,4-naphthoquinones have been studied. It has been found that the nature of the solvent employed in the reaction influences the position of mono-substitution at either the 2- or 3-position. Although both regioisomers were produced in all the reactions, …
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Isolation and identification of Naphthoquinones from Euclea natalensis with activity against Mycobacterium tubercolosis, other pathogenic bacteria and Herpes simplex virus
… A significant synergistic effect of the two naphthoquinones was observed against M tuberculosis and some of the bacterial species. MICs obtained were 10 µg/ml and 50 µg/ml for M tuberculosis and the bacterial species respectively. No synergistic effect was observed on any Gram-negative …
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Part One: Synthetic and Degradative Studies of Two Streptovaricin Degradation Products, Streptovarone and Dapmavarone. Part Two: Synthetic and Spectral Studies of Highly Substituted 1,4-Naphthoquinones
Made available in DSpace on 2014-12-09T17:36:50Z (GMT). No. of bitstreams: 1 7021056.pdf: 6933946 bytes, checksum: 3a4cb19b63222f0503413e1b61c5cdf8 (MD5) Previous issue date: 1970
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The total synthesis of aristolindiquinone
… synthesis, of substituted C-5 oxygenated- 1,4-naphthoquinones is applied to the synthesis of (1). The critical step in the synthesis is the reaction of the novel Diels-Alder partners, dienophile (90), synthesized from 2,6-dihydroxytoluene (56), and diene (109).
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Synthesis, characterisation and application of novel quinones for the detection of latent fingermarks
… to be similar between benzoquinones, naphthoquinones and anthraquinones as they differ only by π conjugation. Another aim of this thesis was to synthesise a variety of quinones with differences in conjugation and substitution in order to compare and determine differences in quantum …
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Optimization of Quinone-Based, Extracellular Electron Transfer Mediators for Bioelectronic Applications
… was discovered. Additionally, a library of 1,4-naphthoquinones, substituted with various biogenic amines was assembled. This library was designed around probing at interactions in the L. plantarum Ndh2 active site that promotes EET. Screening for Ndh2-mediated EET in L. plantarum in the …
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Green Photochemistry: The synthesis of fine chemicals with sunlight
… prepared and converted to the corresponding 1,4-naphthoquinones, giving yields of 12-72% for artificial light irradiation (4 hours) and 23-90% for solar synthesis (6 hours). A final study looked at synthesis of juglone using alternative reaction media such as solventfree (polymer supported) …
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Biomolecular engineered sensors for diagnostic applications
… 4). The pre-treatment of the sample using naphthoquinones as labeling agents has been developed and this work was extended to examine a wholly new derivatisation agent which could have analytical and clinical/veterinary diagnostic merit. A new direction was sought to overcome the …
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Improving the Efficacy and Expanding the Application of NQO1-Bioactivated Therapeutics
NADPH:quinone oxidoreductase-1 (NQO1)-bioactivated drugs, such as ß-lapachone (ß-lap), are powerful therapeutics for tumor-specific therapy. They react with NQO1, which is highly overexpressed in most solid tumors, to cause a futile redox cycle that results in devastating oxidative DNA damage and …
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Novel Methods for Co-crystallisation
The research described in this dissertation mainly covers the development of novel technologies for co-crystallisation along with the discovering of plumbagin co-crystal and thermodynamic interrelationship between the co-crystal polymorphs. Co-crystallisation is a fast growing field in the area of …